Effect of Diet-Induced Vitamin D Deficiency on Rotator Cuff Healing in a Rat Model

Angeline, Michael E.; Ma, Richard; Pascual‐Garrido, Cecilia; Voigt, Clifford; Deng, Xiang; Warren, Russell F.; Rodeo, Scott A.

doi:10.1177/0363546513505421

Cited by 84 publications

(70 citation statements)

References 40 publications

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“…First, this was an in vivo study that lacked an in vitro evaluation of the potential impact of ICA. Thus, the mechanism of angiogenesis enhancement by ICA was not studied, which may decrease the robustness of our results; Second, we evaluated the effects of ICA on the early stage of tendon-bone healing during repair of RCT (at two and four weeks), but the longer-term effects of ICA were not evaluated; Third, we used a well-established RC reconstruction model, as described previously [43,67,68,69,70], which differs from that used in humans. The single load-to-failure test construct in this study might not be identical to cases of RCT; Fourth, although we evaluated the effect of ICA on osteogenic markers, including AP, and OCN, the role of ICA therapy on calcium homeostasis and its mechanism, however, is not studied.…”

Section: Discussionmentioning

confidence: 99%

Icariin Promotes Tendon-Bone Healing during Repair of Rotator Cuff Tears: A Biomechanical and Histological Study

Zhang

Wang

et al. 2016

IJMS

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To investigate whether the systematic administration of icariin (ICA) promotes tendon-bone healing after rotator cuff reconstruction in vivo, a total of 64 male Sprague Dawley rats were used in a rotator cuff injury model and underwent rotator cuff reconstruction (bone tunnel suture fixation). Rats from the ICA group (n = 32) were gavage-fed daily with ICA at 0.125 mg/g, while rats in the control group (n = 32) received saline only. Micro-computed tomography, biomechanical tests, serum ELISA (calcium; Ca, alkaline phosphatase; AP, osteocalcin; OCN) and histological examinations (Safranin O and Fast Green staining, type I, II and III collagen (Col1, Col2, and Col3), CD31, and vascular endothelial growth factor (VEGF)) were analyzed two and four weeks after surgery. In the ICA group, the serum levels of AP and OCN were higher than in the control group. More Col1-, Col2-, CD31-, and VEGF-positive cells, together with a greater degree of osteogenesis, were detected in the ICA group compared with the control group. During mechanical testing, the ICA group showed a significantly higher ultimate failure load than the control group at both two and four weeks. Our results indicate that the systematic administration of ICA could promote angiogenesis and tendon-bone healing after rotator cuff reconstruction, with superior mechanical strength compared with the controls. Treatment for rotator cuff injury using systematically-administered ICA could be a promising strategy.

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Section: Discussionmentioning

confidence: 99%

Icariin Promotes Tendon-Bone Healing during Repair of Rotator Cuff Tears: A Biomechanical and Histological Study

Zhang

Wang

et al. 2016

IJMS

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“…11,22,[26][27][28][29] In brief, the athymic rats were anesthetized with 2% isoflurane in high-flow oxygen. They were shaved and positioned supine on a specially designed procedure table.…”

Section: Surgical Techniquementioning

confidence: 99%

The Effect of Purified Human Bone Marrow–Derived Mesenchymal Stem Cells on Rotator Cuff Tendon Healing in an Athymic Rat

Degen

Carbone

Carballo

et al. 2016

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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“…Chung et al [14] , in a study of 272 patients after arthroscopic rotator cuff repair, found that bone mineral density was an independent predictors of rotator cuff healing. In a rat rotator cuff repair model, Angeline et al [37] demonstrated that vitamin D deficiency negatively affects the biomechanical and histological properties of rotator cuff repairs during the early phase of healing. This effect was found to be independent of bone mineral density [37] .…”

Section: Muscle-tendon Unit Retractionmentioning

confidence: 99%

“…In a rat rotator cuff repair model, Angeline et al [37] demonstrated that vitamin D deficiency negatively affects the biomechanical and histological properties of rotator cuff repairs during the early phase of healing. This effect was found to be independent of bone mineral density [37] . Other system diseases have been associated with rotator cuff tearing as well as rotator cuff healing.…”

Section: Muscle-tendon Unit Retractionmentioning

confidence: 99%

Factors affecting healing after arthroscopic rotator cuff repair

Abtahi

Granger

Tashjian

2015

WJO

162

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Rotator cuff repair has been shown to have good longterm results. Unfortunately, a significant proportion of repairs still fail to heal. Many factors, both patient and surgeon related, can influence healing after repair. Older age, larger tear size, worse muscle quality, greater muscle-tendon unit retraction, smoking, osteoporosis, diabetes and hypercholesterolemia have all shown to negatively influence tendon healing. Surgeon related factors that can influence healing include repair construct-single vs double row, rehabilitation, and biologics including platelet rich plasma and mesenchymal stem cells. Double-row repairs are biomechanically stronger and have better healing rates compared with single-row repairs although clinical outcomes are equivalent between both constructs. Slower, less aggressive rehabilitation programs have demonstrated improved healing with no negative effect on final range of motion and are therefore recommended after repair of most full thickness tears. Additionally no definitive evidence supports the use of platelet rich plasma or mesenchymal stem cells regarding improvement of healing rates and clinical outcomes. Further research is needed to identify effective biologically directed augmentations that will improve healing rates and clinical outcomes after rotator cuff repair. Core tip: Many factors, both patient and surgeon related, can influence healing after repair. Older age, larger tear size, worse muscle quality, greater muscletendon unit retraction, smoking, osteoporosis, diabetes and hypercholesterolemia have all shown to negatively influence tendon healing after rotator cuff repair. Smoking cessation and blood glucose and cholesterol control are methods to potentially improve healing rates. Slower, less aggressive rehabilitation programs may improve healing rates with no negative effect on final range of motion and are therefore recommended after arthroscopic repair of most full thickness tears. Finally, no definitive evidence supports the use of platelet rich plasma or mesenchymal stem cells regarding improvement of healing rates after rotator cuff repair. Routine use of these adjuvants is therefore not currently recommended.

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Effect of Diet-Induced Vitamin D Deficiency on Rotator Cuff Healing in a Rat Model

Cited by 84 publications

References 40 publications

Icariin Promotes Tendon-Bone Healing during Repair of Rotator Cuff Tears: A Biomechanical and Histological Study

Icariin Promotes Tendon-Bone Healing during Repair of Rotator Cuff Tears: A Biomechanical and Histological Study

The Effect of Purified Human Bone Marrow–Derived Mesenchymal Stem Cells on Rotator Cuff Tendon Healing in an Athymic Rat

Factors affecting healing after arthroscopic rotator cuff repair

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