RELATION BETWEEN THE GROWTH PROMOTING EFFECTS OF THE PITUITARY AND THE THYROID HORMONE¹¹

Metabolic Effects of Human Growth Hormone and Growth Hormone of Other Species in Man

“…There were no detectable metabolic effects; the calcium and sodium balances remained stationary. DISCUSSION The striking feature of these and other studies (2,3,4,21) with HGH has been the almost uniform retention of nitrogen noted in the adult. The amount of nitrogen retained has varied between 2 and 4 Gm.…”

“…Only occasionally has the sodium retention been accompanied by increased aldosterone secretion (2), and in one series a rise in aldosterone secretion was not observed (4). During the early studies with growth hormone, it was observed that thyroid hormone greatly increased the degree of nitrogen retention promoted by growth hormone in the rat (21). In our 2 studies, HGH was shown to be effective in patients with hypothyroidism, and the addition of triiodothyronine to the regimen in one patient led to questionable enhancement of the anabolic potency of HGH.…”

The Effects of Nutritional and Endocrine Factors on an Inherited Retinal Degeneration in the Mouse

“…Evans and co-workers, in studying the influence of endocrine factors upon growth in young rats, concluded that increases in body weight, visceral weight, and skeletal dimensions were mainly promoted by the pituitary growth hormone, whereas thyroxin was concerned with effecting maturation of skeleton, hair, and endocrine glands ; the optimal balance between these characteris¬ tics was obtained by a combination of both hormones (Evans, Simpson, and Pencharz, 1939;Scow and Marx, 1945;Scow, Simp¬ son, Asling, Li, and Evans, 1949;Ray, Simpson, Li, Asling, and Evans, 1950). At 60 days, the brains and eyeballs of rats thyroidectomized at birth were somewhat lighter than those of controls of the same age, but, in proportion to the diminished body weight, they were two to three times heavier than normal (Scow and Simpson, 1945;Scow and others, 1949).…”

The Effect of Prolonged Thyroxine Treatment on the Ageing Male Rat

“…Therefore growth cessation in the middle aged male rat cannot be due to a deficiency of thyroxine. The growth stimulating action of thyroxine is only observed in hypothyroid animals as in thyroidectomized (Evans et al, 1939;Scow et ah, 1949;Eartly and Leblond, 1954) or hypophysectomized rats (Laqueur et ah, 1941;Asling et ah, 1954).…”