Effect of decreased levels of endogenous gastric tissue histamine on acid secretion and stress ulcer formation in the rat.

Ritchie, Wallace P.; Breen, J. J.; Grigg, David; Wangensteen, Owen H.

doi:10.1136/gut.8.1.32

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1969

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Cited by 14 publications

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“…No attempt was made in the present study to elucidate the mechanism by which gastric erosions were produced in mice under restraint and water immersion, however, a number of observations indicate that these erosions in mice resemble those induced by restraint in rats, thus the mechanisms involved could be the same (1,2,7,8 …”

Section: Discussionmentioning

confidence: 80%

A Method for the Production of Stress Erosion in the Mouse Stomach and Related Pharmacological Studies

Yano

Harada

1973

Jpn.J.Pharmacol

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Section: Discussionmentioning

confidence: 80%

A Method for the Production of Stress Erosion in the Mouse Stomach and Related Pharmacological Studies

Yano

Harada

1973

Jpn.J.Pharmacol

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Effects of FPL-52694, a new mast cell stabilizer, on gastric secretion and various acute gastric lesions in rats

et al. 1984

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Oral FPL-52694 [5-(2-hydroxypropoxy)-8-propyl-4-oxo-4H-1-benzopyran-2-carboxylic acid Na], a new mast cell stabilizer, dose-dependently inhibited gastric acid secretion but increased the volume and pepsin output in pylorus-ligated rats. Intraduodenal FPL-52694 significantly inhibited all of the volume, acidity, acid output and pepsin output. Concerning the acidity, oral administration of the agent showed much more potent inhibition than intraduodenal administration. Oral FPL-52694 markedly inhibited the development of pylorus-ligated ulcers, water-immersion stress- and aspirin-induced gastric erosions and moderately inhibited the formation of reserpine-induced gastric erosions in rats. Intraduodenal FPL-52694 also inhibited pylorus-ligated ulcers whereas it had no effect on aspirin-induced gastric erosions. Histamine-induced gastric erosions were not affected by oral FPL-52694. These effects of FPL-52694 were almost the same as those of cimetidine, except that cimetidine tended to inhibit histamine-induced gastric erosions. Although the precise mechanism of action of FPL-52694 remains unknown, oral FPL-52694 appears to be a promising agent for the treatment of peptic ulcers.

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Current concepts of peptic ulceration

Bralow

1969

Digest Dis Sci

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Effect of decreased levels of endogenous gastric tissue histamine on acid secretion and stress ulcer formation in the rat.

Cited by 14 publications

References 14 publications

A Method for the Production of Stress Erosion in the Mouse Stomach and Related Pharmacological Studies

A Method for the Production of Stress Erosion in the Mouse Stomach and Related Pharmacological Studies

Effects of FPL-52694, a new mast cell stabilizer, on gastric secretion and various acute gastric lesions in rats

Current concepts of peptic ulceration

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