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TWO TEXT FIGWS AND TWO PLATES (FOUR FIGURES)I n a preliminary report (Pencharz and Long, '31) on the effect of hypophysectomy in the pregnant rat, it was stated that removal of the anterior and posterior portions of the gland between the eleventh and twentieth days of pregnancy was followed by a lengthening of the gestation period by from 3 to 4 days. On the other hand, in those instances in which fragments of the gland had been inadvertently left behind, gestation was normal or disturbed, depending upon the amount of tissue left in situ. Since that announcement, experiments have been extended to include earlier stages of pregnancy, and the present paper is a detailed report of the earlier observations and of the more recent studies.I n the paper referred to above it mas also stated that in those instances in which the operation was complete and no tissue could be detected at autopsy and by serial sections of the pituitary region, the rats died at the end of a prolonged gestation period without being able to expel their young, In the more recent studies a number of animals survived, dead and living young being born several days beyond term.So far as the writers are aware, the literature contains an account of only two short series of experiments dealing with the effects of total hypophysectomy in the pregnant animal, The first group of experiments was carried out by Aschner in 1912 on three pregnant dogs, in which ablation of the hypophysis was followed by abortion in from 3 to 12 days. after the operation.

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