Effect of Clonidine on Nicotinic-Acid Flushing

Sigroth, K

doi:10.1016/s0140-6736(74)91404-4

Cited by 11 publications

(1 citation statement)

References 7 publications

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“…T h e ability of clonidine to moderate the sweating and flushing symptoms has been attributed to its a-sympathomimetic action at the level of the central nervous system. This reduces by reflex action the sensitivity of the hyperactive peripheral blood vessels to various stimuli of such low doses that they do not affect the blood pressure to any appreciable extent (6,(8)(9)(10)12).…”

Section: Discussionmentioning

confidence: 99%

Clonidine in the Treatment of Menopausal Symptoms

Salmi

Punnonen

1979

Intl J Gynecology & Obste

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Thirty-seven women complaining of hot flushes, sweating and other menopausal symptoms were treated with clonidine. A double-blind crossover trial with placebo controls was undertaken. The clonidine dose was 2 X 0.025 mg/24 hours-0.075 mg/24 hours, increased if necessary at intervals of two weeks. The effect of clonidine did not differ significantly from placebo effect in the treatment of the symptoms. Side effects during clonidine management were slight and no difference was seen in their incidence compared with that in the patients treated with the placebo. A definitive placebo response was perceivable in the decreasing of symptoms.

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Section: Discussionmentioning

confidence: 99%

Clonidine in the Treatment of Menopausal Symptoms

Salmi

Punnonen

1979

Intl J Gynecology & Obste

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Effect of Subdepressor Clonidine on Flushing Reactions in Rosacea

Wilkin¹

1983

Arch Dermatol

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Interactions of Clonidine and Nifedipine in Moderately Severe Hypertensive Patients

Mitrović

Bruchhausen

et al. 1991

The Journal of Clinical Pharma

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In ten patients (age: 47-59 yr) with moderately severe essential hypertension, the humoral and hemodynamic effects of a 4-day therapy with 2 x 75 micrograms clonidine, 2 x 20 mg nifedipine (slow-release), and their combination were investigated and compared with baseline values. The following measurements were observed under clonidine (C), nifedipine (N), and on combination (C/N), respectively: heart rate fell significantly under C from a mean of 79 to 67/min (P less than .05), increased to 73/min after N (P greater than .05) and fell again to 68/min under combination (P less than .05). Systolic blood pressure (Riva-Rocci method) decreased from a mean of 184 to 171 (C), 168 (N) and 161 mm Hg (C/N), respectively (P less than .01). Diastolic blood pressure was also significantly altered (113 vs. 104 (C), 107 (N), and 100 mm Hg (C/N); P less than .05). Stroke volume (ECHO) was not altered significantly (77 vs. 71 (C), 79 (N), and 80 mL (C/N), respectively), whereas cardiac output dropped from 5.9 to 4.9 L/min (C; P less than .05), increased to 5.7 (N; P greater than .05), and dropped again to 5.3 L/min (C/N; P greater than .05). Peripheral vascular resistance increased from a mean of 2091 to 2297 (C), fell to 1933 (N), and increased again to 2138 dyn/sec/cm-5 (C/N). Plasma norepinephrine levels fell from 440 to 281 (C; P less than .01), increased to 391 (N; P greater than .05), and fell again to 404 pg/mL (C/N; P greater than .05).(ABSTRACT TRUNCATED AT 250 WORDS)

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Effect of Clonidine on Nicotinic-Acid Flushing

Cited by 11 publications

References 7 publications

Clonidine in the Treatment of Menopausal Symptoms

Clonidine in the Treatment of Menopausal Symptoms

Effect of Subdepressor Clonidine on Flushing Reactions in Rosacea

Interactions of Clonidine and Nifedipine in Moderately Severe Hypertensive Patients

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