Effect of Difructose Anhydride III on Calcium Absorption in Humans

Shigematsu, Norihiro; Okuhara, Yasuhide; Shiomi, Takuya; Tomita, Fusao; Hara, Hiroshi

doi:10.1271/bbb.68.1011

Cited by 46 publications

(26 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That is, the rank order of the absolute bioavailability of calcium from the three calcium salts is consistent with the rank of the calcium absorbability determined by Tsugawa et al 28) and Cai et al 20) . This may be explained by the fact that calcium may form a soluble calcium complex with ascorbate, which may prolong its transit time through the small intestine.…”

Section: Discussionsupporting

confidence: 87%

“…However, no one has examined absolute calcium bioavailability using modern pharmacokinetics, even though Yergey et al 19) indicated theoretically that the fractional absorption using dual-isotope approaches are closely related to the concept of absolute bioavailability defined from pharmacokinetics. 22,23) To examine different calcium supplements, the absorbability of various calcium salts has been studied, and results indicated that food or its elements, like lactose, can enhance calcium absorption via a paracellular route in the intestine, [26][27][28] but what causes the different degrees of absorption between the calcium salts is a topic of discussion. Several studies have suggested that solubility plays a crucial role in intestinal absorption, [29][30][31] but others have suggested that solubility has little or no correlation with bioavailability.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacokinetic Characterization of Calcium from Three Calcium Salts (Calcium Chloride, Calcium Acetate and Calcium Ascorbate) in Mice

Ueda

Taira

2012

J. Hard Tissue Biology.

View full text Add to dashboard Cite

Calcium is an essential mineral, and its deficiency causes several diseases such as osteoporosis. The absolute bioavailability of calcium using modern pharmacokinetic methods has not been determined even though the relative bioavailability of calcium from various calcium salts has been examined using classic kinetics and pharmacokinetics. The serum calcium concentrations of three calcium salts, calcium chloride, calcium acetate and calcium ascorbate, were measured at various times after intravenous (i.v.) and oral administrations in mice, and the pharmacokinetic behaviors of the salts were investigated using a noncompartmental model. The degree of dissociation of the calcium salts was determined based on the extent of freezing-point depression. The pharmacokinetic parameters, MRT, Vdss, CLtot and AUC for i.v. administration of calcium at 15 and 30 mg/kg from three calcium salts indicated that all three may undergo similar mechanisms of calcium metabolism. The pharmacokinetic process was linear due to a first-order reaction. The pharmacokinetic parameters of calcium after oral administration at 150 mg/kg indicated that the calcium absorption was significantly different among the three calcium salts. The absolute calcium bioavailability of calcium ascorbate and calcium acetate was 2.6 and 1.5-fold, respectively, greater than that of calcium chloride. The mean residence time, MRTab, for absorption of calcium from calcium ascorbate was longer than those from calcium chloride and calcium acetate. Furthermore, it was estimated that calcium absorbed by passing through the intestinal membrane was the dissociated form because of higher degrees of apparent dissociation for the three salts. The calcium absorbability from calcium ascorbate via the intestinal track is significantly higher than those of calcium chloride and calcium acetate.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Characterization of Calcium from Three Calcium Salts (Calcium Chloride, Calcium Acetate and Calcium Ascorbate) in Mice

Ueda

Taira

2012

J. Hard Tissue Biology.

View full text Add to dashboard Cite

show abstract

“…Oral administration of NOD enhances intestinal calcium absorption in humans; this effect has been observed after a single dose of difructose anhydride III (DFA III) in healthy young men ( 10 ) and after the administration of either 9 wk of transgalactooligosaccharides ( 11 ) or 9 d of oligofructose in adolescents ( 12 ). Several hypotheses have been advanced to explain the potential positive effect of NOD on intestinal mineral absorption in animals.…”

mentioning

confidence: 99%

Long-Term Administration of 4G-.BETA.-D-Galactosylsucrose (Lactosucrose) Enhances Intestinal Calcium Absorption in Young Women: A Randomized, Placebo-Controlled 96-wk Study

