Effect of boron incorporation on the bioactivity, structure, and mechanical properties of ordered mesoporous bioactive glasses

Deilmann, Leonie; Winter, Oliver; Cerrutti, Bianca M.; Bradtmüller, Henrik; Herzig, Christopher; Limbeck, Andreas; Lahayne, Olaf; Hellmich, Christian; Eckert, Hellmut; Eder, Dominik

doi:10.1039/c9tb01805k

Cited by 38 publications

(19 citation statements)

References 33 publications

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“…In this study, a B-BG was obtained from boron which completely replaced sodium. Studies from previous articles have confirmed its osteoinductive aptitude and degradation characteristics (Xia et al, 2019;Deilmann et al, 2020;Houaoui et al, 2020;Li et al, 2020). Also, implants that were hard to degrade were described to cause long-term inflammatory reactions, and stress shielding occurs, which results in bone resorption and implant loosening due to mechanical properties that do not match that of the natural bone (Fedorowicz et al, 2007;Xu et al, 2020).…”

Section: Introductionmentioning

confidence: 98%

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Zhang

Yang

Zhou

et al. 2020

Front. Bioeng. Biotechnol.

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Graft reconstruction of the mandible is an important approach that aims at improving the appearance and functionality of defected mandibles. The traditional implant materials are generally bioinert, non-degradable, and that they lack favorable pore structures for cell proliferation, which limit their clinical application. In this study, we used boron-containing bioactive glass which was combined with a three-dimensional (3D) printing technology to construct an osteoinductive implant scaffold, according to the imaging instructions of CT scan on bone defects. Here, the boron-containing bioglass scaffold (B-BGs) was prepared through sol-gel processing and a 3D print technique. Different boron content of borosilicate bioglass was prepared by incorporating B2O3 (molar: 19.4 and 38.8%) into 58S bioglass to replace parts of SiO2. For fabricated mandible implants through three-dimensional 3D printing of B-BGs (size: 8 × 2 mm; pore size: 250 μm) modified with borosilicate bioglass powder and sodium alginate. Notably, the compressive strength of the B-BGs was about 3.8 Mpa, which supported mandibular activity. Subsequently, the excellent biocompatibility of B-BGs was confirmed using cytotoxicity in vitro studies. Finally, data from in vivo experiments demonstrated that the B-BGs could promote bone regeneration and they could almost get completely degraded within 4 weeks. Our results showed that the boron-containing bioglass could repair mandibular defects.

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Section: Introductionmentioning

confidence: 98%

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Zhang

Yang

Zhou

et al. 2020

Front. Bioeng. Biotechnol.

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“…Both Si and P are considered to be network formers in the inorganic structures; however, 29 Si and 31 P NMR studies of the sol-gel bioactive glasses have shown that phosphorous predominately appears as orthophosphate ions, charge-balanced with cations such as Ca 2+ and Na + [ 24 , 25 ]. In the absence of sufficient network modifier cations or the presence of other anions competing for charge compensation such as boron [ 26 ], and in compositions with high P content, phosphorus appears as pyrophosphate and Si–O–P [ 27 ], and might form phosphorus-rich regions of 1.5–2 nm in size [ 25 ]. Given the fact that the network modifiers cations are consumed for charge-balancing with orthophosphate ions instead of the non-bridging oxygens, the silica network connectivity increases, and subsequently, the mechanical strength of the glass increases.…”

Section: Resultsmentioning

confidence: 99%

Bioactive fluorescent hybrid microparticles as a stand-alone osteogenic differentiation inducer

Aslankoohi

Lin

Mequanint

2022

Materials Today Bio

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Osteogenic differentiation of stem cells is one of the essential steps in bone regeneration. While supplementing exogenous factors using differentiation media is the established method to differentiate stem cells into osteoblasts on biomaterials, designing biomaterials that can act as a stand-alone differentiation inducer and promote bone regeneration is preferred for clinical translation. In this work, we report dexamethasone-loaded organic-inorganic hybrid microparticles synthesized from an intrinsically fluorescent poly (ester amide) and tertiary bioactive glass (PEA-BG) as a stand-alone osteogenic differentiation inducer. The mechanical properties data indicated that the compressive modulus of fluorescent hybrid microparticles could be modulated by its composition. The hybrid fluorescent microparticles supported the adhesion and proliferation of 10T1/2 cells in culture for up to seven days. Both pristine and dexamethasone-loaded PEA-BG microparticles were able to induce osteogenic differentiation of 10T1/2 cells in the absence of any media supplement, to a level even higher than standard osteogenic media, as evidenced by the expression of osteogenic markers on gene and protein levels and matrix mineralization. Taken together, the fluorescent PEA-BG hybrid microparticles have the potential to be used as a stand-alone biomaterial for osteogenic differentiation and bone regeneration.

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“…Lastly, the development of MBGs incorporating other network formers than silica could further improve the versatility and therapeutic potential of these materials. To the best of the authors' knowledge, only one study was reported on the synthesis of borosilicate MBGs [103], which could have appealing implications in the context of wound healing and soft tissue engineering similar to their melt-derived counterparts (e.g., 13-93B3 glass [104]).…”

Section: Discussionmentioning

confidence: 99%

A Guided Walk through the World of Mesoporous Bioactive Glasses (MBGs): Fundamentals, Processing, and Applications

et al. 2020

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Bioactive glasses (BGs) are traditionally known to be able to bond to living bone and stimulate bone regeneration. The production of such materials in a mesoporous form allowed scientists to dramatically expand the versatility of oxide-based glass systems as well as their applications in biomedicine. These nanostructured materials, called mesoporous bioactive glasses (MBGs), not only exhibit an ultrafast mineralization rate but can be used as vehicles for the sustained delivery of drugs, which are hosted inside the mesopores, and therapeutic ions, which are released during material dissolution in contact with biological fluids. This review paper summarizes the main strategies for the preparation of MBGs, as well as their properties and applications in the biomedical field, with an emphasis on the methodological aspects and the promise of hierarchical systems with multiscale porosity.

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Effect of boron incorporation on the bioactivity, structure, and mechanical properties of ordered mesoporous bioactive glasses

Abstract: B2O3 doped (0.5–15 mol%) ordered mesoporous bioactive glasses were synthesized via sol–gel based evaporation-induced self-assembly using P123 as a structure directing agent and characterized by biokinetic, mechanical and structural investigations.

Cited by 38 publications

References 33 publications

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Bioactive fluorescent hybrid microparticles as a stand-alone osteogenic differentiation inducer

A Guided Walk through the World of Mesoporous Bioactive Glasses (MBGs): Fundamentals, Processing, and Applications

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