Effect of combined histamine H1 and H3 receptor blockade on cutaneous microvascular permeability elicited by compound 48/80

Involvement of Histamine Released From Mast Cells in Acute Radiation Dermatitis in Mice

“…3). Previous reports suggested that chlorpheniramine inhibited the compound 48 / 80-induced skin reaction and scratching behavior via H 1 -receptor antagonistic action (10,11). These results suggested that histamine released from mast cells and H 1 receptors are involved in the development of radiationinduced erythema and edema.…”

Mast cell modulation of the vascular and lymphatic endothelium

“…In support of this, antihistamines effectively reduce vascular permeability occurring with pharmacologic MC activation. 13 The half-life of histamine is ϳ 1 minute. 14 Thus, it exerts its effects quickly, and these effects also resolve quickly.…”

The cannabinoid CB2 receptor selective agonist JWH133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of β-hexosaminidase from skin slices in vitro

“…Since compound 48/80-induced plasma extravasation involves the activation of histamine H 1 receptors (see Owen et al, 1980;McLeod et al, 2005), the ability of the compounds to inhibit the binding of 2 nM [ 3 H]pyrilamine to mouse brain histamine H 1 receptors was investigated and compared with a positive control, the H 1 receptor antagonist diphenhydramine. Over the concentration range tested (10 nM -10 AM), JWH133 did not inhibit the specific binding of [ 3 H]pyrilamine, in contrast to the effects of diphenhydramine (Fig.…”