2012
DOI: 10.2147/ijn.s35648
|View full text |Cite
|
Sign up to set email alerts
|

Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion

Abstract: Purpose:To study the effects of varying lipid concentrations, lipid and oil ratio, and the addition of propylene glycol and lecithin on the long-term physical stability of nanostructured lipid nanocarriers (NLC), skin hydration, and transepidermal water loss. Methods: The various NLC formulations (A1-A5) were prepared and their particle size, zeta potential, viscosity, and stability were analyzed. The formulations were applied on the forearms of the 20 female volunteers (one forearm of each volunteer was left … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
53
0
2

Year Published

2012
2012
2025
2025

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 62 publications
(56 citation statements)
references
References 36 publications
1
53
0
2
Order By: Relevance
“…Due to occlusion, water evaporation from the skin to the atmosphere is decreased and water is thus retained within the skin. The stratum corneum swells, which leads to a drug penetration enhancing effect (Jenning et al, 2000;Wissing et al, 2001;Loo et al, 2013).…”
Section: In Vitro Studymentioning
confidence: 99%
“…Due to occlusion, water evaporation from the skin to the atmosphere is decreased and water is thus retained within the skin. The stratum corneum swells, which leads to a drug penetration enhancing effect (Jenning et al, 2000;Wissing et al, 2001;Loo et al, 2013).…”
Section: In Vitro Studymentioning
confidence: 99%
“…Neste estudo, foram utilizados dois métodos para avaliar a variação na hidratação da pele, após uma única aplicação ou aplicação diária das formulações contendo ou não α-bisabolol (F2), extracto de camomila (F3) e apigenina (F4): a) teor de água do estrato córneo, que o foi medido utilizando um medidor de capacidade de pele e b) perda transepidérmica de água (PTEA) que foi medida com um evaporímetro. De acordo com Loo et al (24), a PTEA é um bom indicador da função de barreira do estrato córneo prejudicada. Um aumento na PTEA indica uma perturbação no estra-dermal water loss on the forearm of the volunteers, especially the formulation containing chamomile extract.…”
Section: Discussionunclassified
“…The dry NLC system coated with Aurum before counted in vacuum condition. Particle morphology examination observed at 10.000× magnification [4].…”
Section: Physical and Chemical Characterization Of Coenzyme Q10 Nlc Smentioning
confidence: 99%
“…It is composed of a long side chain containing 10 isoprenoid units. Due to its structure, the aqueous solubility is very low, causing a low oral bioavailability [4]. In terms of cosmetic applications, this active has shown the ability to reduce photoaging in vivo with a corresponding decrease in wrinkle depth [5][6][7].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation