Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faeces

Abadie, Catherine; Hug, Melanie N.; Kübli, C; Gains, Nigel

doi:10.1042/bj2990725

Cited by 61 publications

(50 citation statements)

References 22 publications

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“…The assigned complex stoichiometry is supported by the studies of Abadie et al [15]. In contrast, Tan and Lindenbaum [16], and Cabrer et al [13] have reported 1:2 complexes (BS:CD) for the interaction between the dihydroxy BS TDC and GDC and b-CD.…”

Section: Complex Formation With Natural â-Cdmentioning

confidence: 83%

“…In mobility shift ACE experiments, it has been observed that the ligand induced shift in analyte mobility is dependent on the analyte concentration injected [40][41][42][43][44]56]. Consequently, it is generally recommended that a) Stability constants determined by a phase solubility technique (displacement assay) [15]. b) Stability constants determined by flow microcalorimetry [16].…”

Section: Estimation Of Stability Constantsmentioning

confidence: 99%

“…Studies investigating the interaction between CDs and BS have primarily been performed using natural CDs [13][14][15][16][17][18][19][20]. However, in the case of bioavailability enhancement the substituted CDs are of greater potential interest due to their higher aqueous solubility.…”

Section: Introductionmentioning

confidence: 99%

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Complexation of tauro‐ and glyco‐conjugated bile salts with three neutral β‐CDs studied by ACE

et al. 2007

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Complexation of the bile salts (BS) taurocholate, tauro-beta-muricholate, taurodeoxycholate, taurochenodeoxycholate, glycocholate, glycodeoxycholate, and glycochenodeoxycholate common in rat, dog, and man with natural beta-CD and the chemically modified beta-CDs 2-hydroxypropyl-beta-CD and 2-O-methyl-beta-CD was studied using mobility shift ACE. The CDs were selected due to their frequent use in preformulation and drug formulation as oral excipients for the solubilization of drug substances with low aqueous solubility. ACE was demonstrated to be a feasible and efficient technique for investigation of the interactions between BS and beta-CDs. All the investigated BS possessed affinity for the three CDs with stability constants ranging from 2x10(3) to 4x10(5) M(-) (1). The requirements and assumptions related to the use of ACE for estimating high affinity stability constants were discussed. The extent and pattern of hydroxylation significantly influenced the affinity of the glyco- and tauro-conjugated BS toward the beta-CDs (chenodeoxycholates >> deoxycholates > cholates) whereas the nature of the beta-CD derivatization and BS conjugation played a minor role only. The results indicate that displacement of drug substances from beta-CD inclusion complexes is likely to occur in the small intestine where BS are present potentially influencing drug bioavailability.

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Section: Complex Formation With Natural â-Cdmentioning

confidence: 83%

Section: Estimation Of Stability Constantsmentioning

confidence: 99%

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Complexation of tauro‐ and glyco‐conjugated bile salts with three neutral β‐CDs studied by ACE

et al. 2007

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“…The fermentation of carbohydrates by anaerobic bacteria yields short-chain fatty acids, primarily composed of acetic, propionic, and butyric acids, which can lower the lumen pH, creating an environment less conducive to the formation of cancerous tumors (7,8). Also, RS was shown to form nondigestible inclusion complexes with bile acids, attributed to the formation of a helical structure (9), and was demonstrated to be more effective than cholestyramine as a lipid-lowering agent in the rat (10). Furthermore, the fermentation end-products of RS could counteract the up-regulation of cholesterol and bile acid biosynthesis (10).…”

Section: Introductionmentioning

confidence: 99%

Structure and Function of Starch and Resistant Starch from Corn with Different Doses of Mutant Amylose-Extender and Floury-1 Alleles

