Effect of aqueous extract of the Vigna angularis in rats subjected to an experimental model of moderate chronic kidney disease

Baracho, Nilo César do Vale; Monteiro, Natália Fechus; Borges, Manuela Guedes; Arguelho, Raíssa Robles de Moura

doi:10.1590/s0102-865020160080000005

Cited by 12 publications

(9 citation statements)

References 15 publications

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“…It represented a decrease of 52.4% by group and 71.3% in the cancer/rat ratio. Other studies also showed better activity in lower doses in natural chemotherapy treatment, including modulation in epithelial dysplasia and, specifically, moderate dysplasia (Ribeiro and Salvadori 2007;Helli et al 2016) , (Renugadevi and Prabu 2010;Santos-Nascimento et al 2015;Baracho et al 2016) , (Mehdipour et al 2013) and other researchers observed better results in the highest dose, including epithelial acantosis and epithelial dysplasia (Mehdipour et al 2013) , (Yoshida et al 2005). In addition, reduction of squamous cell carcinoma in situ, microinvasive and invasive have also been described.…”

Section: Discussionmentioning

confidence: 89%

Negative terpinen-4-ol modulate potentially malignant and malignant lingual lesions induced by 4-nitroquinoline-1-oxide in rat model

Neto

Sorbo

Filho

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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Our aim was to verify the modulative TP-4-ol capacity in 4-nitroquinoline-1-oxide induced oral rat cancer. Methods: The stereoisomers of TP-4-ol were used against the human tongue squamous cell line and the negative stereoisomer showed lower IC50. 31 Holtzman rats (120-130 grams) were cancer induced by 4-nitroquinoline-1-oxide (4-NQO/8 weeks/25 ppm) and 32 Holtzman rats (120-130 grams) were used to Healthy and TP-4-ol toxicity experiments. Six groups were used, healthy, 0.1nL/g of TP-4-ol, 8nL/g of TP-4-ol, 4-NQO, 4-NQO+0.1nL/g of TP-4-ol and 4-NQO+8nL/g of TP-4-ol. We performed the toxicity analysis by biochemical and histopathological analysis. The biochemistry analysis includes alkaline phosphatase [ALP], alanine aminotransferase [ALT], aspartate transaminase [AST], Urea and Creatinine and the histopathology analysis includes the liver, kidney, lung, and spleen. Specifically, for malign modulation we performed a macroscopic and microscopic analysis. Results: The group exposed to 0.1nL/g of TP-4-ol demonstrated a reduced risk of malignancy in dysplasia considering the criteria of architecture and cytology. Similarly, a drop of percentual rats with SCC diagnosis was observed in 4-NQO+0.1nL/g (41.6%) when compared to 4-NQO (87.5%). Moreover, the 4-NQO group presented a median of 2.62 SCC/rat and the 4-NQO+0.1nL/g demonstrated a median of 0.75 SCC/rat. For toxicity analysis, 4-NQO+0.1nL/g showed focal necrosis in the kidney and 4-NQO showed lung hemorrhagic areas. Conclusion: The concentration of 0.1nL/g was more effective in reducing the tongue induction of potentially malignant and malignant lesions by 4-NQO. A kidney toxicity was observed in healthy animals exposed to 0.1nL/g of TP-4-ol. Clinical relevance:The negative isoform of Terpinen-4-ol negatively modulates the development of potentially malignant and malignant lesions in rats (Rattus nonverdicts albinos, Holtzman) exposed to 4-NQO. (-)-Terpinen-4-ol reduced the mice percentual with squamous cell carcinoma, 87.5% to 41.6% and decreased the cancer/rat ratio of 2.62 in 4-NQO to 0.75 in 4-NQO+0.1nL/g. This represents 52.4% by group and 71.3% in the cancer/rat ratio.

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Section: Discussionmentioning

confidence: 89%

Negative terpinen-4-ol modulate potentially malignant and malignant lingual lesions induced by 4-nitroquinoline-1-oxide in rat model

Neto

Sorbo

Filho

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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“…In addition to traditional therapy, scientists concentrate on the recent use of dietary supplements and novel natural products or their derivatives to reduce the high risk of CKD and limit the severity of this disease. In this regard, numerous studies and reviews have documented the potential impact of compounds with anti-inflammatory and antioxidant activities in CKD treatment [ 12 , 13 , 57 , 58 ]. Other studies have indicated that dietary interventions are essential in lowering inflammation and oxidative stress in CKD patients [ 57 ].…”

Section: Role Of Antioxidants In the Prevention Of Ckdmentioning

confidence: 99%

“…Some plant extracts have been investigated previously in the treatment of CKD due to their possible therapeutic properties [ 58 , 59 , 60 ]. In this regard, recent experimental studies investigated the effects of Phylanthus niruri leaves aqueous extract (PN) on renal functions, structural alteration, and biomarkers of oxidative stress, inflammation, fibrosis, apoptosis, and proliferation in the diabetes mellitus (DM) rat model.…”

Section: Role Of Antioxidants In the Prevention Of Ckdmentioning

confidence: 99%

“…An earlier study using the same model of DN demonstrated that treatment by seeds coats of Vigna angularis attenuated oxidative stress damage by reducing MDA, reduced inflammation as portrayed by decreased infiltration of macrophage, and downregulation MCP-1 gene expression [ 87 ]. The aqueous extract of Vigna angularis improved kidney function parameters in an experimental model of moderate chronic kidney disease [ 58 ].…”

