Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets

Zidani, Sofiane; Benakmoum, Amar; Ammouche, A.; Benali, Yasmine; Bouhadef, A.; Abbeddou, Souheila

doi:10.1016/j.jnutbio.2016.11.001

Cited by 26 publications

(30 citation statements)

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“…Based on the potent antioxidant and lipid-lowering properties of lycopene, different studies have assessed it as a beneficial nutrient for the prevention and treatment of MetS. Animal and human-based studies have shown that lycopene reduces blood pressure [ 210 , 211 ], atherosclerotic burden [ 248 ] and improves blood antioxidant capacity [ 246 , 249 ], has an anti-obesity role [ 212 , 213 ], improves insulin sensitivity, reduces hyperglycemia [ 216 , 217 ], and improves the lipid profile [ 214 , 215 ]. Moreover, a retrospective study with 2500 patients with MetS showed that higher serum levels of lycopene are associated with a reduced risk of death [ 250 ].…”

Section: Nutrients (Well-being Through Feeding)mentioning

confidence: 99%

Nutrition, Bioenergetics, and Metabolic Syndrome

et al. 2020

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According to the World Health Organization (WHO), the global nutrition report shows that whilst part of the world’s population starves, the other part suffers from obesity and associated complications. A balanced diet counterparts these extreme conditions with the proper proportion, composition, quantity, and presence of macronutrients, micronutrients, and bioactive compounds. However, little is known on the way these components exert any influence on our health. These nutrients aiming to feed our bodies, our tissues, and our cells, first need to reach mitochondria, where they are decomposed into CO2 and H2O to obtain energy. Mitochondria are the powerhouse of the cell and mainly responsible for nutrients metabolism, but they are also the main source of oxidative stress and cell death by apoptosis. Unappropriated nutrients may support mitochondrial to become the Trojan horse in the cell. This review aims to provide an approach to the role that some nutrients exert on mitochondria as a major contributor to high prevalent Western conditions including metabolic syndrome (MetS), a constellation of pathologic conditions which promotes type II diabetes and cardiovascular risk. Clinical and experimental data extracted from in vitro animal and cell models further demonstrated in patients, support the idea that a balanced diet, in a healthy lifestyle context, promotes proper bioenergetic and mitochondrial function, becoming the best medicine to prevent the onset and progression of MetS. Any advance in the prevention and management of these prevalent complications help to face these challenging global health problems, by ameliorating the quality of life of patients and reducing the associated sociosanitary burden.

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Section: Nutrients (Well-being Through Feeding)mentioning

confidence: 99%

Nutrition, Bioenergetics, and Metabolic Syndrome

et al. 2020

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“…A clinical study has indicated an important effect in serum glucose and insulin control from the consumption of jabuticaba peel, associating such results with the values of fibres and bioactive compounds present in this residue (Plaza et al, 2016). However, another study involving obese animals attributed to a higher glucose tolerance only for phenolic compounds present in tomato peel (Zidani et al, 2017). Thus, GF consumption due to the presence of bioactive compounds and its high fibre content may have contributed to improving serum biochemical parameters as well as other fruit residues.…”

Section: Discussionmentioning

confidence: 99%

Campomanesia sp. flour attenuates non‐alcoholic fatty liver disease on rats fed with a hypercaloric diet

Filho

Santos

Reis

et al. 2020

Animal Physiology Nutrition

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Non‐alcoholic fatty liver disease (NAFLD) is a metabolic disorder caused by excess consumption of hypercaloric foods. Guavira (Campomanesia sp.) pulp has broad technological applicability, yet the peel and seeds are considered industrial residue. The objective of this unprecedented study was to evaluate the effects of the flour from guavira's industrial residue (GF) consumption in rats fed with hypercaloric diet (HD). During 65 days, 50 rats were separated into a control group: 1%, 2%, 4% and 8% HD with GF complementation in the diet. The GF chemical composition, phenolic compounds, antioxidant capacity, serum biochemical parameters (glucose, cholesterol, HDL, non‐HDL, triglycerides, AST, ALT, and oral glucose tolerance test), fat liver content, and hepatic histomorphology had been characterized. GF is mainly composed of fibres, with phenolic content of 7,391.09 mg AGE/100 g GF and relevant antioxidant capacity (IC50 2.22 and ORAC 155.68 μmol/TE g−1). Serum biochemical analysis did not differ statistically (except ALT reduction, p < .05). Fat liver content was smaller on HD2%GF (p < .0001). The control group and 1% GF showed greater diffuse microvesicular steatosis compared to the other groups when using hepatic morphological analysis (p < .05). GF consumption attenuated NAFLD caused by a hypercaloric diet, and this effect may be related to the fibre content and bioactive compounds in GF.

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“…Recent studies have shown that antioxidants exhibit protective effects against the development of diabetes [36]. A few previous studies have assessed the effects of lycopene on BG levels, lycopene supplementation or lycopene-containing foods appear to exhibit beneficial effects on insulin resistance or BG levels in experimental type 2 diabetes model [10, 37, 38]. However, direct evidence with respect to the beneficial effects of lycopene on BG levels is still lacking; moreover, the epidemiologic studies on the association between lycopene or lycopene-containing foods and T2DM are scarce.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic effects of esculeoside A are mediated via activation of AMPK and upregulation of IRS-1

Yang

Zhang

Liu

et al. 2019

BMC Complement Altern Med

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Background Tomato fruit ( Lycopersicon esculentum Mill.) has been suggested to be useful for the prevention of diabetes. Esculeoside A is the main saponin compounds in tomatoes. This study investigated the hypoglycemic effects and the underlying mechanism of esculeoside A in C57BLKS/Leprdb ( db/db ) mice. Methods Wild-type C57BLKS ( db/dm ) mice were used in the db/dm mouse group and db/db mice were randomly divided into 2 groups: untreated and treated db/db mouse groups. Esculeoside A (100 mg/kg) was administered by gavage for 56 days to the treated db/db mouse group. Distilled water was administered to the db/dm mouse group and the untreated db/db mouse group. The blood and liver biochemical parameters and the expression of liver insulin signaling-related proteins were examined. Results The results showed that esculeoside A reduced the fasting blood glucose (FBG) levels and improved the glucose tolerance. Further investigation revealed that hepatic protein expressions of total AMP-activated protein kinase (T-AMPK), phosphorylated AMP-activated protein kinase (p-AMPK), insulin receptor substrate-1 (IRS-1), and glucokinase (GCK) were significantly upregulated after esculeoside A treatment. In contrast, the hepatic protein expression of phosphoenolpyruvate carboxykinase (PEPCK) was significantly downregulated by esculeoside A treatment. Conclusion These findings suggested that esculeoside A has a potential of alleviating the metabolic abnormalities in db/db mice via regulation of AMPK/IRS-1 pathway. Our findings supported a possible application of esculeoside A as a functional supplement for diabetes treatment.

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Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets

Cited by 26 publications

References 50 publications

Nutrition, Bioenergetics, and Metabolic Syndrome

Nutrition, Bioenergetics, and Metabolic Syndrome

Campomanesia sp. flour attenuates non‐alcoholic fatty liver disease on rats fed with a hypercaloric diet

Hypoglycemic effects of esculeoside A are mediated via activation of AMPK and upregulation of IRS-1

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