Effect of eugenol on animal models of nociception

Abstract

To investigate the antinociceptive potential of eugenol on different pain models Bharati Vidyapeeth Deemed in mice. University, Poona College of Pharmacy, Materials and Methods: Eugenol was evaluated (1-100 mg/kg, i.p.) in various Pune 411 038. experimentally induced pain models like, formalin induced hyperalgesia, acetic acid *Present Address: Discovery induced abdominal constrictions, and thermal pain experiment using Eddy's hot plate. Biology, Advinus Therapeutics, Results: Eugenol significantly inhibited acetic acid induced abdominal constrictions, Bioresearch Centre, with the maximal effect (92.73% inhibition) at 100 mg/kg. In formalin induced paw Pune 411057, licking pain model, eugenol exhibited more pronounced antinociceptive effect in the Maharashtra, India. inflammatory phase than the neurogenic phase (maximal effect was 70.33% and 42.22%, respectively, at 100 mg/kg, i.p). A mild reduction in the pain response latency at 100 Received: 31.3.2006 mg/kg, i.p. dose of eugenol was observed in the hotplate thermal pain studies in mice.

Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review

“…EUG showed a significant result in decreasing the pain. The effect of EUG in several experimental pain models using mice was studied such as acetic acid-mediated abdominal constrictions, formalin-mediated hyperalgesia, and thermal pains, and 92.73%, 70.33%, and mild inhibitions in pain were found, respectively [ 128 ].…”

Local Antinociceptive Effect of “Snow Mountain Garlic” in an Experimental Formalin Model

“…However, natural compounds have also shown a crucial antinociceptive effect. For example, eugenol (clove oil) has been studied with a good margin of success as shown by the works of Kurian et al, [35]; Apparecido et al [2]; Dal Bó et al, [37]; Lugo-Lugo et al [30] and González-Lugo et al, [36]. Other examples are the aguacate bone, alacrancillo grass, arnica, canastilla, cedar bark, the plant of the chilagogue, colcolmeca, cornizuelo, crucetillo, cuajilote, epazote, garlic (Allium sativum), etc.…”

ANALGESIC ED50 DICLOFENAC-EUGENOL COMBINATION EFFECT ON PROINFLAMMATORY CYTOKINES – IL-1β, IL-6, TNFα AND MAPKs – IN RAT MUSCLE

“…DFC is commonly used to treat long-term inflammatory disorders; however, due to its short half-life and some reports of toxicity, its use has been reduced [10,20]. Besides, EUG is a monoterpene extracted from clove (Syzygium aromaticum) that proved an antinociceptive effect in several pain models [14,17,19,24]. Because of its versatility, it is often used alone or in combination with nonsteroidal anti-inflammatory drugs such as acetylsalicylic acid, piroxicam, ketorolac and DFC [3,8,13,22].…”