Effect of beta-adrenergic blockade on circulating catecholamines and dopamine-beta-hydroxylase activity during exercise in normal subjects

Sheehan, M W; Brammell, H. L.; Sable, D. L.; Nies, Alan S.; Horwitz, Lawrence D.

doi:10.1016/0002-8703(83)90240-5

Cited by 22 publications

(7 citation statements)

References 16 publications

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“…As shown here, the handgrip-induced elevation in NE was not affected by treatment, while the E level was increased. During treadmill exercise, the marked increase in NE was not affected by propranolol [37], whereas here both atenolol and bopindolol appeared to reduce the change. Propranolol and atenolol did not affect the treadmill-induced change in E, but bopindolol increased it.…”

Section: Discussioncontrasting

confidence: 51%

“…They found that the response of NE was increased by propranolol, but not by metoprolol, and that plasma E was decreased by metoprolol. Sheeham et al [37] desenbed the effects of propranolol on catecholamine levels during handgrip and treadmill exercises. As shown here, the handgrip-induced elevation in NE was not affected by treatment, while the E level was increased.…”

Section: Discussionmentioning

confidence: 99%

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Effects of mental and physical stress on plasma catecholamine levels before and afterβ-adrenoceptor blocker treatment

Paran

Neumann

Cristal

1992

Eur J Clin Pharmacol

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In a study in mild hypertensives, the impact of mental and physical stress on plasma epinephrine (E), norepinephrine (NE), and on their ratio (NE/E) was evaluated. The effect of two beta-adrenoceptor blocking drugs, atenolol and bopindolol, on plasma catecholamine levels was also examined. Each stressful stimulus significantly increased the NE and E levels compared to rest. The increase was progressive from mental stress, through the handgrip test to the treadmill test. A slight decrease in the NE/E ratio was observed following mental stress and the handgrip test, while this ratio increased during the treadmill test. No significant impact of beta blocking treatment on catecholamine levels was observed under any test condition.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Effects of mental and physical stress on plasma catecholamine levels before and afterβ-adrenoceptor blocker treatment

Paran

Neumann

Cristal

1992

Eur J Clin Pharmacol

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“…Therefore, the administration of propranolol has no effect on NE levels and only a small effect on EN levels during submaximal exercise [22]. Higher EN levels, but not NE levels, were also found after arotinolol treatment.…”

Section: Discussionmentioning

confidence: 85%

Effects of arotinolol on exercise capacity and humoral factors during exercise in normal subjects

Mori

Handa

Terao

et al. 1992

Cardiovasc Drug Ther

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A placebo-controlled, double-blind crossover study was undertaken in 10 normal subjects to examine the effects of arotinolol (10 mg bid), a nonselective beta blocker with alpha-blocking activity, on exercise capacity and hormone levels during exercise after a 2-week treatment period. Maximal oxygen uptake (VO2 max) and blood lactic acid concentration (LA) were measured during progressive exercise testing. An exercise intensity equivalent to 4 mmol/l of LA was used for the constant workload exercise test. Humoral factors were measured after 20 minutes of constant workload exercise. The administration of arotinolol significantly decreased systolic blood pressure and heart rate at rest and during exercise, but diastolic blood pressure did not change. No significant difference was found between arotinolol and placebo with regard to VO2 max and maximal workload. Plasma renin activity (PRA), aldosterone (PAC), and norepinephrine (NE) levels at rest and during exercise did not differ between the two treatments. In contrast, plasma epinephrine (EN) levels at rest and during exercise were significantly greater with arotinolol. Atrial natriuretic peptide (ANP) at rest did not differ between the two treatments. However, exercise caused a significant increase in ANP after arotinolol treatment. These findings suggest that arotinolol decreases blood pressure and heart rate without affecting exercise capacity.

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“…Several investigators found significant reductions in peak oxygen consumption during maximal exercise (2,4,18,28,29,43,53). Others have reported minimal or no decrease in 16 oxygen consumption at maximal exercise (40,61,62,77,78), and it has been noted that BB increases exercise capacity in symptomatic populations, i.e., angina patients (11).…”

mentioning

confidence: 99%

“…Many investigations have found BB to decrease exercise endurance time and/or work capacity (2,18,21,22,35,61,78). The duration of work was 3 to 4 times longer with the latter protocol in both drug and non-drug trials.…”

mentioning

confidence: 99%

Exercise Response to Acute and Chronic Beta Blockade in Healthy Male Subjects

Jilka

Joyner

Wilmore

1986

Medicine & Science in Sports & Exercise

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Effect of beta-adrenergic blockade on circulating catecholamines and dopamine-beta-hydroxylase activity during exercise in normal subjects

Cited by 22 publications

References 16 publications

Effects of mental and physical stress on plasma catecholamine levels before and afterβ-adrenoceptor blocker treatment

Effects of mental and physical stress on plasma catecholamine levels before and afterβ-adrenoceptor blocker treatment

Effects of arotinolol on exercise capacity and humoral factors during exercise in normal subjects

Exercise Response to Acute and Chronic Beta Blockade in Healthy Male Subjects

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