Effect of dermal thickness, tissue composition, and body site on skin biomechanical properties

Smalls, Lola K; Wickett, R. Randall; Visscher, Marty O.

doi:10.1111/j.0909-725x.2006.00135.x

Cited by 167 publications

(141 citation statements)

References 29 publications

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“…Suction methods which use a negative pressure to deform the skin (Fig. 4c) are perhaps the most widely used (Diridollou et al 1999;Pierard 1999;Rodrigues 2001;Smalls et al 2006;Takema and Imokawa 1998;Takema et al 1994). Diridollou and co-workers suggest that this technique enables the measurement of mechanical responses which originate primarily from the dermis rather than subcutaneous structures (Diridollou et al 1998).…”

Section: Cutaneousmentioning

confidence: 99%

“…Diridollou and co-workers suggest that this technique enables the measurement of mechanical responses which originate primarily from the dermis rather than subcutaneous structures (Diridollou et al 1998). Commercially developed devices include the Cutometer, which measures skin deformations optically, and the Dermaflex A, which measures vertical skin displacements by changes in capacitance (Diridollou et al 1998;Smalls et al 2006 biomechanical properties measured by these techniques requires quantitation of skin thickness. Early attempts to measure skin thickness using callipers ) have largely been superseded by the use of ultrasound (Diridollou et al 1999;Escoffier et al 1989;Takema et al 1994).…”

Section: Cutaneousmentioning

confidence: 99%

“…Removing the force allows the skin to recover and the ratio of the recovery to initial deformation quantifies the ability of the skin to elastically recoil. Both the ratio of the rapid elastic recovery to the elastic deformation (where U R /U E is defined as the elastic function) and the ratio of the rapid elastic recovery to the total skin deformation (where U R /U F is defined as relative elastic recovery) have been quoted in the literature (Escoffier et al 1989;Rodrigues 2001;Smalls et al 2006). The ability of skin to recoil is significantly reduced by both the intrinsic (Escoffier et al 1989;Smalls et al 2006;Takema et al 1994) and extrinsic ageing processes Smalls et al 2006;Staloff et al 2008;Takema et al 1994) and by exposure to UV-A and UV-B radiation in vitro (Takema and Imokawa 1998).…”

Section: Cutaneousmentioning

confidence: 99%

“…Both the ratio of the rapid elastic recovery to the elastic deformation (where U R /U E is defined as the elastic function) and the ratio of the rapid elastic recovery to the total skin deformation (where U R /U F is defined as relative elastic recovery) have been quoted in the literature (Escoffier et al 1989;Rodrigues 2001;Smalls et al 2006). The ability of skin to recoil is significantly reduced by both the intrinsic (Escoffier et al 1989;Smalls et al 2006;Takema et al 1994) and extrinsic ageing processes Smalls et al 2006;Staloff et al 2008;Takema et al 1994) and by exposure to UV-A and UV-B radiation in vitro (Takema and Imokawa 1998). In most studies, skin stiffness [as determined from a decrease in elastic (U E ) or total deformation (U F )] also increased significantly in both intrinsically (Escoffier et al 1989;Smalls et al 2006) and extrinsically aged tissue Smalls et al 2006;Takema et al 1994) and in UV radiation-exposed tissues (Takema and Imokawa 1998).…”

Section: Cutaneousmentioning

confidence: 99%

“…The ability of skin to recoil is significantly reduced by both the intrinsic (Escoffier et al 1989;Smalls et al 2006;Takema et al 1994) and extrinsic ageing processes Smalls et al 2006;Staloff et al 2008;Takema et al 1994) and by exposure to UV-A and UV-B radiation in vitro (Takema and Imokawa 1998). In most studies, skin stiffness [as determined from a decrease in elastic (U E ) or total deformation (U F )] also increased significantly in both intrinsically (Escoffier et al 1989;Smalls et al 2006) and extrinsically aged tissue Smalls et al 2006;Takema et al 1994) and in UV radiation-exposed tissues (Takema and Imokawa 1998). In contrast to intrinsically aged skin, which is characterised histologically by the loss of elastic fibre components, extrinsically aged skin is characterised by the gain of disorganised elastotic material.…”

Section: Cutaneousmentioning

confidence: 99%

See 4 more Smart Citations

Tissue elasticity and the ageing elastic fibre

Sherratt

2009

AGE

270

189

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The ability of elastic tissues to deform under physiological forces and to subsequently release stored energy to drive passive recoil is vital to the function of many dynamic tissues. Within vertebrates, elastic fibres allow arteries and lungs to expand and contract, thus controlling variations in blood pressure and returning the pulmonary system to a resting state. Elastic fibres are composite structures composed of a cross-linked elastin core and an outer layer of fibrillin microfibrils. These two components perform distinct roles; elastin stores energy and drives passive recoil, whilst fibrillin microfibrils direct elastogenesis, mediate cell signalling, maintain tissue homeostasis via TGFβ sequestration and potentially act to reinforce the elastic fibre. In many tissues reduced elasticity, as a result of compromised elastic fibre function, becomes increasingly prevalent with age and contributes significantly to the burden of human morbidity and mortality. This review considers how the unique molecular structure, tissue distribution and longevity of elastic fibres pre-disposes these abundant extracellular matrix structures to the accumulation of damage in ageing dermal, pulmonary and vascular tissues. As compromised elasticity is a common feature of ageing dynamic tissues, the development of strategies to prevent, limit or reverse this loss of function will play a key role in reducing age-related morbidity and mortality.

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Section: Cutaneousmentioning

confidence: 99%

Section: Cutaneousmentioning

confidence: 99%

Section: Cutaneousmentioning

confidence: 99%

Section: Cutaneousmentioning

confidence: 99%

Section: Cutaneousmentioning

confidence: 99%

See 3 more Smart Citations

Tissue elasticity and the ageing elastic fibre

Sherratt

2009

AGE

270

189

View full text Add to dashboard Cite

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Polylactic Acid Fillers

Beer¹,

Azzawi²,

Beer³

et al. 2022

Cosmetic Dermatology

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Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity

Wang

Duan

Keate

et al. 2023

Adv Healthcare Materials

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Impaired wound healing is a common complication for diabetic patients and effective diabetic wound management remains a clinical challenge. Furthermore, a significant problem that contributes to patient morbidity is the suboptimal quality of healed skin, which often leads to reoccurring chronic skin wounds. Herein, a novel compound and biomaterial building block, panthenol citrate (PC), is developed. It has interesting fluorescence and absorbance properties, and it is shown that PC can be used in soluble form as a wash solution and as a hydrogel dressing to address impaired wound healing in diabetes. PC exhibits antioxidant, antibacterial, anti‐inflammatory, and pro‐angiogenic properties, and promotes keratinocyte and dermal fibroblast migration and proliferation. When applied in a splinted excisional wound diabetic rodent model, PC improves re‐epithelialization, granulation tissue formation, and neovascularization. It also reduces inflammation and oxidative stress in the wound environment. Most importantly, it improves the regenerated tissue quality with enhanced mechanical strength and electrical properties. Therefore, PC could potentially improve wound care management for diabetic patients and play a beneficial role in other tissue regeneration applications.

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Effect of dermal thickness, tissue composition, and body site on skin biomechanical properties

Cited by 167 publications

References 29 publications

Tissue elasticity and the ageing elastic fibre

Tissue elasticity and the ageing elastic fibre

Polylactic Acid Fillers

Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity

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