Effect of detonation nanodiamond surface composition on physiological indicators of mitochondrial functions

Solomatin, A.S.; Yakovlev, R. Yu.; Теплова, В. В.; Федотчева, Н. И.; Kondrachova, Mariya N.; Кулакова, И. И.; Леонидов, Н. Б.

doi:10.1007/s11051-018-4297-0

Cited by 5 publications

(1 citation statement)

References 63 publications

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“…Within the cell the NDs accumulate in lysosomes or form clusters in the cytoplasm. Interaction with other organelles is not yet proved, but influence of NDs on mitochondria must be considered too with respect to possible induction of oxidative stress, apoptosis, pyroptosis, and autophagy. ,− Recently it was published that NDs at noncytotoxic concentrations were able to increase both total NO and ROS production in the A549 and BV-2 cells. The treatment negatively affected concentrations of high-energy phosphates, nicotinic coenzymes, and GSH, indicating an imbalance of energy metabolism and mitochondrial functions and sustained oxidative/nitrosative stress …”

Section: Discussionmentioning

confidence: 99%

Application of Advanced Microscopic Methods to Study the Interaction of Carboxylated Fluorescent Nanodiamonds with Membrane Structures in THP-1 Cells: Activation of Inflammasome NLRP3 as the Result of Lysosome Destabilization

et al. 2019

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Nanodiamonds (ND), especially fluorescent NDs, represent potentially applicable drug and probe carriers for in vitro/in vivo applications. The main purpose of this study was to relate physical–chemical properties of carboxylated NDs to their intracellular distribution and impact on membranes and cell immunityactivation of inflammasome in the in vitro THP-1 cell line model. Dynamic light scattering, nanoparticle tracking analysis, and microscopic methods were used to characterize ND particles and their intracellular distribution. Fluorescent NDs penetrated the cell membranes by both macropinocytosis and mechanical cutting through cell membranes. We proved accumulation of fluorescent NDs in lysosomes. In this case, lysosomes were destabilized and cathepsin B was released into the cytoplasm and triggered pathways leading to activation of inflammasome NLRP3, as detected in THP-1 cells. Activation of inflammasome by NDs represents an important event that could underlie the described toxicological effects in vivo induced by NDs. According to our knowledge, this is the first in vitro study demonstrating direct activation of inflammasome by NDs. These findings are important for understanding the mechanism(s) of action of ND complexes and explain the ambiguity of the existing toxicological data.

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Section: Discussionmentioning

confidence: 99%

Application of Advanced Microscopic Methods to Study the Interaction of Carboxylated Fluorescent Nanodiamonds with Membrane Structures in THP-1 Cells: Activation of Inflammasome NLRP3 as the Result of Lysosome Destabilization

et al. 2019

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Nitrogen Fixation and Biological Behavior of Nanodiamond Colloidal Solutions

et al. 2020

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Detonation‐produced nanodiamond, both as a powder (with adsorbed water) and especially when suspended in an aqueous colloid, can support the growth (both aerobic and anaerobic) of bacteria and fungi. These were isolated and identified by microbiological methods, optical and electron microscopy, as species of Penicillium, Purpureocillium, Beaveria, Trichoderma and Aspergillus genera. The C : N molar ratio of the developing fibers (comprising fungal mycelia with attached bacteria and entrapped nanodiamond) decreased from 25 to 11 between the 1st and 10th week of incubation (cf. 40 in initial nanodiamond, 4.6 typical for bacteria and 8.3 for fungi), and from 4 to <1 after the 12th week, as the lysis of microorganisms releases carbon as CO2 and nitrogen as NH4+ or NO3−. The nitrogen content of the colloid increased by an order of magnitude and more, due to fixation of N2 by nanodiamond under ambient conditions.The process requires water but not necessarily oxygen present.

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An experimental study of sorption/desorption of selected radionuclides on carbon nanomaterials: a quest for possible applications in future nuclear medicine

Kazakov

Garashchenko

Yakovlev

et al. 2020

Diamond and Related Materials

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Effect of detonation nanodiamond surface composition on physiological indicators of mitochondrial functions

Cited by 5 publications

References 63 publications

Application of Advanced Microscopic Methods to Study the Interaction of Carboxylated Fluorescent Nanodiamonds with Membrane Structures in THP-1 Cells: Activation of Inflammasome NLRP3 as the Result of Lysosome Destabilization

Application of Advanced Microscopic Methods to Study the Interaction of Carboxylated Fluorescent Nanodiamonds with Membrane Structures in THP-1 Cells: Activation of Inflammasome NLRP3 as the Result of Lysosome Destabilization

Nitrogen Fixation and Biological Behavior of Nanodiamond Colloidal Solutions

An experimental study of sorption/desorption of selected radionuclides on carbon nanomaterials: a quest for possible applications in future nuclear medicine

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