Effect of Curcuma xanthorrhiza Gel on Methicillin-Resistant Staphylococcus aureus-Infected Second-Degree Burn Wound in Rats

Kesumayadi, Irfan; Almas, Ayyasi Izaz; Rambe, Ilham Nur Hakim; Hapsari, Rebriarina

doi:10.20307/nps.2021.27.1.1

Cited by 6 publications

(6 citation statements)

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“…The specimens were then processed with haematoxylin and eosin (HE) staining. 7 The number of fibroblast cells in the specimen was counted using a binocular microscope at 400 times magnification. Three different fields of view were examined.…”

Section: Methodsmentioning

confidence: 99%

“…5,6 Temulawak (Curcuma xanthorrhiza) is an herbal plant commonly used as traditional medicine in Indonesia. 7 Curcuma xanthorrhiza contains alkaloid, flavonoid, phenolic, and curcumin, as well as other substances with promising abilities in increasing fibroblast cell count. [7][8][9] Previous studies have stated that Curcuma xanthorrhiza extract is effective in accelerating the healing progress of a second-degree burn wound.…”

Section: Introductionmentioning

confidence: 99%

“…7 Curcuma xanthorrhiza contains alkaloid, flavonoid, phenolic, and curcumin, as well as other substances with promising abilities in increasing fibroblast cell count. [7][8][9] Previous studies have stated that Curcuma xanthorrhiza extract is effective in accelerating the healing progress of a second-degree burn wound. 8,[10][11][12] In their research, 5% Curcuma xanthorrhiza extract showed a significant result with a 40% wound closure rate on the 9 th day, as proved by the formation of granulation tissue.…”

Section: Introductionmentioning

confidence: 99%

“…8,[10][11][12] In their research, 5% Curcuma xanthorrhiza extract showed a significant result with a 40% wound closure rate on the 9 th day, as proved by the formation of granulation tissue. 7 The granulation tissue is a result of fibroblast proliferation and angiogenesis, which aid in faster wound closure. Another study on 5% Curcuma xanthorrhiza extract also showed that the application of the extract increased the number of fibroblasts, tissue granulation, blood vessel density, and wound contraction in male diabetic Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

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Effectivity of 5% Temulawak Extract (Curcuma xanthorrhiza) on Post-Extraction Fibroblast Cells in Wistar Rats (Rattus norvegicus)

Anggayanti,

Sudirman,

Paramita

2023

Padjadjaran J Dent

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Introduction: Socket wound would undergo 3 phases of wound-healing process, i.e. inflammation phase, proliferation phase, and re-modelling phase. In proliferation phase, fibroblast cells were important for producing collagen and elastic cells. One of natural ingredients believed to stimulate fibroblasts is Curcuma xanthorriza. The active compounds in curcuma, namely curcumin and flavonoid, had the ability to increase fibroblast migration and accelerate wound healing. This study aims to observe the effectivity of 5% temulawak extract (Curcuma xanthorrhiza) on post-extraction fibroblast cells in Wistar rats (Rattus norvegicus). Methods: The experiment was conducted on 30 rats that were divided into 2 groups, control group and experimental group. Each group of rats were given intermuscular anesthesia and underwent mandibular incisors extraction. The experiment group was given intermuscular injection of 5% curcuma extract into their wound socket, while control group were given placebo gel injection. On day 3, 5, and 7 decapitation was performed to get the mandibular samples. Furthermore, the number of fibroblast cells was observed using a light microscope with 3 different fields of view at 400 times. Results: The results showed that the mean number of fibroblasts in the experiment group was higher than the control group. Conclusion: 5% temulawak extract (Curcuma xanthorrhiza) had significant effect on increasing post-extraction fibroblast cells in Wistar rats (Rattus norvegicus).

