Effect of Epinephrine on the Dog Heart During Methoxyflurane Anesthesia

Bamforth, Betty J.; Siebecker, Karl L.; Kraemer, Richard; Orth, O. S.

doi:10.1097/00000542-196103000-00002

Cited by 28 publications

(4 citation statements)

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“…13 ' 14 The arrhythmias seen in "hyperthyroid" dogs during anaesthesia with 1 per cent methoxyflurane, 4.8 per cent trifluoroethylvinyl ether, and given a standard dose of epinephrine, are much more severe than previously reported in euthyroid dogs, or in this series with euthyroid dogs during thiopental -nitrous oxide anaesthesia. 15 " 18 There were no spontaneous arrhythmias seen in any of the "hyperthyroid" animals prior to the epinephrine challenge.…”

Section: Discussionmentioning

confidence: 92%

“…The dogs anaesthetized with thiopental -nitrous oxide had the same incidence of arrhythmias in the euthyroid state as has been seen previously with methoxyflurane and trifluoroethylvinyl ether. 15 ' 17> 18 In the hyperthyroid state, the dogs anaesthetized with methoxyflurane and trifluorqethylvinyl ether had a similar incidence of severe arrhythmias to those anaesthetized with thiopental -nitrous oxide.…”

Section: Discussionmentioning

confidence: 99%

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The cardiac effect of epinephrine during anaesthesia in hyperthyroid dogs

1962

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PATIENTS WITH HYPERTHYROIDISM may develop symptoms and signs of severe toxicity during, or in association with, anaesthesia and surgery. These symptoms may vary from mild tremors and severe tachycardia to full-blown thyroid storm. 1 Mo'st frequently, the disease causes an abnormal cardiac rate or rhythm. 2 ' 3 ' 4 Murray and his associates demonstrated that an epinephrine challenge is well tolerated by a euthyroid patient, but it causes marked discomfort to the hyperthyroid individual. 5 High spinal anaesthesia has been used by some to deafferent the adrenals, while others have used n hypothermia and neuroplegks in preparing their patients for thyroidectomy, in order to reduce the amount of catecholamines in the circulation. 6i7>8 This study was undertaken to determine whether or not the hyperthyroid state alters the response to a standard epinephrin,e challenge during anaesthesia in dogs. METHOD

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The cardiac effect of epinephrine during anaesthesia in hyperthyroid dogs

1962

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“…(44) found that by using a standardized technique of infusing epinephrine in dogs they could readily produce atrioventricular block and concluded that methoxyflurane was similar to chloroform but not as potent as cyclopropane in sensitizing the heart to epinephrine. Dobkin & Israel (45) found the arrhythmias provoked by an epinephrine challenge during methoxyflurane anesthesia in dogs were less severe than those seen in similar experiments with trichloroethylene, cyclopropane or halothane, but were similar to those seen with halothane-ether azeotrope or light chloroform.…”

Section: Anesthetic Aspectsmentioning

confidence: 99%

The Smaller Halogenated Aliphatic Hydrocarbons

Chenoweth¹,

Hake²

1962

Annu. Rev. Pharmacol.

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“…Unlike halothane, which causes vasodilation unrelated to concentration, it causes little change in the state of the peripheral vasculature, and the blood vessels retain their responsiveness at all levels of clinical anaesthesia (Black and McArdle, 1965). In addition, since it causes only minimal myocardial sensitization to catecholamines (Bamforth et al, 1961) and arrhythmias are unlikely to be associated with its use (Black and Roe, 1964;Black, 1967), the judicious use of adrenaline by the surgeon would not seem to be contraindicated.…”

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confidence: 99%