Effect Of Estrogen and Progesterone on Feed Intake and Hydroxyproline Excretion Following Induced Hypocalcemia in Dairy Cows

Muir, Larry A.; Hibbs, J.W.; Conrad, H.R.; Smith, Kenneth L.

doi:10.3168/jds.s0022-0302(72)85729-1

Cited by 29 publications

(13 citation statements)

References 12 publications

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“…It is not clear in what manner the feeding level influences Ca homeostatis. Probably it can be partly explained by the reduced appetite around parturition after higher feed intake during the dry period as was observed in the present experiment and also by Malestein and Van de Geer (25).The elevated plasma level of oestrogens around parturition can also depress appetite, as was often observed(2,28,29).Zamet et al (36) compared the effect of 3 different rations on the incidence of peripartal disorders. Cows on one of the diets showed a higher incidence of parturient paresis.…”

supporting

confidence: 51%

“…Therefore, in these groups R is probably a better indicator of the Ca mobilization capabilities of the cows.Table 6shows plasma levels of Ca, Mg and Pi at the start and end of Na,EDTA infusion. It should be noted that the 10 h pp28 plasma Ca levels "in the HCa high parity group, were significantly lower than in the LCa high parity group. The differences in Na,EDTA required may be partly caused by the differences in plasma Ca levels at the start of infusion.…”

mentioning

confidence: 85%

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Influence of prepartum calcium intake on calcium mobilization rate around parturition in dairy cows fed at a high prepartum feeding level

Braak¹,

At²,

Malestein³

1986

Veterinary Quarterly

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The influence of a low and a high prepartum calcium (Ca) intake on Ca mobilization rate around parturition was studied in 44 dairy cows fed a ration sufficient for 1.90 times maintenance requirements during the dry period. The plasma Ca level declined on the day of parturition in the group fed the low Ca intake (LCa: 26.4 g/d) as well as in the group fed the high Ca intake (HCa: 87.2 g/d). Plasma Ca levels of the HCa group were lower at parturition, and in this group 1 cow had milk fever after parturition. In the HCa group 6 cows had a plasma Ca level less than or equal to 2.0 mmol/l at parturition and/or 10 h post-partum (pp), versus 1 cow in the LCa group. Na2EDTA was intravenously infused at 10 h pp to induce hypocalcaemia to a level of plasma Ca not bound to EDTA of approximately 1.0 mmol/l. The LCa groups tended to require more Na2EDTA than the HCa groups, however the difference was significant only in the younger cows. After the Na2EDTA infusion 7 cows of the HCa group and 1 of the LCa group did not recover spontaneously and needed to be treated. The mean plasma PTH levels of the LCa group ante-partum were slightly higher than those of the HCa group. The Ca level of the prepartum ration did not influence urinary hydroxyproline excretion, which suggests that the Ca intake of 26.4 g/d was too high to stimulate bone turnover. Comparison of the present results with those of an earlier experiment in which the prepartum Ca intake at a low feeding level (1.12 times maintenance) was studied, led to the conclusion that higher prepartum feed intake has a clear negative influence on Ca homeostasis around parturition.

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supporting

confidence: 51%

mentioning

confidence: 85%

Influence of prepartum calcium intake on calcium mobilization rate around parturition in dairy cows fed at a high prepartum feeding level

Braak¹,

At²,

Malestein³

1986

Veterinary Quarterly

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“…Many of these markers are evaluated by urinary concentration [15], but it is difficult to collect urine from cows, especially in the field. Hpr concentration in the blood and urine are usually used for the evaluation of bovine bone metabolism [4,5,17]. But measuring Hpr concentration is a complicated and time-consuming process [2,12].…”

mentioning

confidence: 99%

Association between Chages in Plasma Calcium Concentration and Plasma Tartrate-Resistant Acid Phosphatase Activity in Periparturient Cows.

Sato

Takagi

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. Eight periparturient Holstein Friesian cows were examined for plasma tartrate-resistant acid phosphatase (TRAP) activity to assess the degree of bone metabolic activity and to evaluate the association between the change in calcium (Ca) concentration and bone metabolism during the periparturient period. Milk fever occurred in 1 of 8 cows just after parturition. Plasma TRAP activities did not markedly change in 5 of 8 cows during the experimental period. The changing rate of Ca between preparturition and just after parturition was under -20% in 3 of 8 cows, and low TRAP activities were observed in 2 of these 3 cows. This study suggests that cows with a low TRAP activity are at risk of developing milk fever in comparison to cows with high TRAP activity. Temporary increases of parathyroid hormone were observed in 7 cows, but not in the cow with milk fever. KEY WORDS: bovine, milk fever, TRAP.

