Effect of combined local treatment with zoledronic acid and basic fibroblast growth factor on implant fixation in ovariectomized rats

Gao, Ying; Luo, En; Hu, Jing; Xue, Jianming; Zhu, Songsong; Li, Jihua

doi:10.1016/j.bone.2008.10.054

Cited by 105 publications

(82 citation statements)

References 37 publications

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“…The increased percentage osteointegration effects were found by ZOL treatment significantly. The study concluded that local application of ZOL or bFGF may improve implant fixation, and the combined treatment has more beneficial effects on osteointegration, peri-implant bone formation, and maximum force than either intervention alone (Gao et al, 2009). …”

Section: Implantsmentioning

confidence: 98%

Bisphosphonates: therapeutics potential and recent advances in drug delivery

et al. 2014

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Context: Bisphosphonates (BPs) are widely used for prevention and treatment of osteoporosis. BPs are known as gold standard for osteoporosis (OP) treatment due to their positive results in clinical studies. But some serious side effects are associated with BPs like gastrointestinal adverse effect i.e. esophagitis and ulcer of esophagus. Oral bioavailability (BA) of BPs ranges from 0.6 to 1% due to poor absorption through gastrointestinal tract (GIT). Objective: The main objective of this review is to explore the role of novel drug delivery systems (DDSs) for the delivering of BPs and minimizing the drawbacks associated with them. Methods: The current review is focusing on classification, mechanism of action, and limitations of BPs, and is also dwelling on the use of novel DDSs like nanoparticles, liposomes, topical, transdermal systems, implants, bisphosphonate osteotropic DDS (BP-ODDS), microspheres, and calcium phosphate cements (CPCs) for BPs. This review also gives a critically reviewed compilation of the various in vitro and in vivo studies conducted till date. Conclusion: On the basis of the exhaustive literature, it has been found that the novel DDS minimizes the side effects associated with BPs and enhances the BA. The advance drug delivery has a greater impact on reducing the undesirable effects and increasing the BA of BPs.

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Section: Implantsmentioning

confidence: 98%

Bisphosphonates: therapeutics potential and recent advances in drug delivery

et al. 2014

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“…Different strategies employed for binding BPs to coated titanium. 60,131,[158][159][160][161][162][163][164] Color images available online at www.liebertonline.com/teb 332 CATTALINI ET AL. formation of an HA layer on the surface of bioactive inorganic scaffolds.…”

Section: Discussionmentioning

confidence: 99%

“…60,131,159,158,160,161,165 The most common strategy that produces the chemical association of BPs with the CaPs coating is by soaking the implants in a BPs solution (Fig. 3) 60,131,[158][159][160][161][162][163][164] Other strategies that produce the chemical association of BPs with CaPs reported include bisphosphonate adsorption onto plasma-sprayed HA and simulated body fluidgrown HA coatings that are commonly used for orthopedic implants. 131,158,164 Table 3 summarizes different methods for titanium surface modification that have been used for BPs fixation.…”

Section: Role Of Bps As Coatings For Improved Fixation Of Orthopedic mentioning

confidence: 99%

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Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants

Cattalini

Boccaccını

Lucangioli

et al. 2012

Tissue Engineering Part B: Reviews

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Bisphosphonates (BPs) are a group of well-established drugs that are applied in the development of metabolic bone disorder-related therapies. There is increasing interest also in the application of BPs in the context of bone tissue engineering, which is the topic of this review, in which an extensive overview of published studies on the development and applications of BPs-based strategies for bone regeneration is provided with special focus on the rationale for the use of different BPs in three-dimensional (3D) bone tissue scaffolds. The different alternatives that are investigated to address the delivery and sustained release of these therapeutic drugs in the nearby tissues are comprehensively discussed, and the most significant published approaches on bisphosphonateconjugated drugs in multifunctional 3D scaffolds as well as the role of BPs within coatings for the improved fixation of orthopedic implants are presented and critically evaluated. Finally, the authors' views regarding the remaining challenges in the fields and directions for future research efforts are highlighted.

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“…One of the most promising approaches to develop in recent years is the local delivery of anti-resorptive drugs such as bisphosphonates (BPs) in the periimplant bone. Many studies have shown that this strategy can locally enhance the bone density and therefore increase the mechanical stability of implants in animals and humans (Peter et al, 2006;Andersson et al, 2010;Gao et al, 2009;Abtahi et al, 2012). The improvement of implant anchorage was typically measured in most of the published studies with terminal ex vivo mechanical tests such as pullout, pushout test or torque testing.…”

Section: Introductionmentioning

confidence: 99%

Time course of bone screw fixation following a local delivery of Zoledronate in a rat femoral model – A micro-finite element analysis

Kettenberger

Latypova

Terrier

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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Hydrogel BisphosphonateScrew fixation microCT microFE a b s t r a c t A good fixation of osteosynthesis implants is crucial for a successful bone healing but often difficult to achieve in osteoporotic patients. One possible solution to this issue is the local delivery of bisphosphonates in direct proximity to the implants, A critical aspect of this method, that has not yet been well investigated, is the time course of the implant fixation following the drug release. Usual destructive mechanical tests require large numbers of animals to produce meaningful results. Therefore, a micro-finite element (microFE) approach was chosen to analyze implant fixation. In vivo micro computed tomography (microCT) scans were obtained, first weekly and later bi-weekly, after implantation of polymeric screws in the femoral condyles of ovariectomized rats. In one half of the animals, Zoledronate was released from a hydrogel matrix directly in the peri-implant bone stock, the other animals were implanted only with screws as control. The time course of the implant fixation was investigated with linear elastic microFE models that were created based on in vivo microCT scans. The numerical models were validated against experimental pullout-tests measurements in an additional cadaver study. The microFE analysis revealed a significant increase in force at yield of the Zoledronate treated group compared to the control group. The force of the treated group was 28% higher after 17 days of screw implantation, 42% higher after 31 days. The significant difference persisted until the end of the in vivo study at day 58 (po0.01). The early onset and prolonged duration of the implant anchorage improvement that was found in this study indicates the great potential of Zoledronate-loaded hydrogel for an enhancement of osteosynthesis implant fixation in impaired bone.

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Effect of combined local treatment with zoledronic acid and basic fibroblast growth factor on implant fixation in ovariectomized rats

Cited by 105 publications

References 37 publications

Bisphosphonates: therapeutics potential and recent advances in drug delivery

Bisphosphonates: therapeutics potential and recent advances in drug delivery

Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants

Time course of bone screw fixation following a local delivery of Zoledronate in a rat femoral model – A micro-finite element analysis

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