Effect of Diets Containing Varying Concentrations of Essential Fatty Acids and Triglycerides on Renal Function in Uremic Rats and NZB/NZW F₁ Mice

Abstract

Influences of essential fatty acids (EFA) and triglycerides as reasons for the progression of chronic renal failure are still in debate. We studied the outcome of four diets containing different concentrations of triglycerides and EFA in ⁵/₆ nephrectomized rats and in NZB/W mice up to 45 weeks. The results showed no significant differences in the outcome of survival rate, proteinuria, urea, and creatinine levels as well as histological findings in the different groups of both animal models. We conclude that diets containing EFA up to C_18:2 or being free of EFA or that triglyceride-enriched diets have no influence on the natural course of the renal disease in these both experimental models.

Effect of Eicosapentaenoic Acid Rich Menhaden Oil and MaxEPA on the Autoimmune Disease of Mrl/l Mice

“…The amount of lipid added in our experiment was maximally 25%, while Kelley and Izui [8] gave 50% lipid which may explain the difference in results. Hirschberg et al [22], who also used less than 25% lipid in their experiments, found no influence on the renal histology in NZB/W from the total amount of lipids or of esterified fatty acids.…”

Effect of dietary linoleic acid on the progression of chronic renal failure in rats

“…Many studies have compared these two sources of prostaglandins (those from dienoic series with those of trienoic series) but with inconclusive results (5-7). Studies using different experimental models such as a 5/6 reduction of renal mass, lupus nephritis, and immunologic glomerulonephritis have suggested that increases in vasodilatory prostaglandins could retard the progression of CRF (8)(9)(10).…”