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effectivity of 5% Temulawak Extract (Curcuma xanthorrhiza) on Post-Extraction Fibroblast Cells in Wistar Rats (Rattus norvegicus)

Anggayanti,

Sudirman,

Paramita

2023

Padjadjaran J Dent

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“…Curcumin, a natural dietary polyphenol, has exhibited diverse biological and pharmacological effects, including anti-aging benefits. Meanwhile, a potential anti-aging compound known as xanthorrhizol has shown its ability to dramatically lower metalloproteinase-1 (MMP-1) expression and boost type 1 procollagen production (Vaiserman et al 2020, Irfan et al 2021. Therefore, this study aimed to ascertain whether temulawak extract, a potential candidate for a cosmeceutical ingredient, has anti-aging properties that can inhibit the enzymes elastase, hyaluronidase, and tyrosinase.…”

Section: Introductionmentioning

confidence: 99%

Anti-Aging Properties of Temulawak Extract (Curcuma xanthorrhiza L.) by In Vitro Assay

Teresa Liliana Wargasetia,

Wahyu Widowati,

Anis Syabani Muthmainnah

et al. 2023

FMI

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Highlights:1. Elastase, hyaluronidase, and tyrosinase can all be inhibited by temulawak extract.2. Temulawak extract has strong anti-aging ability and can be used as a candidate for cosmetic applications. AbstractThe process of aging is the gradual loss of a tissue's capacity to heal and maintain normal or physiological form and function. Elastase, hyaluronidase, and tyrosinase are the enzymes that contribute to skin aging. The anti-aging effect is connected to the inhibition of these enzymes' activity. Many medicinal plants with active metabolite have been utilized extensively to treat aging. Active compounds of temulawak (Curcuma xanthorrhiza L.) such as phenolic, curcuminoid and xanthorrhizol have potential as antiaging. This study aims to determine whether temulawak extract (TE), a potential candidate for cosmeceutical agent, has anti-aging characteristics by inhibiting the elastase, hyaluronidase, and tyrosinase enzymes. TE was processedxby PT FAST. Stock solution of TE was made by dissolving 20 mg of extract with 1 ml of DMSO 100%, the stock solution was then diluted to achieve the concentrations level 31.25 - 1000 μg/ml working solution of TE. The antiaging activity assays were carried out at PT Aretha Medika Utama. In vitro antiaging assay of TE includes elastase, hyaluronidase, and tyrosinase enzyme inhibition at 7 level of various concentrations of 2.08-66.67 μg/ml for anti-elastase assay, 5.21-166.67 μg/ml for anti-hyaluronidase assay, and 3.125-100 μg/ml for anti-tyrosinase assay with three replications. SPSS software was used to conduct the statistical analysis (p<0,05 is considered significant). TE exhibited highest inhibition percentage of 82.72%, 89.41%, and 94.17% for anti-tyrosinase, anti-elastase, and anti-hyaluronidase, respectively. The median inhibitory concentration (IC50) for elastase inhibitory activity was 10.66 μg/ml, hyaluronidase 70.39 μg/ml, and tyrosinase 55.87 μg/ml. According to this study, TE can be used as cosmeceu

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Phytochemical and anti-MRSA constituents of Zanthoxylum nitidum

Zeng

Wang

Chen

et al. 2022

Biomedicine & Pharmacotherapy

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Effect of Curcuma xanthorrhiza Gel on Methicillin-Resistant Staphylococcus aureus-Infected Second-Degree Burn Wound in Rats

Cited by 6 publications

References 0 publications

Effectivity of 5% Temulawak Extract (Curcuma xanthorrhiza) on Post-Extraction Fibroblast Cells in Wistar Rats (Rattus norvegicus)

Effectivity of 5% Temulawak Extract (Curcuma xanthorrhiza) on Post-Extraction Fibroblast Cells in Wistar Rats (Rattus norvegicus)

Anti-Aging Properties of Temulawak Extract (Curcuma xanthorrhiza L.) by In Vitro Assay

Phytochemical and anti-MRSA constituents of Zanthoxylum nitidum

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