Effect of Edaravone on Streptomycin‐Induced Vestibulotoxicity in the Guinea Pig

Abstract

The study results suggest that topical administration of edaravone better suppresses streptomycin-induced vestibulotoxicity than systemic administration.

Protective effect of edaravone against the ototoxicity ofPseudomonas aeruginosaexotoxin A

“…These findings are quite similar to those observed when using L-NAME [10] or when using the aminoglycoside ototoxicity model [21,22]. Furthermore, we compared systemic and topical administration groups regarding the protective effects of edaravone.…”

“…The results indicated that topical administration suppressed PaExoA-induced auditory disorders better than systemic administration. A similar result was also observed regarding streptomycin-induced vestibulotoxicity [22]. Why topical administration should have been superior to systemic administration was not evident, but the high concentration of edaravone in the inner ear may have been responsible.…”

“…The free radical scavenger edaravone is reported [17,19] to be capable of directly trapping a variety of free radical species and of reacting with hydroxyl or peroxyl radicals to form certain oxidized compounds. In the inner ear, it has been reported that edaravone alleviates the damage caused by acoustic trauma [20], aminoglycoside ototoxicity [21,22] and Figure 2. When PaExoA was instilled i.t., followed by saline i.v., the ABR threshold was impaired in all rats (NaCl).…”

Instability Due to Drug-Induced Vestibulotoxicity

“…Aminoglycosides are capable of stimulating the formation of reactive oxygen species that play an important role in inner ear damage. This damage is ameliorated by the presence of free radical scavengers [11] . The presence of nitric oxide synthase was demonstrated in the vestibular epithelium.…”

Protective effect of edaravone against tobramycin-induced ototoxicity

“…Edaravone is a free radical scavenger capable of trapping several free radicals. In the inner ear, edaravone has demonstrated a protective effect on noise-induced cochleopathy in the guinea pig [9], in streptomycin-induced vestibulotoxicity in the guinea pig [18], and in Pseudomonas aeruginosa-inflicted cochleopathy in rat [8].…”