Effect of Calcium Phosphate Cements on Growth and Odontoblastic Differentiation in Human Dental Pulp Cells

Lee, Sun-Kyung; Lee, Sang-Kwang; Lee, Sang‐im; Park, Jeong-Hui; Jang, Jun‐Hyeog; Kim, Hae‐Won; Kim, Eun-Cheol

doi:10.1016/j.joen.2010.04.027

Cited by 60 publications

(45 citation statements)

References 27 publications

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“…This could be due to the fact that NCP promotes Human differentiated pulp cells (HDPC) differentiation (25) . Moreover, β-TCP act as an excellent substrate on which odontoblast-like cells can attach themselves to produce a hard tissue, thus preserving normal histological pulp patterns and pulp vitality (21) .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Incorporating Nanocalcium Phosphate Particles into Biodentine on Pulpal Tissue Response (In Vitro Study)

Aidaros

Niazy²,

El-yassaky

2018

ADJ-for Girls

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Objectives: This study was conducted to evaluate the effect of incorporating Nanocalcium phosphate (NCP) particles into Biodentine™ on pulpal tissue response as a direct pulp capping material (entire tooth culture model). Materials and methods: -A total of forty freshly human premolar teeth extracted for orthodontic reasons were used. After cavity preparation and mechanical pulp exposure, the teeth were divided into 2 main groups (20 teeth each) according to the capping material used; where group (M1) refers to pulps capped with Biodentine™, and group (M2) refers to pulps capped with Biodentine incorporated with NCP. Each group was further subdivided into two subgroups according to the culture period; where subgroup (P1) refers to teeth cultured for 14 days, and subgroup (P2) refers to teeth cultured for 28 days. At the end of each culture period, the teeth were histologically examined to assess the dentine bridge thickness of each group after 14 and 28 days. Moreover, elemental analysis of Calcium and Phosphorous ions in the dentine bridge was performed using SEM-EDX. Results: Direct pulp capping with Biodentine incorporated with NCP showed thicker dentine bridge when compared to Biodentine™ alone. There is a positive correlation between the weight % of Calcium and Phosphorous ions in the dentine bridge below both capping materials and the dentine bridge thickness. Conclusion: Biodentine incorporated with NCP could be a good candidate for pulp capping in the future.

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Section: Discussionmentioning

confidence: 99%

The Effect of Incorporating Nanocalcium Phosphate Particles into Biodentine on Pulpal Tissue Response (In Vitro Study)

Aidaros

Niazy²,

El-yassaky

2018

ADJ-for Girls

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“…However, the cement acted as a scaffold for bone formation and provided histocompatible healing of periodontal tissues [486]. Still other investigators used a cement for direct pulp capping [487,488] and compared it to calcium hydroxide. Both materials were found to be equally capable of producing a secondary dentin at ~ 24 weeks [488].…”

Section: Dental Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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“…KarıĢtırıldığında öncelikli olarak hidroksiapatiti oluĢtururlar. 34,35 Kalsiyum hidroksitten daha yüksek fiziksel özelliklere sahiptir. Yük gelen alanlarda bile sıkıĢma dayanımının orta düzeydedir.…”

Section: Iģıkla Sertleģen Trikalsiyum Silikat Simanunclassified

“…Bu sebepten pulpa kaplamalarında ya da bir materyal altında liner olarak kullanılabilir. 34,36 Trikalsiyum fosfat siman, düĢük reaktivite gös-teren ve çözünebilen biyoseramik bir materyaldir. Kalsiyum salabilmesi ve biyouyumluluğu sayesinde odontoblastları uyarır ve böylece dentin köprüsü yapımını sağlar.…”