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“…7mg%), as was induced by YARRINGTON et al (34) possibly demonstrates insufficiently the compensation possibilities of cows, because the second phase is not reached. In our opinion this occurs also in experiments in which a fixed quantity of chelating agent per cow or per kg B. W. is infused (4, 8,25,28,32). We therefore suggest that Na2EDTA infusion must be continued until the cow starts to show the clinical signs of hypocalcaemia, as was done in the present experiments and by others (5,9,30).…”

Section: Induction Of Hypocalcaemiamentioning

confidence: 89%

Influence of Stage of Lactation and Calcium Level of the Ration on Mobilisation Rate of Calcium and Excretion of Hydroxyproline in Urine in dairy Cows. Studies with Na₂EDTA Infusions in Monozygotic Twins

Braak

Klooster

Gestel

et al. 1984

Zentralblatt für Veterinärmedizin Reihe A

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Summary Ca metabolism of dairy cows was studied with 4 pairs of monozygotic twins of the Meuse Rhine Yssel breed. At parturition and at several stages of lactation as well as in the dry period hypocalcaemia was induced by i. v. Na2EDTA infusion until the level of plasma Ca not bound to EDTA was approx. 1.0 mM. The Ca mobilisation rate (R) during the infusion period was calculated from plasma concentrations of Ca bound and not bound to EDTA. The amount of Na2EDTA that could be infused was highly correlated with the calculated R (r = 0.87). Both parameters were influenced by the rate of infusion, the stage of lactation and the Ca intake per day. Urine hydroxyproline excretion was used to estimate the contribution of the skeleton to the Ca homoeostasis. The urine hydroxyproline/creatinine (h/c) ratio was influenced by the Ca intake per day and the stage of lactation. The correlation between the urine h/c ratio before the EDTA test and the amount of Na2EDTA that could be infused was calculated as 0.79. The importance of the Ca level to which the hypocalcaemia is induced, the time of the EDTA test with respect to parturition and the influence of parturition on hydroxyproline and creatinine excretion are discussed. Zusammenfassung Einfluß des Laktationsstadiums und des Kalziumgehaltes der Ration auf die Kalziummobilisierungsrate und die Hydroxyprolinausscheidung im Ham von Milchkühen Untersuchungen mit Na2EDTA‐Infusionen bei monozygoten Zwillingen An 4 Paaren von monozygoten Zwillingen der Meuse‐Rhine‐Yssel‐Rasse wurde der Ca‐Metabolismus von Milchkühen untersucht. Bei der Abkalbung, in unterschiedlichen Stadien der Laktation und während des Trockenstehens wurde durch i. v. Infusion von Na2EDTA eine Hypokalzämie induziert, bis der Spiegel des nicht an EDTA gebundenen Ca etwa 1,0 mmol/l betrug. Die Ca‐Mobilisierungsrate (R) während der Infusionsperiode wurde errechnet aus den Plasmakonzentrationen von Ca, das an EDTA gebunden bzw. nicht gebunden war. Die Menge von Na2EDTA, die infundiert werden konnte, war hoch korreliert mit dem errechneten R (r = 0,87). Beide Parameter wurden beeinflußt durch die Infusionsrate, das Laktationsstadium und die tägliche Kalziumaufnahme. Die Hydroxyprolinausscheidung im Harn diente zur Schätzung des Beitrages des Skeletts zur Ca‐Homöostase. Der Hydroxyprolin/Kreatinin‐Quotient (h/c) wurde beeinflußt durch die tägliche Kalziumaufnahme und das Laktationsstadium. Der Korrelationskoeffizient zwischen dem Harn‐h/c‐Quotienten vor dem EDTA‐Test und der Menge des infundierbaren Na2EDTA betrug 0,79. Die Bedeutung des Kalziumspiegels am Ende der Induktion der Hypokalzämie, die zeitliche Relation des EDTA‐Tests zur Abkalbung sowie der Einfluß der Abkalbung auf die Hydroxyprolin‐ und Kreatininausscheidung werden diskutiert. Resume Influence du stade de la lactation et du taux du calcium de la ration sur les taux de mobilisation du calcium et de l'excrétion de l'hydroxyproline dans l'urine des vaches laitières Recherches avec des infusions‐Na2EDTA chez des jumeaux monozygotes La métabolisme du calcium ...

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Effect Of Estrogen and Progesterone on Feed Intake and Hydroxyproline Excretion Following Induced Hypocalcemia in Dairy Cows

Cited by 29 publications

References 12 publications

Influence of prepartum calcium intake on calcium mobilization rate around parturition in dairy cows fed at a high prepartum feeding level

Influence of prepartum calcium intake on calcium mobilization rate around parturition in dairy cows fed at a high prepartum feeding level

Association between Chages in Plasma Calcium Concentration and Plasma Tartrate-Resistant Acid Phosphatase Activity in Periparturient Cows.

Influence of Stage of Lactation and Calcium Level of the Ration on Mobilisation Rate of Calcium and Excretion of Hydroxyproline in Urine in dairy Cows. Studies with Na₂EDTA Infusions in Monozygotic Twins

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Effect Of Estrogen and Progesterone on Feed Intake and Hydroxyproline Excretion Following Induced Hypocalcemia in Dairy Cows

Cited by 29 publications

References 12 publications

Influence of prepartum calcium intake on calcium mobilization rate around parturition in dairy cows fed at a high prepartum feeding level

Influence of prepartum calcium intake on calcium mobilization rate around parturition in dairy cows fed at a high prepartum feeding level

Association between Chages in Plasma Calcium Concentration and Plasma Tartrate-Resistant Acid Phosphatase Activity in Periparturient Cows.

Influence of Stage of Lactation and Calcium Level of the Ration on Mobilisation Rate of Calcium and Excretion of Hydroxyproline in Urine in dairy Cows. Studies with Na2EDTA Infusions in Monozygotic Twins

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Influence of Stage of Lactation and Calcium Level of the Ration on Mobilisation Rate of Calcium and Excretion of Hydroxyproline in Urine in dairy Cows. Studies with Na₂EDTA Infusions in Monozygotic Twins