Effect of Datura stramonium on Cyclophosphamide-induced Oxidative Stress in Albino Rats: Study on Kidney Markers

Joshua, Parker Elijah; Asomadu, Rita Onyekachukwu; Eze, C. S.; Nnamani, Ikenna Vitus; Kingsley, Chizoba Ogugofor; Nweje-Anya, Chukwuemeka Paul; Patrick, Victor Jason; Amobi, Seanpaul

doi:10.3923/ijp.2019.926.932

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…Aqueous seed extract of D. Stramonium L. has been previously reported to restore altered antioxidant enzyme activities following cyclophosphamide-induced oxidative stress in rats [ 27 ]. In the present study, induction of immunosuppression following pre-treatment with cyclophosphamide led to significant ( p < 0.05) declines in the activities of SOD, CAT and GP X (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…9 ). This could be accrued to the increased levels of free radicals generated as a result of lipid peroxidation induced by acrolein [ 27 ]. The decrease in vitamins A, C and E concentration is consistent with the work of Joshua et al [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…This could be accrued to the increased levels of free radicals generated as a result of lipid peroxidation induced by acrolein [ 27 ]. The decrease in vitamins A, C and E concentration is consistent with the work of Joshua et al [ 27 ]. Treatment with graded doses of ASEDS significantly ( p < 0.05) increased the concentration of these antioxidant vitamins, which could scavenge free radicals generated by cyclophosphamide.…”

Section: Discussionmentioning

confidence: 99%

“…Immunosuppression in Wistar rats was induced according to the protocol of Joshua et al [ 27 ]. Accordingly, 10 mg/kg b.w.…”

Section: Methodsmentioning

confidence: 99%

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Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats

et al. 2022

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Background Datura stramonium L. (Solanaceae) is used traditionally in west Africa to treat asthma, epilepsy, rheumatoid arthritis, filariasis microbial infections and conjunctivitis. This study investigated the immunomodulatory effects of aqueous seed extract of D. stramonium L. (ASEDS) on Wistar rats. Methods Thirty Wistar albino rats (180–200 g) were randomized into 6 groups (n = 5). Group 1 received distilled water only. Rats in groups 2–6 were pretreated with 10 mg/kg body weight (b.w.) Cyclophosphamide orally for 27-days to induce immunosuppression. Thereafter, they received treatment orally for 28 days as follows: Group 2 (distilled water), group 3 (5 mg/kg b.w. Levamisole), groups 4–6 (60, 90 and 120 mg/kg b.w. ASEDS, respectively). HPLC was used to determine major compounds in ASEDS. The effects of ASEDS on immune cells, immunoglobulins A, G and M levels, lipoproteins, and antioxidant status of rats were evaluated. Results ASEDS indicated high content of Acutumine, Quinine, Catechin, Chlorogenic acid, Gallic acid, Quercetin, Vanillic acid, Luteolin, Formosanin C, Saponin, Cyanidin, Tannic acid, 3-Carene, Limonene and α-terpineol. Cyclophosphamide triggered significant (p < 0.05) reduction in total leucocyte count and differentials, IgA, IgG, high-density lipoproteins (HDL), catalase, superoxide dismutase, glutathione peroxidase, vitamins A, C and E levels of untreated rats. Administration of ASEDS led to significant (p < 0.05) improvement in immune cell counts, immunoglobulin synthesis, high-density lipoprotein concentration, and antioxidant status of rats in the treated groups. Conclusions The results obtained from the study showed the immunomodulatory activity of ASEDS, thereby indicating its potential in immunostimulatory drug discovery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Immunosuppression in Wistar rats was induced according to the protocol of Joshua et al [ 27 ]. Accordingly, 10 mg/kg b.w.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats

et al. 2022

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“…Globulin was estimated indirectly by subtracting the albumin concentration from the total protein concentration. The albumin/globulin ratio was obtained by dividing the concentration of albumin by that of globulin according to Joshua et al, (2019).…”

Section: B Experimental Designmentioning

confidence: 99%

The protective role of Gallic acid in Cisplatin nephrotoxicity

Kotb

Serag

Elshaarawy

et al. 2021

Frontiers in Scientific Research and Technology

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Background: Nephrotoxicity is considered one of the most serious and dose-limiting factors for restricting clinical use of Cisplatin and anticancer efficacy. Gallic acid is a non-toxic substance that has a wide range of therapeutic roles with high antioxidant activity. So, the present study aims to investigate the concurrent protective action of Gallic acid against inflammatory and oxidative damage caused by Cisplatin in rat kidneys. Material and methods: Thirty-two male albino rats were classified into four groups, eight per each as follows: Group 1 (Normal control group): without treatment. Group 2 (Gallic acid group): healthy rats were given Gallic acid. Group 3 (Cisplatin group): healthy rats were injected with Cisplatin. Group 4 (Gallic acid + Cisplatin) treated group. Kidney functions, Paraoxonase-1, and inflammatory cytokines such as Tumor Necrosis Factor α, respectively were determined. Results: Cisplatin was induced kidney damage with a high significance (P <0.001) regarding kidney function tests and the group of Cisplatin + Gallic acid demonstrated a broad range in the prevention and/or management of kidney damage with a high significance (P <0.001) compared to cisplatin group. Conclusion: Gallic acid has a protective role against kidney dysfunction and renal damage in Cisplatin therapy.

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Examining the quaternary ammonium chitosan Schiff base-ZnO nanocomposite's potential as protective therapy for rats' cisplatin-induced hepatotoxicity

Kotb,

Alhamdi,

Alfaifi

et al. 2024

International Journal of Biological Macromolecules

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Effect of Datura stramonium on Cyclophosphamide-induced Oxidative Stress in Albino Rats: Study on Kidney Markers

Cited by 5 publications

References 20 publications

Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats

Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats

The protective role of Gallic acid in Cisplatin nephrotoxicity

Examining the quaternary ammonium chitosan Schiff base-ZnO nanocomposite's potential as protective therapy for rats' cisplatin-induced hepatotoxicity

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