Effect of Chlorella Pyrenoidosa Protein Hydrolysate-Calcium Chelate on Calcium Absorption Metabolism and Gut Microbiota Composition in Low-Calcium Diet-Fed Rats

Hua, Pengpeng; Xiong, Yu; Yu, Zhiying; Liu, Bin; Zhao, Liang

doi:10.3390/md17060348

Cited by 33 publications

(22 citation statements)

References 90 publications

(118 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, it was found that human gut bacteria can synthesize proteinogenic amino acids and produce a range of metabolites via protein fermentation, some known to exert beneficial or harmful physiological effects on the host [77][78][79][80][81][82][83]. It is still in an early stage whether the type and amount of dietary protein consumed affect the diversity and composition of the intestinal microbiota, and the luminal environment of the intestinal epithelium and peripheral tissues on the host health.…”

Section: Discussionmentioning

confidence: 99%

Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones

et al. 2020

View full text Add to dashboard Cite

In recent years, growth hormone deficiency in children has been treated with hormone therapy despite the possible significant side effects. Therefore, it was deemed beneficial to develop functional foods or dietary supplements for safely improving children’s growth. Spirulina platensis is known for its high antioxidant, anti-aging, anti-cancer, and immunity-enhancing properties, as well as its high digestibility and high protein content, but little has been reported about its influence on bone development in children with a normal supply of protein. In this study, we evaluated the effects of spirulina on the bone metabolism and antioxidant profiles of three-week-old growing male rats. The animals were divided into four groups (n = 17 per group) and were fed AIN93G diets with 0% (control), 30% (SP30), 50% (SP50), and 70% (SP70) of casein protein replaced by spirulina, respectively, for seven weeks. We observed that spirulina enhanced bone growth and bone strength by stimulating parathyroid hormone and growth hormone activities, as well its increased antioxidant activity. These results indicate that spirulina provides a suitable dietary supplement and alternative protein source with antioxidant benefits for growth improvement in early developmental stages.

show abstract

Section: Discussionmentioning

confidence: 99%

Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Informed written consent was obtained from 100 volunteers. e present study was conducted as a randomized control trial using methods previously reported by Hua et al in 2018 [7,9]. e subjects were given individual ID numbers to assure anonymity.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, the acid load imposed by a modern diet is thought to play an important role in the pathophysiology of osteoporosis. Recently, several studies have investigated the effects of nutrients on bone metabolism and bone mineral density (BMD), with the chelation of citric acid receiving attention in this field [6][7][8]. ose studies indicated that the chelating action of citric acid induces an increase in resorption of potassium and calcium (Ca), leading to the induction of beneficial effects toward BMD and metabolism.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lemon Beverage Containing Citric Acid with Calcium Supplementation on Bone Metabolism and Mineral Density in Postmenopausal Women: Double-Blind 11-Month Intervention Study

Ito

Iida

Hiramitsu³

et al. 2021

Journal of Nutrition and Metabolism

View full text Add to dashboard Cite

A critical factor for preventing osteoporosis after menopause is attenuation of the accelerated turnover rate of bone metabolism. The present randomized controlled study was conducted to clarify the effects of a lemon beverage with calcium (Ca) supplementation that makes use of the chelating action of citric acid. Comprehensive evaluations of bone were performed by assessments of bone mineral density (BMD) and biomarkers related to bone turnover. Seventy-nine postmenopausal women were enrolled and asked to participate in an 11-month continuous intake of the test beverages. The subjects were divided into three groups: those who consumed a lemon beverage containing citric acid with Ca supplementation (LECA group), those who consumed a lemon beverage containing citric acid without Ca supplementation (LE group), and those who consumed no test beverage (control group). Using a double-blind protocol, subjects in the LECA and LE groups consumed one bottle containing 290 mL of the test beverage each day. The ratio of change in BMD after 11 months was significantly higher in the LECA group as compared to the control and LE groups. The LECA group also showed significant decreases in concentrations of tartrate-resistant acid phosphatase 5b (TRACP-5b), a bone resorption marker, and bone alkaline phosphatase (BAP) as compared to the other groups, as well as a significant decrease in concentration of osteocalcin (OC), a bone formation marker, as compared to the LE group. Based on our findings, we speculated that bone resorption and bone formation in postmenopausal women might be suppressed along with an increase in Ca resorption caused by chelation of citric acid in association with continuous ingestion of a Ca-supplemented lemon beverage containing citric acid, resulting in suppression of high bone metabolic turnover. In addition, the results provide information regarding BMD maintenance in the bones of the trunk, including the lumbar spine and proximal femur.

show abstract

“…In particular, the protective effects of the P. yezoensis peptide PYP15 against dexamethasone-induced myotube atrophy was revealed [3]. The effect of the Chlorella pyrenoidosa protein hydrolysate (CPPH) and Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) on calcium absorption and gut microbiota composition was evaluated [4]. It was demonstrated that CPPH-Ca could promote calcium absorption partially through regulating specific gut microbiota and modulating expressions of the calcium absorption-related genes in kidney.…”

mentioning

confidence: 99%

“…It was demonstrated that CPPH-Ca could promote calcium absorption partially through regulating specific gut microbiota and modulating expressions of the calcium absorption-related genes in kidney. Therefore, CPPH-Ca may be used to promote the calcium absorption and reduce the risk of calcium deficiency [4]. Two novel angiotensin-converting enzyme (ACE) inhibitory peptides were identified in the Gracilariopsis lemaneiformis protein hydrolysate.…”

mentioning

confidence: 99%

Structure, Function, and Therapeutic Potential of Marine Bioactive Peptides

Ovchinnikova

2019

Marine Drugs

View full text Add to dashboard Cite

show abstract

Effect of Chlorella Pyrenoidosa Protein Hydrolysate-Calcium Chelate on Calcium Absorption Metabolism and Gut Microbiota Composition in Low-Calcium Diet-Fed Rats

Cited by 33 publications

References 90 publications

Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones

Spirulina Enhances Bone Modeling in Growing Male Rats by Regulating Growth-Related Hormones

Effects of Lemon Beverage Containing Citric Acid with Calcium Supplementation on Bone Metabolism and Mineral Density in Postmenopausal Women: Double-Blind 11-Month Intervention Study

Structure, Function, and Therapeutic Potential of Marine Bioactive Peptides

Contact Info

Product

Resources

About