Effect of antibodies to nerve growth factor and serum albumin on the development and behavior of mice

Klyushnik, T. P.; Krasnolobova, S A; Sarmanova, Zoya; Shcherbakova, Irina V.; Morozov, Sergey G.; Gribova, Iveta

doi:10.1007/bf02694483

Cited by 3 publications

(3 citation statements)

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“…These data indicate virtually complete loss of acquired habit in group 1 mice and its partial retention in control group. Our data on the loss of acquired habit in little mice with high level of antiMBP are in line with previous data on the effect of high level of AB to nerve growth factor on the progeny [2], which suggests, that high level of AB to various neuroantigens in the blood of animals during embryonic and early postnatal development can result in reduced training capacity.…”

Section: Groupsupporting

confidence: 93%

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Influence of high level of antibodies to myelin basic protein in female mice on the postnatal development and behavioral reactions of the progeny

et al. 2007

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Physical development, behavioral reactions, and training capacity were studied in the progeny of female BALB/c mice with high levels of antibodies to myelin basic protein. The proposed protocol of immunization ensures high levels of antibodies to myelin basic protein in this mouse strain. High level of antibodies to myelin basic protein in pregnant females causes an increase in the blood level of these antibodies in the progeny. Inhibitory effect of antibodies to myelin basic protein on physical development, training process, and memory in mouse pups was detected.

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Section: Groupsupporting

confidence: 93%

“…It was shown on experimental models that high level of antibodies (AB) to nerve growth factor in the blood of pregnant females inhibited physical development and impair learning of the progeny [2]. Increased levels of autoAB to neuroantigens, e.g.…”

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confidence: 99%

Influence of high level of antibodies to myelin basic protein in female mice on the postnatal development and behavioral reactions of the progeny

et al. 2007

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“…In studies with experimental animals, it was noted that autoantibodies binding neuroantigens in the early stages of ontogenesis contribute to the formation of various structural anomalies in the nervous system and subsequently lead to a violation of the behavior of young animals. Thus, a high level of antibodies to nerve growth factor in the blood of pregnant females has a pronounced inhibitory effect on the learning process and significantly increases the threshold of pain sensitivity in the offspring [8,56,57]. Considering the data on the penetration of immunoglobulins through the blood-brain barrier in autoimmune disorders [58,59] and the detected BBB hyperpermeability in schizophrenia [60], this phenomenon can be explained by the fact that MBP stimulates the synthesis of antibodies to myelin components.…”

Section: Proteolyticmentioning

confidence: 99%

Igg-Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia

Parshukova

Smirnova

Kornetova

et al. 2020

Journal of Immunology Research

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The level hydrolysis of myelin basic protein (MBP) by IgG in patients with schizophrenia was studied depending on the clinical features and course of the disease. The patients were grouped according to type of schizophrenia and type of disease course. We found that IgGs isolated and purified from sera of schizophrenia patients’ blood hydrolyses human MBP, and the level of this hydrolysis significantly exceeds that of healthy individuals. Detection of protease activity corresponding only to intact IgGs in polyacrylamide gel fragments, together with data of gel filtration of antibodies under conditions of “acid shock” (concordance of optical density profile of IgG with profile of MBP-hydrolyzing activity) and with the absence of any other proteins and bands in gradient SDS-PAGE and in PVDF membrane provides direct evidence that the IgGs from the schizophrenia patients have MBP-hydrolyzing activity. The antibodies-specific proteolytic activity of patients with acute schizophrenia (1.026 [0.205; 3.372] mg MBP/mg IgG/h) significantly exceeds the activity of IgG in patients in remission (0.656 [0.279; 0.873] mg MBP/mg IgG/h) and in healthy individuals (0.000 [0.00; 0.367] mg MBP/mg IgG/h). When comparing the specific activity in patients with different types of disease course, we have found that patients with a continuous course of paranoid schizophrenia (1.810 [0.746; 4.101 mg MBP/mg IgG/h]) had maximal activity values. It can be assumed that the increase in the activity of MBP-hydrolyzing antibodies is due to the activation of humoral immunity in acute schizophrenia.

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Neurodevelopment and phenotype-modulating functions of S100B protein: A pilot study

Davydov

Lobanov

Morozov

et al. 2015

Physiology & Behavior

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Effect of antibodies to nerve growth factor and serum albumin on the development and behavior of mice

Cited by 3 publications

References 1 publication

Influence of high level of antibodies to myelin basic protein in female mice on the postnatal development and behavioral reactions of the progeny

Influence of high level of antibodies to myelin basic protein in female mice on the postnatal development and behavioral reactions of the progeny

Igg-Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia

Neurodevelopment and phenotype-modulating functions of S100B protein: A pilot study

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