Effect of Bisphenol A on the lung of adult male albino rats and the possible protective role of propolis: Light and electron microscopic study

Soliman, Mahmoud E.; Noya, Dalia A.

doi:10.21608/ejh.2021.83475.1515

Cited by 2 publications

(2 citation statements)

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“…Similarly to phthalates, bisphenol A is associated with asthma [93,97,[104][105][106]. Bisphenols also cause collapsed alveoli and morphological changes in the mucosa, blood vessels, and interalveolar septum [107,108], as well as lung development disorders [109,110]. These two examples of additives exhibiting lung toxicity are concerning considering the numerous other chemicals that may also leak into the lungs following MP inhalation exposure.…”

Section: Toxicity Of Additivesmentioning

confidence: 99%

Inhalation of Microplastics—A Toxicological Complexity

Borgatta,

Breider

2024

Toxics

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Humans are chronically exposed to airborne microplastics (MPs) by inhalation. Various types of polymer particles have been detected in lung samples, which could pose a threat to human health. Inhalation toxicological studies are crucial for assessing the effects of airborne MPs and for exposure-reduction measures. This communication paper addresses important health concerns related to MPs, taking into consideration three levels of complexity, i.e., the particles themselves, the additives present in the plastics, and the exogenous substances adsorbed onto them. This approach aims to obtain a comprehensive toxicological profile of deposited MPs in the lungs, encompassing local and systemic effects. The physicochemical characteristics of MPs may play a pivotal role in lung toxicity. Although evidence suggests toxic effects of MPs in animal and cell models, no established causal link with pulmonary or systemic diseases in humans has been established. The transfer of MPs and associated chemicals from the lungs into the bloodstream and/or pulmonary circulation remains to be confirmed in humans. Understanding the toxicity of MPs requires a multidisciplinary investigation using a One Health approach.

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Section: Toxicity Of Additivesmentioning

confidence: 99%

Inhalation of Microplastics—A Toxicological Complexity

Borgatta,

Breider

2024

Toxics

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“…In addition, feed intake and growth that were retarded by BPA have been significantly improved by propolis supplementation. Another study also found that co-supplementation of propolis minimizes BPA-induced structural changes in rat lungs [ 216 ]. These reports indicated that propolis can be used as a protective agent against BPA toxicity.…”

Section: Various Natural Products That Are Effective Against Bpa-indu...mentioning

confidence: 99%

Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use

et al. 2022

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Bisphenol A (BPA) is a ubiquitous environmental toxin with deleterious endocrine-disrupting effects. It is widely used in producing epoxy resins, polycarbonate plastics, and polyvinyl chloride plastics. Human beings are regularly exposed to BPA through inhalation, ingestion, and topical absorption routes. The prevalence of BPA exposure has considerably increased over the past decades. Previous research studies have found a plethora of evidence of BPA’s harmful effects. Interestingly, even at a lower concentration, this industrial product was found to be harmful at cellular and tissue levels, affecting various body functions. A noble and possible treatment could be made plausible by using natural products (NPs). In this review, we highlight existing experimental evidence of NPs against BPA exposure-induced adverse effects, which involve the body’s reproductive, neurological, hepatic, renal, cardiovascular, and endocrine systems. The review also focuses on the targeted signaling pathways of NPs involved in BPA-induced toxicity. Although potential molecular mechanisms underlying BPA-induced toxicity have been investigated, there is currently no specific targeted treatment for BPA-induced toxicity. Hence, natural products could be considered for future therapeutic use against adverse and harmful effects of BPA exposure.

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Effect of Bisphenol A on the lung of adult male albino rats and the possible protective role of propolis: Light and electron microscopic study

Cited by 2 publications

References 0 publications

Inhalation of Microplastics—A Toxicological Complexity

Inhalation of Microplastics—A Toxicological Complexity

Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use

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