Teramoto

Rokutan

Sugano

et al. 2006

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryThis study determined the effect of long-term administration of 4 G -␤ -D -galactosylsucrose (lactosucrose; LS) on intestinal calcium absorption. In a randomized, singleblind, parallel-group study, LS ( n ϭ 9, 6.0 g twice daily) or a placebo (maltose; n ϭ 8, 6.0 g twice daily) was administered to healthy young women for 92 wk; the study also included a 4-wk post-administration period. All participants completed the study. Dietary nutrient intake; fecal weight, pH, and moisture content; fecal concentrations of short-chain fatty acids (SCFA), putrefactive products, ammonia, and minerals (calcium, magnesium, phosphorus, and iron); and serum calcium and osteocalcin concentrations were measured every 24 wk. Urinary pyridinoline (PYR) and deoxypyridinoline (DPD), and urinary calcium excretion were measured every 12 wk. Significant effects of oligosaccharide treatment, time, and the interaction between oligosaccharide treatment and time were observed for fecal pH, SCFA, ammonia, and putrefactive product values ( p Ͻ 0.05). Fecal pH, ammonia, and putrefactive product values decreased in the LS group, and the fecal SCFA concentration significantly increased during the administration period; these changes were not observed 4 wk post-administration. To examine the mineral balance of calcium, magnesium, and phosphorus in detail, all the participants completed a 6-d mineral balance study, sometime between week 56 and 60 of the longer study. During the mineral balance study, the daily calcium intake was set at 400 mg; all feces and urine were collected each day for 6 d after an 8-d acclimation period. In the balance study, fecal calcium excretion was significantly lower in the LS group than in the placebo group ( p Ͻ 0.05), and apparent calcium absorption and retention, apparent magnesium and phosphorus absorption, and magnesium retention were significantly higher in the LS group than in the placebo group ( p Ͻ 0.05). Our results suggest that the administration of LS produces a long-term enhancement of intestinal calcium absorption in healthy young women with lower than recommended calcium intakes. Key Words fecal pH, fecal short-chain fatty acids, intestinal calcium absorption, lactosucrose, young healthy women Calcium is an essential component of bone, and insufficient calcium intake may cause weakened bones, especially in women who are prone to osteoporosis. Bone mass in later life depends on the peak bone mass (PBM) achieved during growth and the rate of subsequent age-related bone loss ( 1 ). Bone mineral is laid down throughout childhood, with the most rapid increase occurring during puberty. The deposition continues, though at a slower rate, after growth in height has stopped ( 2 ). PBM is achieved in early adult life (20-35 y of age), although the exact timing is not certain and may vary in different parts of the skeleton ( 3 ). The calcium intake in young Japanese women is lower than the recommended calcium intake ( 4 -6 ). Thus, these women are at risk of future osteoporosis resulting from insufficient calciu...

show abstract

“…The promoting effect of DFAIII on calcium absorption has been demonstrated by in vivo balance studies and human urinary calcium excretion [15] and balance studies. Compared to the information on calcium absorption, there is no information about DFAIII's effect on zinc absorption from in vivo and human studies.…”

Section: Introductionmentioning

confidence: 98%

Difructose Anhydride III Enhances Zinc Absorption in vivo: Zinc Gluconate is More Suitable for the Effects of Difructose Anhydride III than Zinc Yeast

Hachiya

Okuhara

Raneva

et al. 2006

J. Clin. Biochem. Nutr.

Self Cite

View full text Add to dashboard Cite

Summary We examined the effect of difructose anhydride III (DFAIII) on zinc absorption in rats in two experiments. First, we compared the absorption of zinc from zinc gluconate and zinc yeast with or without DFAIII by measuring concentrations in plasma collected from the portal vein after a single oral administration of zinc gluconate or zinc yeast with or without DFAIII. The peak plasma zinc concentration and the incremental area under the curve (IAUC) of plasma zinc 6 h after administration were highest in the zinc gluconate with DFAIII group. Second, we examined the effect of DFAIII on the absorption of zinc with phytic acid. with or without DFAIII. Plasma zinc levels in groups both with and without DFAIII were nearly the same as those at the baseline. Our results showed that DFAIII was better with zinc gluconate than zinc yeast for zinc absorption, and that DFAIII does not alter the inhibitory effects of phytic acid on zinc absorption.

show abstract

Effect of Difructose Anhydride III on Calcium Absorption in Humans

Cited by 46 publications

References 17 publications

Pharmacokinetic Characterization of Calcium from Three Calcium Salts (Calcium Chloride, Calcium Acetate and Calcium Ascorbate) in Mice

Pharmacokinetic Characterization of Calcium from Three Calcium Salts (Calcium Chloride, Calcium Acetate and Calcium Ascorbate) in Mice

Long-Term Administration of 4G-.BETA.-D-Galactosylsucrose (Lactosucrose) Enhances Intestinal Calcium Absorption in Young Women: A Randomized, Placebo-Controlled 96-wk Study

Difructose Anhydride III Enhances Zinc Absorption in vivo: Zinc Gluconate is More Suitable for the Effects of Difructose Anhydride III than Zinc Yeast

Contact Info

Product

Resources

About