Effect of daily calcitriol supplementation with and without calcium on disease regression in non-alcoholic fatty liver patients following an energy-restricted diet: Randomized, controlled, double-blind trial

Amiri, Hamzeh; Agah, Shahram; Azar, Javad Tolouei; Hosseini, Seyyed Hossein; Shidfar, Farzad; Mousavi, Seyedeh Neda

doi:10.1016/j.clnu.2016.09.020

Cited by 60 publications

(52 citation statements)

References 28 publications

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“…Some clinical studies show that daily vitamin D supplementation improves insulin resistance and related parameters in patients with NAFLD [ 54 , 55 ]. Again, vitamin D supplementation can also have positive implications on the cardiovascular system.…”

Section: Resultsmentioning

confidence: 99%

Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

2018

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Non-alcoholic fatty liver disease (NAFLD) is a clinical condition characterized by lipid infiltration of the liver, highly prevalent in the general population affecting 25% of adults, with a doubled prevalence in diabetic and obese patients. Almost 1/3 of NAFLD evolves in Non-Alcoholic SteatoHepatitis (NASH), and this can lead to fibrosis and cirrhosis of the liver. However, the main causes of mortality of patients with NAFLD are cardiovascular diseases. At present, there are no specific drugs approved on the market for the treatment of NAFLD, and the treatment is essentially based on optimization of lifestyle. However, some nutraceuticals could contribute to the improvement of lipid infiltration of the liver and of the related anthropometric, haemodynamic, and/or biochemical parameters. The aim of this paper is to review the available clinical data on the effect of nutraceuticals on NAFLD and NAFLD-related parameters. Relatively few nutraceutical molecules have been adequately studied for their effects on NAFLD. Among these, we have analysed in detail the effects of silymarin, vitamin E, vitamin D, polyunsaturated fatty acids of the omega-3 series, astaxanthin, coenzyme Q10, berberine, curcumin, resveratrol, extracts of Salvia milthiorriza, and probiotics. In conclusion, Silymarin, vitamin E and vitamin D, polyunsaturated fatty acids of the omega-3 series, coenzyme Q10, berberine and curcumin, if well dosed and administered for medium–long periods, and associated to lifestyle changes, could exert positive effects on NAFLD and NAFLD-related parameters.

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Section: Resultsmentioning

confidence: 99%

Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

2018

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“…Therefore, several researchers had studied the effects of vitamin D supplementation, both alone or combined with other ingredients. As an example, Amiri, et al showed that, in NAFLD patients, the supplementation of a mixture of vitamin D plus calcium decreased ALT and fasting plasma glucose and increased HDL-C levels compared with the group that only received vitamin D [ 102 ]. Regarding the combination of vitamin D with PUFAs, Della Corte, et al [ 92 ] performed a placebo-controlled RCT carried out with 41 children (4-16 years old) in which the effect of vitamin D plus docosahexaenoic acid (DHA) was evaluated in biopsy-proven NAFLD overweight children that had a deficiency of vitamin D. Once selected, the volunteers received a daily oral dose of vitamin D (800 IU) plus DHA (500 mg).…”

Section: Multi-ingredient Nutritional Approaches For the Treatmentmentioning

confidence: 99%

Mediterranean Diet and Multi-Ingredient-Based Interventions for the Management of Non-Alcoholic Fatty Liver Disease

et al. 2017

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Non-alcoholic fatty liver disease (NAFLD) comprises a wide spectrum of hepatic disorders, from simple steatosis to hepatic necro-inflammation leading to non-alcoholic steatohepatitis (NASH). Although the prevalence of these multifactorial pathologies is continuously increasing in the population, there is still not an established methodology for their treatment other than weight loss and a change in lifestyle habits, such as a hypocaloric diet and physical exercise. In this framework, there is increasing evidence that several food bioactives and dietary patterns are effective for reversing and preventing the onset of these pathologies. Some studies have claimed that better responses are obtained when treatments are performed under a multifaceted approach, using different bioactive compounds that act against complementary targets. Thus, in this work, current strategies for treating NAFLD and NASH based on multi-ingredient-based supplements or the Mediterranean diet, a dietary pattern rich in bioactive compounds, are reviewed. Furthermore, the usefulness of omics techniques to design effective multi-ingredient nutritional interventions and to predict and monitor their response against these disorders is also discussed.

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“…Other investigations, with different study design and outcome measures, have been conducted to unravel possible therapeutic effects of vitamin D on hepatic damage, showing contrasting results on non-specific markers of hepatic injuries, such as blood transaminases [ 33 , 34 ].…”

Section: Clinical Trialsmentioning

confidence: 99%

Vitamin D Supplementation and Non-Alcoholic Fatty Liver Disease: Present and Future

2017

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic disease throughout the Western world and is recognized as the main cause of cryptogenic cirrhosis; however, the identification of an effective therapy for NAFLD is still a major challenge. Vitamin D deficiency is a wide-spread condition which reaches epidemic proportions in industrialized countries, mainly in relation to current lifestyle and limited dietary sources. Epidemiological studies point towards an association between hypovitaminosis D and the presence of NAFLD and steatohepatitis (NASH), independently of confounders such as obesity and insulin resistance. Furthermore, several pieces of experimental data have shown the anti-fibrotic, anti-inflammatory and insulin-sensitizing properties exerted by vitamin D on hepatic cells. However, results from trials evaluating the effects of oral vitamin D supplementation on liver damage in NAFLD and NASH are controversial. The aim of this review is to give an overview of the evidence currently available from clinical trials and to discuss possible shortcomings and new strategies to be considered in future investigations.

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Effect of daily calcitriol supplementation with and without calcium on disease regression in non-alcoholic fatty liver patients following an energy-restricted diet: Randomized, controlled, double-blind trial

Cited by 60 publications

References 28 publications

Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

Mediterranean Diet and Multi-Ingredient-Based Interventions for the Management of Non-Alcoholic Fatty Liver Disease

Vitamin D Supplementation and Non-Alcoholic Fatty Liver Disease: Present and Future

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