Effect of carbamazepine and valproate on bone mineral density

Effects of antiepileptic drugs on bone mineral density and bone metabolism in children: A meta-analysis

“…The initial search yielded 1603 research reports, of which 228 were excluded due to identical title or authors; 1056 were excluded due to ineligible study design (including non-human studies, review articles, case reports, comment, letter, experimental study, and/or fractureonly outcome). After full-text screening, 22 studies were included (Chung and Ahn, 1994;Baer et al, 1997;Akin et al, 1998;Kafali et al, 1999;Erbayat Altay et al, 2000;Verrotti et al, 2002;Voudris et al, 2002;Ecevit et al, 2004;Oner et al, 2004;Babayigit et al, 2006;Kumandas et al, 2006;Nicolaidou et al, 2006;El-Hajj Fuleihan et al, 2008;Nettekoven et al, 2008;Gniatkowska-Nowakowska, 2010;Rauchenzauner et al, 2010;Babacan et al, 2012;Dimić et al, 2013;Razazizan et al, 2013;Turan et al, 2014). Table 1 summarizes the characteristics of the included studies published between 1994 and 2014.…”

Metabolic consequences of antiepileptic drugs

“…Yet not all of the available evidence is consistent with this hypothesis. Studies of patients taking CBZ have yielded mixed results regarding its effects on bone density (4,15,16). In addition, the enzyme-inhibiting drug valproate (VPA) has been implicated as a potential cause of reduced bone density (15,16) and fracture risk (13,14).…”

The effect of anticonvulsant use on bone mineral density in non-ambulatory children with cerebral palsy

“…There was no control group and the findings were only compared with paediatric data from the manufacturer, rendering it difficult to detect any small but significant difference secondary to AED treatment. Ecevit et al 23 measured femoral neck BMD in 31 healthy children and 33 subjects with idiopathic epilepsy treated with either carbamazepine (n=17) or valproate (n=16). Valproate but not carbamazepine monotherapy was associated with a significant reduction in BMD.…”