Effect of Dietary Fat Level and Sesamin on the Polyunsaturated Fatty Acid Metabolism in Rats

Mizukuchi, Aya; Umeda-Sawada, Rumi; Igarashi, Osamu

doi:10.3177/jnsv.49.320

Cited by 18 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sprague-Dawley rats were fed each of the experimental diets for 4 weeks and 4 days by a 3-hour feeding protocol. For abbreviations see Tables 1 and 2. comparable to high fat (ϳ40% of total energy from fat) and low fat (ϳ10% of total energy from fat) [35,36]. Thus, we used 1C diet with minimum essential fatty acids as a control, and selected 10% (w/w, estimated 20% calories), as the moderate fat intake level to compare the inhibitory effect of dietary fats on lipogenesis.…”

Section: Discussionmentioning

confidence: 99%

Suppression of hepatic fatty acid synthase by feeding α-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats

Kim

Choi

2004

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Suppression of hepatic fatty acid synthase by feeding α-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats

Kim

Choi

2004

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

“…Sesamin is a known lipid modulator well investigated in mammalian systems [1][2][3]. To our knowledge it has never been investigated in fish.…”

Section: Introductionmentioning

confidence: 99%

“…Sesamin inhibits cholesterol absorption and synthesis, and tocopherol hydroxylation and urinary excretion by Cytochrome P450 in rats and humans [1,[13][14][15]. The methylenedioxyphenyl group of sesamin is known to affect cytochrome P450-dependent drug oxidation [16].…”

Section: Introductionmentioning

confidence: 99%

Sesamin Supplementation Increases White Muscle Docosahexaenoic Acid (DHA) Levels in Rainbow Trout (Oncorhynchus mykiss) Fed High Alpha‐Linolenic Acid (ALA) Containing Vegetable Oil: Metabolic Actions

Trattner

Kamal‐Eldin

Brännäs

et al. 2008

Lipids

View full text Add to dashboard Cite

The effects of including an equi-mixture of sesamin and episesamin in fish diets based on vegetable oils of different fatty acid composition were examined. Sesamin/episesamin (hereafter named sesamin) was included at 0.58 g/100 g diet. The oil used in the feed was either a mixture of linseed and sunflower oils (6:4, by vol) or 100% linseed oil. Addition of sesamin increased the percentages of docosahexaenoic acid (DHA) in white muscle phospholipid and triacylglycerol fraction by up to 37% but the fatty acids in red muscle and liver were not affected. The expression of the peroxisome proliferator-activated receptor PPARalpha was significantly down regulated in the liver of the fish fed sesamin and mixed oil diet (P < 0.05). Sesamin and episesamin were detected in liver and muscle tissues of the fish that had been fed sesamin. Fish fed sesamin had elevated levels of total cytochrome P450 (CYP) enzymes and EROD activity in the liver, indicating an induction of CYP1A in this tissue. Our conclusion was that supplementation of fish feed with sesamin increased the proportions of DHA in the white muscle.

show abstract

“…Sesamin is a natural lignan present in sesame seeds and oil in relatively high amounts (Moazzami & Kamal‐Eldin ). The properties of sesamin as a lipid modulator have been investigated positively (increased of PUFA concentration) in mammalian systems, specifically in rats (Mizukuchi, Umeda‐Sawada & Igarashi ; Ide, Hong, Ranasinghe, Takahashi, Kushiro & Sugano ) and in human lipid metabolism (Jeng & Hou ). The use of sesamin as a modulator of LC‐PUFA composition in fish was tested successfully on rainbow trout ( Oncorhynchus mykiss ) (Trattner, Kamal‐Eldin, Brannas, Moazzami, Zlabek, Larsson, Ruyter, Gjoen & Pickova ; Vestergren, Trattner, Pan, Johnsson, Kamal‐Eldin, Brännäs, Moazzami & Pickova ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of dietary sesamin on white muscle lipid composition of common carp (Cyprinus carpioL.) juveniles

2015

View full text Add to dashboard Cite

This study was focused on the clarification of the effect of dietary sesamin on fatty acids and the composition of different lipid fractions [phospholipids (PLs), cholesterol and triacylglycerols] in the white muscle of common carp (Cyprinus carpio L.) juveniles. Two different basic diets with defatted fishmeal as a protein source and either only linseed oil or a mixture of linseed and sunflower oil as a lipid source designed to have two different n‐3/n‐6 ratios (1.21 – CL group; 0.32 – CM group) were produced. Each diet was then used with or without added sesamin (0.58 g 100g−1). One hundred and forty‐four individuals were fed in triplicated groups for 63 days until their weight had doubled. No influence of dietary sesamin on growth, mortality or on the white muscle lipid content of the fish was found. Added sesamin significantly decreased the content of PLs and increased the cholesterol content in the CM group. No effect was found in the total lipid fatty acid composition but there was found a significantly lower content of saturated fatty acids and 20:5n‐3 in PLs and of 22:6n‐3 in triacylglycerols in the sesamin supplemented CL group. These and other differences show either a tendency of lower long chain n‐3 fatty acids biosynthesis or their higher use in β‐oxidation in sesamin‐supplemented groups. We conclude that sesamin in this experiment had no substantial positive impact on the lipid metabolism of juvenile carp.

show abstract

Effect of Dietary Fat Level and Sesamin on the Polyunsaturated Fatty Acid Metabolism in Rats

Cited by 18 publications

References 22 publications

Suppression of hepatic fatty acid synthase by feeding α-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats

Suppression of hepatic fatty acid synthase by feeding α-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats

Sesamin Supplementation Increases White Muscle Docosahexaenoic Acid (DHA) Levels in Rainbow Trout (Oncorhynchus mykiss) Fed High Alpha‐Linolenic Acid (ALA) Containing Vegetable Oil: Metabolic Actions

Evaluation of the effect of dietary sesamin on white muscle lipid composition of common carp (Cyprinus carpioL.) juveniles

Contact Info

Product

Resources

About