Paez

White

2009

J. Agric. Food Chem.

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Four corn types with different doses of mutant amylose-extender (ae) and floury-1 (fl1) alleles, in the endosperm, including no. 1, aeaeae; no. 2, fl1fl1fl1; no. 3, aeaefl1; and no. 4,fl1fl1ae, were developed for use in making Hispanic food products with high resistant starch (RS) content. The RS percentages in the native starch (NS) of 1−4 were 55.2, 1.1, 5.7, and 1.1%, respectively. All NS were evaluated for pasting properties with a rapid viscoanalyzer (RVA) and for thermal properties with a differential scanning calorimeter (DSC). NS 1 had a low peak viscosity (PV) caused by incomplete gelatinization, whereas NS 3 had the greatest PV and breakdown of all four starch types. On the DSC, NS 2 had the lowest onset temperature and greatest enthalpy. NS 1 and 3 had similar onset and peak temperatures, both higher than those of NS 2 and 4. The gel strength of NS heated with a RVA was evaluated by using a texture analyzer immediately after RVA heating (fresh, RVA-F) and after the gel had been stored at 4 °C for 10 days (retrograded, RVA-R). NS 1 gel was watery and had the lowest strength (30 g) among starch gel types. NS 3 gel, although exhibiting syneresis, had greater gel strength than NS 2 and 4. The structures of the NS, the RS isolated from the NS (RS-NS), the RS isolated from RVA-F (RS-RVA-F), and the RS isolated from RVA-R (RS-RVA-R) were evaluated by using size exclusion chromatography. NS 1 had a greater percentage of amylose (AM) (58.3%) than the other NS (20.4−26.8%). The RS from all NS types (RS-NS) had a lower percentage of amylopectin (AP) and a greater percentage of low molecular weight (MW) AM than was present in the original NS materials. The RS-RVA-R from all starches had no AP or high MW AM. The percentages of longer chain lengths (DP 35−60) of NS were greater in 1 and 3 than in 2 and 4, and the percentages of smaller chain lengths (DP 10−20) were greater in 2 and 4 than in 1 and 3. In general, NS 3 seemed to have inherited some pasting, thermal, and structural characteristics from both NS 1 and 2, but was distinctly different from 4. Four corn types with different doses of mutant amylose-extender (ae) and floury-1 (fl1) alleles, in the endosperm, including no. 1, aeaeae; no. 2, fl1fl1fl1; no. 3, aeaefl1; and no. 4, fl1fl1ae, were developed for use in making Hispanic food products with high resistant starch (RS) content. The RS percentages in the native starch (NS) of 1-4 were 55.2, 1.1, 5.7, and 1.1%, respectively. All NS were evaluated for pasting properties with a rapid viscoanalyzer (RVA) and for thermal properties with a differential scanning calorimeter (DSC). NS 1 had a low peak viscosity (PV) caused by incomplete gelatinization, whereas NS 3 had the greatest PV and breakdown of all four starch types. On the DSC, NS 2 had the lowest onset temperature and greatest enthalpy. NS 1 and 3 had similar onset and peak temperatures, both higher than those of NS 2 and 4. The gel strength of NS heated with a RVA was evaluated by using a texture analyzer immediately after RVA heating (fresh, R...

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“…It is widely known that frequent and excessive intake of saturated fatty acids(SFA) and cholesterol increases plasma TAG and cholesterol concentrations, in particular LDL-C which is a risk factor for the development of coronary heart disease (Paul et CD is a cyclic oligosaccharide of seven glucose units all linked in a ring structure in (1 4) position (Abadie et al, 1994). CD forms an inclusion complex with cholesterol and bile acids in the gut (Riottot et al, 1993;Saenger, 1994;Yen and Chen, 2000).…”

Section: Introductionmentioning

confidence: 99%

The Biological Effects of β-Cyclodextrin on Antithrombotic Activity and Plasma Lipid Metabolism in Rats

2003

Journal of Animal Science and Technology

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The effect of feeding a cyclic oligosaccharide, -cyclodextrin( CD) on plasma cholesterol and triacylglyceride concentrations and on antithrombotic activity were investigated in rats fed a control chow diet, or one either high in cholesterol or in saturated fat. The bleeding time of CD-fed groups was significantly prolonged by 293%, 157% and 218% in normal, high cholesterol and high fat diet fed groups, respectively, as compared to the control group(p<0.05). The whole blood clotting time was significantly increased by 202%, 168% and 211% in normal, high cholesterol and high fat diet fed groups as compared to control group, respectively(p<0.05). The CD diet caused a marked decrease in plasma total lipid (TL), triacylglyceride (TAG), total cholesterol (TC) and low density lipoproteincholesterol (LDL-C) concentrations. The plasma TL concentration was significantly decreased by 70%, 82% and 87% in normal, high cholesterol and high fat diet fed groups as compared to the control group, respectively(p<0.05). The plasma TAG concentration was significantly decreased by 89%, 43% and 59% in normal, high cholesterol and high fat diet fed groups, respectively, as compared to the control group(p<0.05). The plasma TC concentration was significantly decreased by 28%, 62% and 36% in normal, high cholesterol and high fat diet fed groups, respectively, as compared to the control group(p<0.05). The LDL-C concentration was significantly decreased by 39%, 54% and 25% in normal, high cholesterol and high fat diet fed groups as compared to control group, respectively(p<0.05). The plasma total bile acids contents of CD group was significantly increased by 66%, 95% and 97% in normal, high cholesterol and high fat diet fed groups as compared to control group, respectively(p<0.05). The hepatic HMG-CoA reductase activity was significantly lowered by 41% in the CD-fed group compared to normal diet fed rats(p<0.05). The fecal steroid excretions of the CD groups was significantly increased by 167% in normal diet fed rats(p<0.05). These results suggest that the CD has a biological active function on antithrombotic activity and is hypolipidemic, hypotriglyceridemic and hypocholesterolimic agents. These are all effects that can help to prevent obesity and coronary heart disease in humans.

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Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faeces

Cited by 61 publications

References 22 publications

Complexation of tauro‐ and glyco‐conjugated bile salts with three neutral β‐CDs studied by ACE

Complexation of tauro‐ and glyco‐conjugated bile salts with three neutral β‐CDs studied by ACE

Structure and Function of Starch and Resistant Starch from Corn with Different Doses of Mutant Amylose-Extender and Floury-1 Alleles

The Biological Effects of β-Cyclodextrin on Antithrombotic Activity and Plasma Lipid Metabolism in Rats

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