Effect of chlorine dioxide and sodium hypochlorite on the dissolution of human pulp tissue – An in vitro study

Comparison of human pulp tissue dissolution capacities of different irrigating solutions: An in vitro study

“…The pulp specimen was then refrigerated for 1 h to assist in sectioning. [9] Digital analytical balance used for weighing the samples was calibrated every time to increase the degree of precision. Before weighing, the tissue samples were blotted dry using a filter paper.…”

“…Hence, the need for finding an alternative to NaOCl has been raised in various studies. [3,8,9] Chlorine dioxide (ClO 2 ) has currently emerged and gained attention as a possible alternative to NaOCl. It is chemically similar to NaOCl, but is less toxic since it does not form chlorinated hydrocarbons on contact with the organic matter.…”

“…[3] It has also been reported as tuberculocidal, bactericidal, virucidal and fungicidal. [9] However, studies concerning human pulp tissue dissolution capacity of ClO 2 are lacking.…”

Efficacy of Chlorine Dioxide as an Endodontic Irrigant for Pulp Dissolution in vitro

“…However, one disadvantage is its high cytotoxicity on periradicular tissues and oral mucosa. In addition to, NaOCl is reported to form chlorinated hydrocarbons known to be carcinogenic (Cobankara et al, 2010;Singh et al, 2012).…”

“…Chlorine dioxide (ClO 2 ) may be a potential alternative for endodontic treatments as a root canal irrigant, as it shows antimicrobial properties, low toxicity, and the non-production of by-products. However, there is minimal information on the percentage of chlorine dioxide suitable for the dissolution of the pulp tissue (Singh et al, 2012). Previous studies used different concentrations of ClO 2 capable of dissolving tissues where it was compared with NaOCl (Cobankara et al, 2010;Singh et al, 2012;Herczegh et al, 2013;Baisawala et al, 2018).…”