Effect of Asbestos on Anti-Tumor Immunity and Immunological Alteration in Patients with Malignant Mesothelioma

Nishimura, Yasumasa; Maeda, Megumi; Kumagai-Τakei, Naoko; Matsuzaki, Hidenori; Lee, Sai Peck; Fukuoka, Kazuya; Nakano, Takashi; Kishimoto, Takumi; Otsuki, Takemi

doi:10.5772/33138

Cited by 6 publications

(10 citation statements)

References 45 publications

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“…As expected, MT-2 CB1 showed enhanced inhibitory function compared with that of MT-2 ORG, as well as the overproduction of IL-10 and TGF-b, which were also assumed as part of the inhibitory function [15,16,22]. These results supported our hypothesis that exposure of immune cells to asbestos causes reduction of anti-tumor immunity [1][2][3][4][5][6][7][8][9].…”

Section: Effects On Helper T Cellssupporting

confidence: 85%

“…cytotoxic lymphocytes (CTL) and natural killer (NK) cells. Since similar summaries were reported previously [1][2][3][4][5][6][7][8][9], it would be better to refer to these previous reports in addition to this review. Basically, we hypothesized that asbestos may reduce tumor immunity by affecting immune cells due to malignant complications occurring in asbestos-exposed patients such as mesothelioma and lung cancer [10][11][12][13].…”

Section: Introductionmentioning

confidence: 71%

“…T helper cells derived from asbestos-exposed patients with PP and MM revealed reduction of CXCR3 and decreased capacity for expression of IFN-c [25,26]. Since CXCR3-expressing T cells attract IFN-c-producing T cells to attack tumor cells [27,28], these effects of asbestos fibers are sufficient to reduce anti-tumor immunity in asbestos-exposed patients [1][2][3][4][5][6][7][8][9].…”

Section: Effects On Helper T Cellsmentioning

confidence: 99%

“…The overall findings show that asbestos caused reduction of NK activity as part of immunological effects of asbestos leading to the development of reduced anti-tumor immunity [1][2][3][4][5][6][7][8][9].…”

Section: Effects On Nk Cellsmentioning

confidence: 99%

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Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment

Otsuki

Matsuzaki

Lee

et al. 2015

Environ Health Prev Med

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Among the various scientific fields covered in the area of hygiene such as environmental medicine, epidemiology, public health and preventive medicine, we are investigating the immunological effects of fibrous and particulate substances in the environment and work surroundings, such as asbestos fibers and silica particles. In addition to these studies, we have attempted to construct health-promoting living conditions. Thus, in this review we will summarize our investigations regarding the (1) immunological effects of asbestos fibers, (2) immunological effects of silica particles, and (

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Section: Effects On Helper T Cellssupporting

confidence: 85%

Section: Introductionmentioning

confidence: 71%

Section: Effects On Helper T Cellsmentioning

confidence: 99%

Section: Effects On Nk Cellsmentioning

confidence: 99%

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Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment

Otsuki

Matsuzaki

Lee

et al. 2015

Environ Health Prev Med

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“…The killing activity and expression of activating receptors in NK cells freshly isolated from asbestos-exposed patients such as PP and MM were then compared with those of healthy donors. As shown in figure 3, the expression of one NK cell activating receptor, NKp46, was decreased and positively related with killing activity [62,63].…”

Section: Change Of Nkp46 Expression For Nk Cells In Asbestos-exposed mentioning

confidence: 99%

Exploration of Biomarkers for Asbestos Exposure and Occurrence of Malignant Mesothelioma Based on the Immunological Effects of Asbestos

Matsuzaki¹,

Lee²,

Takei-Kumagai³

et al. 2013

J Data Mining in Genom Proteomics

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Investigation was carried out on the immunological effects of asbestos on individuals and found that asbestos exposure not only reduces the effectiveness of tumor surveillance but also makes asbestos exposed individuals sensitive to tumor development. The continuous experimental exposure of T cells to asbestos has enhanced production of IL-10 and TGF-β. It has also provoked over expression of Bcl-2 with reduced expression of cell-surface CXCR3 and suppressed IFN-γ production with decreased expression of activating receptors such as NKp46 in NK cells. These alterations were also detected in asbestos-exposed patients such as those with pleural plaque or mesothelioma. Such changes in combination with certain markers produced by mesothelioma cells may therefore be considered as an initial screening system for asbestos exposure and developing mesothelioma using peripheral blood.

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Suppressive Effects of Asbestos Exposure on the Human Immune Surveillance System

Nishimura

Kumagai-Τakei

Maeda

et al. 2016

Current Topics in Environmental Health and Preventive Medicine

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Effect of Asbestos on Anti-Tumor Immunity and Immunological Alteration in Patients with Malignant Mesothelioma

Cited by 6 publications

References 45 publications

Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment

Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment

Exploration of Biomarkers for Asbestos Exposure and Occurrence of Malignant Mesothelioma Based on the Immunological Effects of Asbestos

Suppressive Effects of Asbestos Exposure on the Human Immune Surveillance System

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