Effect of biogenic silver nanocubes on matrix metalloproteinases 2 and 9 expressions in hyperglycemic skin injury and its impact in early wound healing in streptozotocin-induced diabetic mice

Krishnan, Natarajan; Velramar, Balasubramanian; Ramatchandirin, Balamurugan; Abraham, G C; Duraisamy, Nivas; Pandiyan, Rajesh; Velu, Rajesh Kannan

doi:10.1016/j.msec.2018.05.020

Cited by 38 publications

(18 citation statements)

References 28 publications

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“…They further investigated the effect of biogenic Ag nanocubes on MMP‐2 and MMP‐9 expression as their high expression impairs the wound healing process via the degradation of ECM of skin [81]. It was found that AgNPs synthesized biologically from B. brevis KN8(2) downregulated the MMP‐2 and MMP‐9 expression and promoted wound healing in the diabetic model [82].…”

Section: Resultsmentioning

confidence: 99%

Nanotechnology‐driven advances in the treatment of diabetic wounds

Zare

Rezayi

Aryan

et al. 2020

Biotechnology and Applied Biochemistry

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Diabetic foot ulcers (DFUs) are chronic severe complications of diabetes disease and remain a worldwide clinical challenge with social and economic consequences. Diabetic wounds can cause infection, amputation of lower extremities, and even death. Several factors including impaired angiogenesis, vascular insufficiency, and bacterial infections result in a delayed process of wound healing in diabetic patients. Treatment of wound infections using traditional antibiotics has become a critical status. Thus, finding new therapeutic strategies to manage diabetic wounds is urgently needed. Nanotechnology has emerged as an efficient approach for this purpose. This review aimed to summarize recent advances using nanotechnology for the treatment of diabetic wounds.

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Section: Resultsmentioning

confidence: 99%

Nanotechnology‐driven advances in the treatment of diabetic wounds

Zare

Rezayi

Aryan

et al. 2020

Biotechnology and Applied Biochemistry

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“…AgNPs were more powerful in decreasing the expression of MMP2 and MMP9 genes compared to the commercial drug. Various in vitro reports indicated that AgNPs decreased the mRNA and protein expression of MMP-2 and MMP-9 in wounded granulation tissues (Krishnan et al 2018 ). Numerous studies have reported that treating MCF-7 cancer cells with AgNPs could lead to apoptosis by inducing the release of cytochrome c, production of reactive oxygen species (Iniyan et al), and activation of the caspase-3 pathway (Al-Nuairi et al 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

Noorbazargan¹,

amintehrani²,

Dolatabadi³

et al. 2021

AMB Expr

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The current study evaluated the anti-cancer properties of bio-functionalized silver nanoparticles fabricated by Juniperus chinensis leaf extracts. The nanoparticles were characterized by scanning electron microscopy, transmission electron microscopy, UV–visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, dynamic light scattering, Zeta potential and X-ray spectroscopy. Further, this study elucidated the cellular and molecular mechanisms of nanoparticles for anti-proliferative and apoptotic effects on human lung cancer cells (A549) and compared them with commercial drug cisplatin. The size of the spherical nanoparticle was 12.96 nm with negative zeta potential. Up-regulation of caspase 3,9 and p53, Annexin V-FITC/PI, DAPI staining, and ROS production indicated the remarkable apoptotic effect of AgNPs compared to cisplatin. Moreover, down-regulation of MMP2/MMP9 scratch and matrigel assays revealed anti-metastatic properties of AgNPs. Cell cycle analysis and downregulation of cyclin D1 indicated cancer cell cessation in the G0/G1 phase. Overall, the results revealed that the green-synthetized AgNPs had anti-metastasis and anti-proliferation effects on lung cancer cells in comparison to cisplatin with lower side effects on the normal cell line.

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“…Silver nanoparticles most especially have been fabricated from natural sources and studied extensively [7e12]. Silver has long been used to prevent and kill chronic wound infection due to their anti-inflammatory and antimicrobial abilities [13].…”

Section: Introductionmentioning

confidence: 99%