Section: Role Of Antioxidants In the Prevention Of Ckdmentioning

confidence: 99%

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Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease

2021

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Chronic kidney disease (CKD) is the progressive loss of renal function and the leading cause of end-stage renal disease (ESRD). Despite optimal therapy, many patients progress to ESRD and require dialysis or transplantation. The pathogenesis of CKD involves inflammation, kidney fibrosis, and blunted renal cellular antioxidant capacity. In this review, we have focused on in vitro and in vivo experimental and clinical studies undertaken to investigate the mechanistic pathways by which these compounds exert their effects against the progression of CKD, particularly diabetic nephropathy and kidney fibrosis. The accumulated and collected data from preclinical and clinical studies revealed that these plants/bioactive compounds could activate autophagy, increase mitochondrial bioenergetics and prevent mitochondrial dysfunction, act as modulators of signaling pathways involved in inflammation, oxidative stress, and renal fibrosis. The main pathways targeted by these compounds include the canonical nuclear factor kappa B (NF-κB), canonical transforming growth factor-beta (TGF-β), autophagy, and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid factor 2-related factor 2 (Nrf2)/antioxidant response element (ARE). This review presented an updated overview of the potential benefits of these antioxidants and new strategies to treat or reduce CKD progression, although the limitations related to the traditional formulation, lack of standardization, side effects, and safety.

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“…Most of the adzuki beans cultivated in Eastern Asian countries are red in color. This legume is rich in dietary fibers, proteins, minerals, vitamin A, vitamin B9 and folate [3] . Due to its biochemical components, V. angularis has been evaluated as a new treatment option.…”

Section: Abstract: Vigna Angularis (Adzuki Bean) Total Polyphenolsmentioning

confidence: 99%

Optimization of Total Polyphenols Extraction from Vigna angularis and Their Antioxidant Activities

Zhang¹,

Wang²

2016

IJPS

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Zhang and Wang: Total Polyphenols from Vigna angularis and their EffectsVigna angularis, also called adzuki bean, a member of the family Fabaceae, has long been cultivated in Asian countries. This legume has received considerable attention owing to the presence of polyphenols. The optimal extraction conditions for total polyphenols from V. angularis and their antioxidant activities were investigated in this study. Ultrasound-assisted extraction was used to optimize the extraction of total polyphenols from V. angularis. Factors that influenced the extraction efficiency, such as ethanol concentration, liquid-solid ratio, and ultrasonic time were investigated by Box-Behnken design. Folin-Ciocalteu colorimetry was adopted to determine the total polyphenol content by using gallic acid as a reference. Antioxidant activities of the total polyphenols were evaluated by 1,1-diphenyl-2-picrylhydrazyl, hydroxyl and superoxide radical-scavenging activity assays. The optimized extraction conditions were as follows: ethanol concentration of 44.3%; liquidsolid ratio of 21.6:1 and ultrasonic extraction time of 30 min. Under these optimal conditions, the model's predicted extraction efficiency was 4.19 mg/g. The mathematical model had a high correlation (P<0.05) and could be employed to extract total polyphenols from V. angularis. In vitro antioxidant activity results showed that total polyphenols had strong antioxidant capacity and could be used as potential antioxidant agents. This study provided a reference for the exploration of new natural antioxidants. Key words: Vigna angularis (Adzuki bean), total polyphenols, extraction, Box-Behnken design, response surface methodology, antioxidant activityThe extraction of phytochemicals from food plants using solvents is an important step in separation and bioactivity research. Thus, efficient extraction techniques are required to harvest the natural products. Ultrasound-assisted extraction (UAE) is an efficient extraction technique that can help solutes more rapidly diffuse from the solid material into the solvent [1] . UAE has been widely used owing to its high efficiency, shorter processing time and reduced solvent consumption.Vigna angularis, also called adzuki beans, a member of the family Fabaceae, is an important food crop and used as folk medicines in Asian countries [2] . V. angularis have relatively small beans (about 5 mm). Most of the adzuki beans cultivated in Eastern Asian countries are red in color. This legume is rich in dietary fibers, proteins, minerals, vitamin A, vitamin B9 and folate [3] . Due to its biochemical components, V. angularis has been evaluated as a new treatment option. In addition, it has received considerable attention owing to the presence of polyphenols, such as proanthocyanidins and quercetin [4] . Numerous studies have demonstrated that polyphenols possess antioxidant [5,6] , anticarcinogenic [7,8] , antiglycation [9] and neuroprotective [10] properties. However, there are no data relating to optimized extraction conditions of total polyphenols (T...

show abstract

Effect of aqueous extract of the Vigna angularis in rats subjected to an experimental model of moderate chronic kidney disease

Cited by 12 publications

References 15 publications

Negative terpinen-4-ol modulate potentially malignant and malignant lingual lesions induced by 4-nitroquinoline-1-oxide in rat model

Negative terpinen-4-ol modulate potentially malignant and malignant lingual lesions induced by 4-nitroquinoline-1-oxide in rat model

Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease

Optimization of Total Polyphenols Extraction from Vigna angularis and Their Antioxidant Activities

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