Effect of Cordycepin Purified from Cordyceps militaris on Th1 and Th2 Cytokines in Mouse Splenocytes

Jeong, Min-Ho; Seo, Min Jeong; Park, Jeong Uck; Kang, Byoung Won; Kim, Kyoung-Sook; Lee, Jae Yun; Kim, Gi‐Young; Kim, Jung-In; Choi, Yung Hyun; Kim, Kwang Hyuk; Jeong, Yong Kee

doi:10.4014/jmb.1203.03039

Cited by 30 publications

(14 citation statements)

References 15 publications

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“…Jeong et al . also demonstrated that cordycepin increases the levels of different cytokines in vitro , contributing to the enhancement of immunity69. The Th2 cell activation results in B cell maturation which consistent with the B cell classification experiments.…”

Section: Discussionsupporting

confidence: 82%

Systems Pharmacology-based strategy to screen new adjuvant for hepatitis B vaccine from Traditional Chinese Medicine Ophiocordyceps sinensis

Wang

Liu

et al. 2017

Sci Rep

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Adjuvants are common component for many vaccines but there are still few licensed for human use due to low efficiency or side effects. The present work adopted Systems Pharmacology analysis as a new strategy to screen adjuvants from traditional Chinese medicine. Ophiocordyceps sinensis has been used for many years in China and other Asian countries with many biological properties, but the pharmacological mechanism has not been fully elucidated. First in this study, 190 putative targets for 17 active compounds in Ophiocordyceps sinensis were retrieved and a systems pharmacology-based approach was applied to provide new insights into the pharmacological actions of the drug. Pathway enrichment analysis found that the targets participated in several immunological processes. Based on this, we selected cordycepin as a target compound to serve as an adjuvant of the hepatitis B vaccine because the existing vaccine often fails to induce an effective immune response in many subjects. Animal and cellular experiments finally validated that the new vaccine simultaneously improves the humoral and cellular immunity of BALB/c mice without side effects. All this results demonstrate that cordycepin could work as adjuvant to hepatitis b vaccine and systems-pharmacology analysis could be used as a new method to select adjuvants.

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Section: Discussionsupporting

confidence: 82%

Systems Pharmacology-based strategy to screen new adjuvant for hepatitis B vaccine from Traditional Chinese Medicine Ophiocordyceps sinensis

Wang

Liu

et al. 2017

Sci Rep

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“…However, using mouse splenocytes, Jeong et al found that Cordyceps enhanced both cellular and humoral immunity: in the Cordyceps administered group, IL-12 increased by 2.9 times and IL-4 and IL-10 in the Th2 cytokine cluster increased by 1.9 times and 1.8 times, respectively. 24 Therefore, conduct of additional studies of the Th2 cytokines responses is needed.…”

Section: Discussionmentioning

confidence: 99%

Cordyceps militarisEnhances Cell-Mediated Immunity in Healthy Korean Men

Kang

Baik

Kim

et al. 2015

Journal of Medicinal Food

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Cordyceps militaris is a mushroom traditionally used for diverse pharmaceutical purposes in East Asia, including China, and has been found to be effective for enhancing immunity through various types of animal testing. The aim of this study is to determine the efficacy of C. militaris for enhancing cell-mediated immunity and its safety in healthy male adults. Healthy male adults were divided into the experimental group (n = 39), given 1.5 g/day of ethanol treated C. militaris in capsules, and the control group (n = 40), given the same number of identical placebo capsules filled with microcrystalline cellulose and lactose for 4 weeks from February 13 to March 14, 2012; the natural killer (NK) cell activity, lymphocyte proliferation index (PI), and T-helper cell 1 (Th1) cytokine cluster (interferon [IFN]-γ, interleukin [IL]-12, IL-2, and tumor necrosis factor [TNF]-α) were measured, along with stability test, at weeks 0, 2, and 4. The C. militaris group showed a statistically significant greater increase in NK200 (P = .0010), lymphocyte PI (P ≤ .0001), IL-2 (P = .0096), and IFN-γ (P = .0126), compared with the basal level, than the placebo group. There was no statistically significant adverse reaction. C. militaris enhanced the NK cell activity and lymphocyte proliferation and partially increased Th1 cytokine secretion. Therefore, C. militaris is safe and effective for enhancing cell-mediated immunity of healthy male adults.

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“…Due to the absence of oxygen in the 3 0 -position of its ribose moiety, the incorporation of cordycepin during RNA synthesis results in termination of chain elongation (16,17). Cordycepin has been reported to have various pharmacological properties, such as antioxidant (18,19), immunomodulatory (20,21) and anti-inflammatory effects (22e26), Moreover, this compound displays potent cytotoxicity against a variety of human cancer cells (17,27e29). Our studies have demonstrated that cordycepin induces apoptosis in human leukemia and prostate carcinoma cells through activation of reactive oxygen species-dependent caspases (30,31).…”

mentioning

confidence: 99%

Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT

Jang

Kwon

Jeong

et al. 2015

Journal of Bioscience and Bioengineering

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Effect of Cordycepin Purified from Cordyceps militaris on Th1 and Th2 Cytokines in Mouse Splenocytes

Cited by 30 publications

References 15 publications

Systems Pharmacology-based strategy to screen new adjuvant for hepatitis B vaccine from Traditional Chinese Medicine Ophiocordyceps sinensis

Systems Pharmacology-based strategy to screen new adjuvant for hepatitis B vaccine from Traditional Chinese Medicine Ophiocordyceps sinensis

Cordyceps militarisEnhances Cell-Mediated Immunity in Healthy Korean Men

Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT

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