Section: Iģıkla Sertleģen Trikalsiyum Silikat Simanunclassified

Restorati̇f Di̇ş Tedavi̇si̇nde Pulpa Kaplamalari

Oğlakçı¹,

Arhun²,

Tuncer³

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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ÖZTravmaya uğramıĢ veya derin çürük lezyonlarına sahip diĢlere, pulpa vitalitesinin devam etmesi için vital pulpa tedavileri uygulanmaktadır. Günümüzde en çok uygulanan vital pulpa tedavisi prosedürü, pulpa kaplamasıdır. Remineralize olabilen dekalsifiye dentin dokusunun veya ekspoz olmuĢ pulpanın biyouyumlu bir materyalle örtülmesi ve tersiyer dentin yapımının uyarılması amaçlanır. Ġki tip pulpa kaplaması yöntemi vardır: Ġndirekt pulpa kaplaması ve direkt pulpa kaplaması. Ġndirekt pulpa kaplamalarında en çok kendi kendine sertleĢebilen kalsiyum hidroksit içerikli patlar ve çinko oksit öjenol simanlar kullanılmaktadır. Ayrıca, adeziv sistemler gibi alternatif pulpa kaplaması materyallerinin kullanımı da gündeme gelmiĢtir. Toz kalsiyum hidroksit, direkt pulpa kaplamalarında geleneksel olarak kullanılan en güvenilir materyal iken günümüzde mineral trioksit agregat altın standart olarak kabul edilir. Bu derlemenin amacı, pulpanın canlılığını korumak için açık pulpa üzerine veya pulpaya çok yaklaĢıldığında dentine yerleĢtirilen, yeni nesil biyouyumlu taban materyallerini (liner ve(ya) base) değerlendirmektir. Anahtar kelimeler: pulpa kaplaması, kalsiyum hidroksit, adeziv, mineral trioksit agregat, trikalsiyum silikat siman. PULPA KAPLAMALARITravmaya uğramıĢ (malokluzyon, atrizyon, abrazyon, erozyon, mekanik travma) veya derin çürük lezyonlarına sahip diĢlere, pulpa vitalitesinin devam etmesi için vital pulpa tedavisi uygulanmaktadır. En çok uygulanan vital pulpa tedavisi prosedürü pulpa kaplamasıdır. Koronal pulpanın uzaklaĢtırılması ise ABSTRACTThe vital pulp treatments are applied to the teeth with deep caries lesion or trauma for the purpose of maintaining the vitality of pulp. Nowadays, the most commonly performed treatment procedure is vital pulp capping. It is intended that the decalcified dentine which can be remineralized or exposed pulp are sealed with a biocompatible material and promotion of tertiary dentin formation. There are two types of pulp capping procedure: direct and indirect pulp capping. Traditionally, self-curing calcium hydroxide paste and zinc oxide-eugenol are carried out in indirect pulp capping. Furthermore, the use of alternative pulp capping materials such as adhesive systems has also been on the agenda. Even as, powdered calcium hydroxide conventionally used in direct pulp capping is the most reliable material; at the present time mineral trioxide aggregate is considered as the gold standard. Aim of this review is to evaluate new generation biocompatible base materials (liner and/or base) that used on exposed pulp or remained small amount of dentine over the pulp in order to maintain the vitality of the pulp. Keywords: pulp capping, calcium hydroxide, adhesive, mineral trioxide aggregate, tricalcium silicate cement.günümüzde pek tercih edilen bir tedavi seçeneği değildir.1,2 Çürüğün tamamen uzaklaĢtırılması sırasında çürük içermeyen, iĢleme bağlı (iatrojenik) veya travmatik yaralanmalarla, pulpanın açığa çıkma riski olan asemptomatik diĢlerde, remineralize olabilen dekalsifiye dentin do...

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Effect of Calcium Phosphate Cements on Growth and Odontoblastic Differentiation in Human Dental Pulp Cells

Cited by 60 publications

References 27 publications

The Effect of Incorporating Nanocalcium Phosphate Particles into Biodentine on Pulpal Tissue Response (In Vitro Study)

The Effect of Incorporating Nanocalcium Phosphate Particles into Biodentine on Pulpal Tissue Response (In Vitro Study)

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Restorati̇f Di̇ş Tedavi̇si̇nde Pulpa Kaplamalari

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