Effect of Brassica oleracea in rats skin wound healing

Abstract

PURPOSE:To investigate the effect of Brassica oleracea herbal balsam on the healing of skin wounds in rats. METHODS:Twenty four rats (Wistar, 60 days, 250 g) were divided into four groups: untreated animals (C) and treated with the ointment (T), subdivided into two experimental times (seven and 16 days). A 3cm 2 skin wound was made in the back of all animals.100 ml of the Brassica oleracea was applied twice a day in T group. Biometric analysis was made with images captured at one, four, seven, ten, 13, and 16 days. At seven and 16 days, animals of each group were euthanized. The wound area removed was processed for histological and histomorphometric analysis to quantify birefringent collagen fibers. Statistical analysis was made considering p < 0.05 as significant. RESULTS:Biometric analysis revealed no significant differences between groups in both experimental times studied. However, histomorphometric analysis showed that the number of type I collagen fibers was significantly higher in the specimens of the group T16 compared to the other groups. CONCLUSION:Brassica oleracea accelerated the wound healing process increasing the number of type I collagen fibers and the maturity of the newly formed tissue.

Comparison of experimentally-induced wounds in rabbits treated with different sources of platelet-rich plasma

“…Wound healing is a complex biological process involving cellular and chemical responses, with the initial purpose of reorganizing the extracellular matrix components with the objective of rapid wound closure, in addition to the obtaining of a functional and aesthetically satisfactory scar. 1,2 Although there is no epidemiological data on this in Brazil, alterations in skin integrity affect the quality of life of sufferers and constitute a serious public health problem as they have physical, psychological and social impacts, coupled with high economic costs. 3 Studies of platelet-rich plasma (PRP) focus on the evaluation of their growth factors, which are important in the repair of wounds during healing and are released through platelet degranulation.…”

Treatment of A Traumatic Injury of Hand With Persian Medicine

“…In the conventional medicine articles, there is some evidences of positive effect of these plants on the wounds. A study in Brazil in 2013 found that an ointment made from the cabbage extract, accelerated wound healing by mechanism of increasing collagen type 1 fibers [15]. In the case of marshmallow, its effects on increasing the gene expression associated with specific cell adhesion proteins, growth regulators, extracellular matrix, cytokine release and apoptosis have been proven.…”

Ointment ofBrassica oleraceavar.capitataMatures the Extracellular Matrix in Skin Wounds of Wistar Rats

“…However, the synthesis of this component of the matrix was connected to good tissue vascularization that provided oxygen and nutrients to the tissue for optimal metabolic activity of the fibroblasts and was more abundant and important for cell synthesis of the matrix components [ 2 , 37 , 38 ]. In addition to flavonoids, the compounds and phytochemicals in the B. oleracea extract included phenols, sulforanos, and anthocyanins [ 27 , 28 , 39 ], which had a positive effect on collagen type I expression and gradually influenced a reduction in the expression of collagen type III [ 28 ].…”