Effect of Estrogens and Androgens Alone and in Combination with Chorionic Gonadotropin on the Ovary of the Hypophysectomized Rat

Hormonal regulation of preovulatory follicle maturation in the rat

“…While FSH plays a major role in these changes, several studies attest to the importance of intraovarian oestrogens acting locally to regulate follicular responses to gonadotrophins (e.g. Pencharz, 1940;Williams, 1940;Smith & Bradbury, 1963). Studies with hypophysectomized immature female rats given graded doses of diethylstilboestrol showed that oestrogen stimulated ovarian weight and that this response was the product of a reduction in follicular atresia and a concomitant stimulation of preantral follicle growth (Payne & Hellbaum, 1955).…”

Effects of clomiphene citrate on ovarian function in hypophysectomized rats

“…It appears that the early phase of follicular development ensuring gonadotrophin-induced ovulation is oestrogendependent, and that administration of clomiphene citrate has detrimental effect(s) on this process. Oestrogens have been shown to stimulate ovarian function directly and to promote follicular growth (Pencharz, 1940;Williams, 1940;Richards et al, 1976) and to prevent follicular atresia (Reiter et al, 1972;Louvet et al, 1975). The antiovulatory and ovarian weight-limiting actions of clomiphene citrate observed in the present study may therefore be viewed as oestrogenantagonistic.…”

Effects of Ablation of the Submaxillary Gland in Guinea Pigs

“…Likewise, the effect of oestrogen on the ovaries after the hypophy sectomy in the rats was confirmed by other authors. Pencharz (1940) has noted that there is an increased ovarian size due to enlargement of follicles following the treatment of hypophysectomized rats with estrogen and gonadotrophin.…”