Effect of Dawood Fasting on the Increased Level of Antioxidant Enzymes

Abstract

AIM: The aim of this study is to provide a comparative histopathological evaluation of the regeneration of bone defect filling with perforated antibiotic-impregnated bone allograft.
 MATERIALS AND METHODS: Seventy-two healthy rabbits (24 rabbits in each group) were used for this study. Bone defects (3-mm diameter, 10-mm depth) were created in the femur. Human femoral head prepared according to the Marburg bone bank system was used as a bone allograft. The control group did not receive any filling. The experimental groups were as follows: Group 1 – the defects were filled with bone allografts and Group 2 – Perforated gentamycin-impregnated bone allografts. The animals were euthanized after 14, 30, and 60 days. Evaluations consisted of histology at 14-, 30-, and 60-days post-surgery.
 RESULTS: A mature bone formation in the group without a bone allograft occurred after 30 days and the group with an allograft after 14 days. In the groups with an allograft, a bone marrow defect was noted as complete closure after 30 days. Histomorphometric analysis showed that in the group with an antibiotic-impregnated bone, allograft leads to increased resorption of the allograft in the intramedullary space compared to group without antibiotic.
 CONCLUSION: We believe that a perforated allograft as a result of clinical trials may be obvious and economically affordable in the treatment of bone defects. The use of gentamycin-impregnated bone allografts may be of value in the prevention and treatment of bone infections.

Effects of Regular Exercise and Intermittent Fasting on Neurotransmitters, Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Cortex of Ovariectomized Rats

“…Additionally, this result is in line with a prior experiment conducted by Utami Mulyaningrum et al [61], which suggested that Dawood fasting (DF) might be used as a substitute for dietary restriction in order to raise SOD, GPx, and Cat antioxidant enzyme levels. This implies a DF increase in TAC levels.…”

Islamic Fasting Models but not Only Ramadan Improved Metabolic Parameter in High-Fat-High-Fructose-Induced Rats

“…Based on observational studies in humans, Ramadan fasting has improved lipid profiles by reducing triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) [10]. A study by Ma et al [5] in experimental animals reported that intermittent fasting had reduced glucose levels and enhanced hepatic metabolism, in line with other studies in which intermittent fasting reduces systemic oxidative stress and increases antioxidant enzymes in the liver as a central metabolic homeostasis organ [11], [12].…”

The Effects of Dawood Fasting on The Morphology of Intestinal Mucosa in Balb/c Mice

“…Such good bacteria also increase significantly in number after the diabetic mice, the villi were significantly longer than in the AL diet mice (22). Dawood fasting can inhibit cell death due to the increased formation of antioxidants, including superoxide dismutase, glutathione peroxidase and catalase (23). The antioxidants formed during fasting for fewer than 24 hours can prepare the body to cope with oxidative stress during the refeeding phase.…”