Effect of ethanolic extract of Khaya senegalensis on some biochemical parameters of rat kidney

Adebayo, Joseph O.; Yakubu, Musa Toyin; Egwim, Evans Chidi; Owoyele, Bamidele Victor; Enaibe, Bernard Ufuoma

doi:10.1016/s0378-8741(03)00193-4

Cited by 62 publications

(52 citation statements)

References 10 publications

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“…Phenolics are well known for their diverse physiological properties, including among others, anti-carcinogenic, anti-inflammatory and anti-parasitic properties (Hilou et al, 2006). The initial low percentage chemosuppression observed in the extract-treated group compared to the chloroquine-treated group (Table 2) may be due to the fact that the extract at the dose administered had not accumulated sufficiently to bring about considerable chemosuppression (Adebayo et al, 2003) or it has a lower speed of action compared to chloroquine. However, the prolonged administration of the extract led to the total clearance of the parasites.…”

Section: Discussionmentioning

confidence: 99%

“…200 g of the powder was percolated in 1600ml of absolute ethanol and kept in the shade for 48 hours after which it was filtered. The filtrate was collected in a beaker, exposed to air and allowed to evaporate at room temperature to yield the extract concentrate (Adebayo et al, 2003) giving a percentage yield of 8.3%. Preliminary qualitative and quantitative phytochemical screening of the plant extract was carried out employing standard procedures (Harbone, 1983).…”

Section: Introductionmentioning

confidence: 99%

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Activity of ethanolic extract of Clerodendrum violaceum leaves against Plasmodium berghei in mice

Balogun¹,

Adebayo²,

Zailani³

et al. 2010

ABJNA

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The antimalarial potential of the ethanolic extract of Clerodendrum violaceum leaves (13 mg/kg body weight) was investigated in mice infected with Plasmodium berghei. Haematological indices including the red blood cell indices, the white blood cell indices and platelet count were also evaluated on days 3, 8 and 14 after infection. Phytochemical screening revealed a predominance of alkaloids (3.68 %), and phenolics (2.78 %) in the extract. The extract suppressed parasitaemia following administration to infected mice by 92.3% on day 14 post-infection. The infected extracttreated animals had significantly higher (P<0.05) red blood cell count (RBC), packed cell volume (PCV), haemoglobin concentration (Hb), white blood cell count (WBC), and platelet count than the infected untreated animals. The results suggest that the extract possesses considerable antimalarial activity and may induce synthesis of red blood cells, white blood cells and platelets. These results support further studies on Clerodendrum violaceum leaf as a source of antimalarial remedy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Activity of ethanolic extract of Clerodendrum violaceum leaves against Plasmodium berghei in mice

Balogun¹,

Adebayo²,

Zailani³

et al. 2010

ABJNA

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“…The observed decrease in bilirubin levels in the present study agree with the earlier work of Aloy-Amadi et al, [42] who reported a decrease in bilirubin levels following intake of strong unfiltered coffee. Different authors have noted that assessment of levels of excretory metabolites such as electrolyte, urea, and creatinine can be used to evaluate renal function [43,44]. Urea is the main end product of protein catabolism [45].…”

Section: Resultsmentioning

confidence: 99%

“…Amino acid deamination takes place in the liver, which is also the site of urea cycle where ammonia released is converted into urea and is excreted through urine [43,46,47]. Urea varies directly with protein intake and inversely with the rate of excretion [44]. According to Ranjna [32], renal diseases which diminish the glomerular filtration lead to urea retention.…”

Section: Resultsmentioning

confidence: 99%

Effect of Caffeine on Some Selected Biochemical Parameters Using Rat Model

Agomuo

Majesty

Augustine

et al. 2017

Advances in Biology

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Effect of caffeine on some selected biochemical parameters using rat model was investigated. Standard methods of analysis were used for the study. A total of sixty (60) rats divided equally into five groups of which one group served as the control, and the rest as test groups were used. The test rats were placed on different concentrations of caffeine for twenty-eight (28) days. Results obtained for the selected biochemical parameters revealed that AST and ALT levels of the liver increased significantly ( < 0.05) in test rats against the control. Creatinine and electrolyte ions of the kidney increased significantly ( < 0.05) in test groups when compared to the control. Haematological indices such as WBC, monocytes, lymphocytes, MCV, MCHC, and MCV levels were significantly altered ( < 0.05) in test rats against those of the control. It therefore becomes imperative for those that consume caffeine with believe that it does more good work than harm to take note of these findings. This study has revealed the effect of caffeine on some selected biochemical parameters using rat model.

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“…24 The non-significant effect (p< 0.05) on the serum phosphate ion concentration shown by the animals except the diseased untreated control (Dc) may be as a result of phosphate ions not accumulated enough to produce significant change. 25 The initial reduction observed in the diseased control could indicate tubular dysfunction of the nephrons . …”

Section: IIImentioning

confidence: 99%

Effect of Determined Mineral Elements in Mesocarp of Balanites Aegyptiaca Fruit on Serum Electrolytes of Ccl4 Treated Rats

2013

IOSR-JPBS

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Effect of ethanolic extract of Khaya senegalensis on some biochemical parameters of rat kidney

Cited by 62 publications

References 10 publications

Activity of ethanolic extract of Clerodendrum violaceum leaves against Plasmodium berghei in mice

Activity of ethanolic extract of Clerodendrum violaceum leaves against Plasmodium berghei in mice

Effect of Caffeine on Some Selected Biochemical Parameters Using Rat Model

Effect of Determined Mineral Elements in Mesocarp of Balanites Aegyptiaca Fruit on Serum Electrolytes of Ccl4 Treated Rats

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