Effect of dietary supplementation of binahong leaf meal, betel nut meal or their combination on serum albumin and globulin, fecal endoparasites and bacterial counts in milk of Saanen goats suffering from subclinical mastitis

Patients with diabetes are 1.6 times more likely to use complementary alternative medicine than nondiabetic patients. Previous studies have shown that Anredera cordifolia (Tenore) Steen. (A. cordifolia) leaf extract has the capacity to lower blood glucose, but the actual mechanisms are unclear. Therefore, in this study, we explored the effect of A. cordifolia leaf extract on the metabolism of fatty acids and amino acids. Six-week-old male Wistar rats were randomly divided into six experimental groups (n = 5 per group). Two groups were fed with a regular diet or a high-fat diet (HFD) for six weeks. The regular diet and HFD groups were administered with 0.5% carboxymethylcellulose as a vehicle, and HFD rats were also fed with a suspension of glibenclamide (0.51 mg/kg body weight (BW)) or A. cordifolia leaf extract (25, 50, and 100 mg/kg BW). During the whole treatment, BW and food intake were recorded weekly. The rats were euthanized seven weeks after treatment. Blood glucose was evaluated by spectrophotometry, while fatty acids and amino acids were evaluated using a gas chromatography/flame ionization detector (GC/FID). All doses of A. cordifolia administration reduced blood glucose significantly, and 50 mg/kg BW was most effective in lowering blood glucose, similar to the effects of glibenclamide. A. cordifolia leaf extract affected the levels of medium-chain fatty acids, especially at 50 mg/kg BW. In contrast, glibenclamide affected long-chain fatty acids (LCFAs) to lower blood glucose. Based on the analysis conducted, we conclude that administration of A. cordifolia leaf extract can decrease blood glucose levels by regulating fatty acid metabolism and that a dose of 50 mg/kg BW in rats was the optimal dose.

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“…During the treatment, BW and food intake were recorded weekly. The rats were euthanized seven weeks after the beginning of the treatment [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…Some native tribes in Indonesia use the leaves of the A. cordifolia ( Anredera cordifolia (Tenore) Steen.) plant to empirically reduce blood sugar, even as vegetables [ 8 ]. Other studies report that A. cordifolia leaf extract can inhibit α -glucosidase with an IC 50 value of 54.24 μ g/ml.…”

Section: Introductionmentioning

confidence: 99%

Binahong (Anredera cordifolia (Tenore) Steen.) Leaf Extract Modulates Fatty Acids and Amino Acids to Lower Blood Glucose in High-Fat Diet-Induced Diabetes Mellitus Rats

Dwitiyanti

Harahap

Elya

et al. 2021

Advances in Pharmacological and Pharmaceutical Sciences

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“…AC leaves are traditionally used in Indonesia to reduce blood glucose. 78,79 The AC leaf extract has been shown to reduce blood glucose levels in rats with high-fat diet-induced diabetes mellitus by regulating fatty acid metabolism. 78,79 To our knowledge, no data have been published concerning the effects of AC intake on serum glucose levels in healthy elderly individuals.…”

Section: Food and Function Papermentioning

confidence: 99%

“…78,79 The AC leaf extract has been shown to reduce blood glucose levels in rats with high-fat diet-induced diabetes mellitus by regulating fatty acid metabolism. 78,79 To our knowledge, no data have been published concerning the effects of AC intake on serum glucose levels in healthy elderly individuals. In this study, we observed significantly reduced serum glucose levels in association with increased RBC-PM ALA levels in both the PO and POAC groups after 12 months of treatment.…”

Section: Food and Function Papermentioning

confidence: 99%

Perilla frutescens seed oil combined with Anredera cordifolia leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: a possible supplement for brain health

et al. 2022

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“…Tumbuhan yang dapat ditemui di alam bebas di hutan tropis Indonesia banyak dilaporkan mengandung senyawa aktif seperti antioksidan, antitoksik, bahan penyembuh luka, dan aktivitas lainnya. 1,2 Dalam beberapa dekade ini, penelitian mengenai pengembangan proses isolasi senyawa penyembuh luka mulai marak dikembangkan. 3 Salah satu tumbuhan khas yang terdapat di hutan tropis Indonesia adalah hasil ekstraksi daun Binahong atau yang memiliki nama latin (Anredera cordifolia (Ten) Steenis).…”

Section: Pendahuluanunclassified

Isolation and Characterization of Wound Healing Compounds from Chloroform Extract of Binahong Leaves (Anredera cordifolia (Ten.) Steenis)

Rohani

Purwoko

2021

magnamed

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The leaves of Binahong (Anredera cordifolia (Ten) Steenis) have been widely studied to have benefits and uses in various medical purposes, one of which is in the wound healing process. The existence of several active compounds contained in the leaves of the Binahong tree plant have an important role in wound healing, such as flavonoids, terpenoids, alkaloids, saponins, ascorbic acid and citrate compounds, these compounds are the targeted for further process of this natural product. The eminence of the extraction method that is used repeatedly and consistently to obtain pure compounds from Binahong leaves to be isolated is the one of topics discussed in this literature study. The perspective of implementation from liquid-solid extraction followed by liquid-liquid extraction using chloroform as a solvent is discussed comprehensively in this article. The identification of the isolation of compounds are able to conducted by implemented a thin layer chromatography (TLC) techniques, and for the further structural determination by UV, MS, FTIR, NMR spectroscopy and separation techniques using GC-MS. Respectively, the components are successfully to be identified and reported in previous research, for the following criteria that have been completed, some isolated active compound are purposed as the candidate for the wound healing agent. For the further application it is reasonable to implied these matters for some pharmaceutical products.

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Effect of dietary supplementation of binahong leaf meal, betel nut meal or their combination on serum albumin and globulin, fecal endoparasites and bacterial counts in milk of Saanen goats suffering from subclinical mastitis

Cited by 5 publications

References 17 publications

Binahong (Anredera cordifolia (Tenore) Steen.) Leaf Extract Modulates Fatty Acids and Amino Acids to Lower Blood Glucose in High-Fat Diet-Induced Diabetes Mellitus Rats

Binahong (Anredera cordifolia (Tenore) Steen.) Leaf Extract Modulates Fatty Acids and Amino Acids to Lower Blood Glucose in High-Fat Diet-Induced Diabetes Mellitus Rats

Perilla frutescens seed oil combined with Anredera cordifolia leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: a possible supplement for brain health

Isolation and Characterization of Wound Healing Compounds from Chloroform Extract of Binahong Leaves (Anredera cordifolia (Ten.) Steenis)

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