Effect of embelin against 3-nitropropionic acid-induced Huntington's disease in rats

Dhadde, Shivsharan B.; Nagakannan, P.; Roopesh, M.S.; Kumar, Sadish; Thippeswamy, B.S.; Veerapur, Veeresh P.; Badami, Shrishailappa

doi:10.1016/j.biopha.2015.11.009

Cited by 79 publications

(44 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When compared with dexamethasone embelin showed good antioxidant activity against LPS‐induced oxidative stress in mice brain. In our laboratory, we demonstrated the protective effect of embelin against transient global ischemia in rats (Thippeswamy et al , ) and 3‐nitropropionic acid induced Huntington's disease in mice (Dhadde et al , ), and the possible mode of action is attributed to its antioxidant activities. Hence, the beneficial effects obtained in the present study might also because of the antioxidant activities of embelin.…”

Section: Discussionmentioning

confidence: 94%

“…) is a naturally occurring alkyl substituted hydroxyl benzoquinone and a major constituent from all the parts of Embelia ribes Burm. Embelin is reported to possess antioxidant (Singh et al , ), antiinflammatory, antitumour, analgesic (Chitra et al , ; Mahendran et al , ), anticonvulsant (Mahendran et al , ), neuroprotective (Thippeswamy et al , ), anxiolytic (Afzal et al , ), antidepressant (Gupta et al , ) and anti‐Huntington's (Dhadde et al , ) activities. It is also reported to impair the inflammatory signalling through inhibition of NFκB pathway (Ahn et al , ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Embelin Against Lipopolysaccharide‐induced Sickness Behaviour in Mice

Shaikh

Dhadde²,

Durg

et al. 2016

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

Sickness behaviour is a coordinated set of adaptive behavioural changes that develop in ill individuals during the course of an infection. It is relevant to understanding depression and some aspects of the suffering that in cancer. Embelin has been reported to possess antiinflammatory, neuroprotective and anxiolytic assets and has been shown to inhibit nuclear factor κB pathway and cytokine production. The present study was undertaken to investigate the effect of embelin isolated from Embelia ribes Burm in lipopolysaccharide (LPS)-induced sickness behaviour in mice. Adult male Swiss albino mice were pre-treated with embelin (10 and 20 mg/kg, p.o.) or dexamethasone (1 mg/kg, i.p.) for 3 days and then challenged with LPS (400 µg/kg, i.p.). At different time intervals of post-LPS challenge, sickness behaviour was evaluated in the animals by battery of behavioural tests (plus maze, open field, light-dark box, forced swim, social behaviour assessment, sucrose preference and food and water intake). Levels of oxidative stress makers (reduced glutathione and lipid peroxidation) in mice brain were also analysed. LPS induced behavioural alterations, anhedonia and anorexia, in mice. Pre-treatment with embelin attenuated behavioural changes induced by LPS. In addition, embelin prevented anhedonia, anorexia and ameliorated brain oxidative stress markers. The experimental outcomes of the present study demonstrated protective effect of embelin in LPS-induced sickness behaviour in mice. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Effect of Embelin Against Lipopolysaccharide‐induced Sickness Behaviour in Mice

Shaikh

Dhadde²,

Durg

et al. 2016

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Huntington's disease is a progressive neurological disorder which is mainly characterized by clinical triad movement disorder, dementia and psychiatric disturbance due to striatal-specific neuronal degeneration [17,18]. Although the exact cause of neuronal death in HD remains unknown, it has been postulated that the abnormal aggregation of the mutant huntingtin protein may cause toxic effects in neurons leading to a cascade of pathogenic mechanisms associated with transcriptional dysfunction, oxidative stress, mitochondrial alterations, apoptosis, bioenergetic defects and subsequent excitotoxicity [19].…”

Section: Role Of Embelin In Huntington's Disease (Hd)mentioning

confidence: 99%

Embelin as a Potential Drug Molecule: A Review

Kumar¹,

Deshmukh²

2017

J Pharmacogn Nat Prod

View full text Add to dashboard Cite

Embelia ribes are traditionally used medicinal remedies in India. Embelin is a hydroxyl benzoquinone with alkyl substitution and is considered as one of the main constituents. Embelin has various biological activities includes anticonvulsant, antidepressant, antidiabetic, antifertility, antitumor etc. This review is an overall overview of the existing pharmacology of E. ribes, helping to fuel further research in the various unexplored activities that are attributable to this plant.

show abstract

“…The results show that eugenol treated cells have decreased oxidative markers and increased glutathione (GSH) levels [28]. Table 1 Huntington's Disease is characterized by striatal neuronal degeneration that may be due to the aggregation of mutant huntingtin protein [29]. Oxidative stress is evident in Huntington's disease in the reduction of Complex II/III activity in the mitochondrial electron transport chain, superoxide dismutase I and glutathione peroxidase [30].…”

Section: Phytochemical Protectionmentioning

confidence: 99%

“…3-nitropropionic acid causes mitochondrial dysfunction by disrupting oxidative phosphorylation and the electron transport chain due to its inhibition of succinate dehydrogenase and mitochondrial complex II thereby causing a Huntington's phenotype [30,31]. Embelin, from Embelia ribes, was tested against 3-nitropropionic acid oxidative damage in adult Wistar rats and showed that when embelin, 10 or 20 mg/kg/day oral, was administered with 3-nitropropionic, 15 mg/kg/day intraperitoneal, after 8 days of damage by 3-nitropropionic acid, there was a reversal of striatal neuronal damage, and a decrease in brain lesion area >69% (p < 0.001), improved behaviour and decreased oxidative stress [29].…”

Section: Phytochemical Protectionmentioning

confidence: 99%

Phytochemical treatments target kynurenine pathway induced oxidative stress

Parasram

2017

Redox Report

View full text Add to dashboard Cite

Objective: The objective of this paper was to link the phytochemical and metabolic research treating quinolinic acid induced oxidative stress in neurodegenerative disorders. Methods: Quinolinic acid, a metabolite of the kynurenine pathway of tryptophan catabolism, plays a role in the oxidative stress associated with many neurological disorders and is used to simulate disorders such as Parkinson's disease. Results: In these models, phytochemicals have been shown to reduce striatal lesion size, reduce inflammation and prevent lipid peroxidation caused by quinolinic acid. Conclusion: These results suggest that phenolic compounds, a class of phytochemicals, including flavonoids and diarylheptanoids, should be further studied to develop new treatments for oxidative stress related neurological disorders.

show abstract

Effect of embelin against 3-nitropropionic acid-induced Huntington's disease in rats

Cited by 79 publications

References 40 publications

Effect of Embelin Against Lipopolysaccharide‐induced Sickness Behaviour in Mice

Effect of Embelin Against Lipopolysaccharide‐induced Sickness Behaviour in Mice

Embelin as a Potential Drug Molecule: A Review

Phytochemical treatments target kynurenine pathway induced oxidative stress

Contact Info

Product

Resources

About