Effect of Cisplatin on Transepithelial Resistance and Ion Transport in the A6 Renal Epithelial Cell Line

Faurskov, Brian; Bjerregaard, Henning F.

doi:10.1016/s0887-2333(99)00026-0

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…To examine the effect of 3a-s on the anti-tumor activity of cisplatin, the in vitro anti-proliferation activity of cisplatin was compared to that of cisplatin plus 3a-s. Following the literature, HeLa and HL60 cell-based anti-proliferation MTT assays were conducted, and 8 mM of cisplatin, which was appropriately higher than the reported IC 50 , [21][22][23] or 8 mM of cisplatin plus 8 mM of one of 3a-s were used. The inhibition data are shown in Fig.…”

Section: Effect Of 3a-s On the Anti-tumor Activity Of Cisplatinmentioning

confidence: 99%

Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice

et al. 2011

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A series of chelants (3a-s) composed of a glucosyl tail, an amino acid side chain and a dithiocarbamate group were designed, synthesized, and evaluated. By co-administering with cisplatin, 3a-s were able to decrease the accumulation of platinum in the organs, maintain the accumulation of platinum in the tumor tissues, and increase the urinary and fecal platinum, as well as increasing the voided volume of the treated S180-bearing mice. Compared to S180-bearing mice treated with cisplatin alone, the co-administered mice lost no spleen, kidney, liver, brain and heart weights, lost less body weight, and showed no increase in tumor weight.

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Section: Effect Of 3a-s On the Anti-tumor Activity Of Cisplatinmentioning

confidence: 99%

Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice

et al. 2011

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Cisplatin influences the skin ion transport – An in vitro study

Hołyńska-Iwan

Sobiesiak

2020

Biomedicine & Pharmacotherapy

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Effect of diabetes on biodistribution, nephrotoxicity and antitumor activity of cisplatin in mice

Faria

Santos

Rodrigues

et al. 2015

Chemico-Biological Interactions

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Both types of diabetes are associated with higher incidence of some types of cancer. Treating cancer in diabetic patients without aggravating diabetes-related complications is a challenge for clinicians. Additionally, little is known about how diabetes affects the treatment of cancer. One of the most effective chemotherapeutic drugs is cisplatin, which is nephrotoxic. Studies suggest that diabetes acts as a protective factor against the nephrotoxicity of cisplatin, but the mechanisms involved have not been elucidated yet. This renal protection has been attributed to decreased accumulation of cisplatin in the kidneys, which could be associated with deficient active transport of proximal tubular cells or to pharmacokinetic alterations caused by diabetes. However, it is uncertain if diabetes also compromises the antitumor activity of cisplatin. To address this issue, we developed a mouse model bearing cisplatin-induced nephrotoxicity, Sarcoma 180 and streptozotocin-induced diabetes. Four groups of treatment were defined: (i) control, (ii) diabetic, (iii) cisplatin and (iv) diabetic treated with cisplatin. The following parameters were evaluated: renal function, oxidative stress, apoptosis, renal histopathology, tumor remission, survival rate, genotoxicity and platinum concentration in tumor and several organs. Results indicate that diabetes protects against the renal damage induced by cisplatin, while also compromises its antitumor effectiveness. This is the first study to demonstrate this effect.

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Effect of Cisplatin on Transepithelial Resistance and Ion Transport in the A6 Renal Epithelial Cell Line

Cited by 4 publications

References 21 publications

Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice

Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice

Cisplatin influences the skin ion transport – An in vitro study

Effect of diabetes on biodistribution, nephrotoxicity and antitumor activity of cisplatin in mice

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