Effect of Chromium on Glucose and Lipid Profiles in Patients with Type 2 Diabetes; A Meta-analysis Review of Randomized Trials

Abstract

-Purpose. Chromium (Cr) as an essential trace element in metabolism of carbohydrate, lipid and protein is currently prescribed to control diabetes mellitus (DM). The objective of this meta-analysis was to compare the effect of Cr versus placebo (Pl) on glucose and lipid profiles in patients with type 2 DM. Methods. Literature searches in PubMed, Scopus, Scirus, Google Scholar and IranMedex was made by use of related terms during the period of 2000-2012. Eligible studies were randomized clinical trials (RCTs) with intake of Cr higher than 250 µg at least for three months in type 2 DM. Glycated hemoglobin (HbA1c), fasting blood sugar (FBS), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglyceride (TG), and body mass index (BMI) were the main outcomes. Results. Seven out of 13 relevant studies met the criteria and were included in the meta-analysis.

Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

“…Recently, micronutrient supplementation is proposed for improved metabolic profiles in PCOS women [8] . Chromium is an essential element that is involved in the metabolism of carbohydrates and lipid [9] . Data on mineral levels in patients with PCOS have not been adequately addressed.…”

Triglyceride lowering by chromium picolinate in type 2 diabetic people

“…However, in other studies, Cr fails to affect blood glucose values (Abdollahi et al, 2013;Lee and Reasner, 1994;Preuss et al, 2000;Uusitupa et al, 1983). If Cr does indeed function as an essential nutrient, these variations could arise due to variations in the subjects' Cr status.…”

“…In people with diabetes, Cr supplementation has produced a decrease in fasting blood glucose values (Abdollahi et al, 2013;Bahijiri et al, 2000;Geohas et al, 2007;Pei et al, 2006;Rabinovitz et al, 2004). However, in other studies, Cr fails to affect blood glucose values (Abdollahi et al, 2013;Lee and Reasner, 1994;Preuss et al, 2000;Uusitupa et al, 1983).…”

“…Cr supplementation can affect blood glucose, total cholesterol, HDL and triglycerides in some circumstances (Abdollahi et al, 2013;Anderson et al, 1997;Cefalu and Hu, 2004;Heimbach and Anderson, 2005;Morris et al, 1999). This has led to classifying Cr as an essential nutrient (Anderson, 1998b), though others have suggested that Cr acts only as a drug in some unhealthy situations (Vincent, 2013).…”

Total phenolic compounds, antioxidant potential and α-glucosidase inhibition by Tunisian Euphorbia paralias L.

“…In 2013, 382 million of population in the world is living with DM, 90% of them were affected by type 2 diabetes, and the number is predicted to raise to 592 million by 2035 with the growth of urbanization, improvement of living standard and modifications of humans' diet practice [1,2]. The usable synthetic medicines for the curing of DM mainly are pricey and engender dangerous side impacts [3,4]. The detection of medicinal plants for new therapeutic products is, thus, a considerable object for researchers.…”