Effect of eugenol on the genotoxicity of established mutagens in the liver

Rompelberg, C.J.M.; Evertz, S.J.C.J.; Bruijntjes-Rozier, G.C.D.M.; Heuvel, P.D. van den; Verhagen, Hans

doi:10.1016/0278-6915(95)00091-7

Cited by 51 publications

(16 citation statements)

References 27 publications

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“…The MIC of eugenol against C. albicans was 2 mg/mL, which is relatively higher than that in another report [15]. This difference could be due to the difference in C. albi cans strains tested, inoculum size, growth phase, the culture medium and pH used, and incubation time/temperature as previously reported [24].…”

Section: Discussioncontrasting

confidence: 42%

“…This difference could be due to the difference in C. albi cans strains tested, inoculum size, growth phase, the culture medium and pH used, and incubation time/temperature as previously reported [24]. Also, our isolates were resistant to fluconazole, and this did not inhibit the growth of both C. albicans isolates at 0.4 mg/mL, which is much higher than reported [15].…”

Section: Discussioncontrasting

confidence: 41%

“…Eugenol has a potent antifungal activity against Can dida, Aspergillus, and dermatophytes [15], which is mainly attributable to its phenolic hydroxyl group [16]. We are unaware of any reports on eugenol use for the treatment of keratomycosis.…”

Section: Doi: 101159/000488907mentioning

confidence: 99%

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Topical Eugenol Successfully Treats Experimental Candida albicans-Induced Keratitis

Hassan¹,

Geniady²,

Abdelwahab³

et al. 2018

Ophthalmic Res

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Purpose: To determine the efficacy of eugenol for the treatment of Candida keratitis in an experimental model. Methods: The in vitro antifungal activity of eugenol and fluconazole was tested against C. albicans strains via the microbroth dilution method. An experimental model of Candida albicans keratitis was used. Rabbits were classified into those that received no treatment (control; group 1) and those that started eugenol treatment immediately (group 2) or after 4 days (group 3) of keratitis induction (n = 12–16 rabbits/group). The 2 treatment groups were assigned to 50 μL of 4 mg/mL eugenol drops hourly for 15 days, while the control group received saline. Corneal penetration of eugenol was measured using HPLC, and corneal toxicity was evaluated clinically and histopathologically. Results: The in vitro minimum inhibitory concentrations of eugenol and fluconazole against C. albicans were 2 and > 0.4 mg/mL, respectively. A 4-mg/mL preparation of eugenol in propylene glycol was the maximum nontoxic dose on rabbit corneas as suggested by clinical and histopathologic findings. At least 75% of all eugenol-treated eyes recovered from keratitis, with improvement in the remaining 25% of the eyes compared to controls. Conclusions: Eugenol can act as a natural, safe, and effective treatment for fungal keratitis, regardless of whether treatment is started immediately or after 4 days of keratitis induction.

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Section: Discussioncontrasting

confidence: 42%

Section: Discussioncontrasting

confidence: 41%

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Topical Eugenol Successfully Treats Experimental Candida albicans-Induced Keratitis

Hassan¹,

Geniady²,

Abdelwahab³

et al. 2018

Ophthalmic Res

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“…8 Eugenol is also present in other aromatic plants like clove, cinnamon and nutmeg. 9 In a recent study, eugenol isolated from the cortex of Eugenol caryophyllata (clove) inhibited the activity and gene expression of inducible cyclooxygenase (COX-2) in lipopolysacharide (LPS) activated mouse macrophage cells. 10 COX-2 catalyzes the conversion of arachidonic acid to prostaglandins 11 and is an early response gene when stimulated by serum, tumor promoters, mitogens, endotoxin, cytokines and hormones.…”

mentioning

confidence: 99%

Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum

Nangia‐Makker

Tait

Shekhar

et al. 2007

Intl Journal of Cancer

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Ocimum sp. is a traditionally used medicinal herb, which shows anti-oxidant, anti-carcinogenic, radio-protective and free radical scavenging properties. So far no detailed studies have been reported on its effects on human cancers. Thus, we analyzed its effects on human breast cancer utilizing in vitro and in vivo methodologies. Aqueous extracts were prepared from the mature leaves of Ocimum gratissimum (OG) cultivated devoid of pesticides. Tumor progression and angiogenesis related processes like chemotaxis, proliferation, apoptosis, 3D growth and morphogenesis, angiogenesis and tumor growth were studied in the presence or absence of the extract, and in some experiments a comparison was made with purified commercially available eugenol, apigenin and ursolic acid. Aqueous OG leaf extract inhibits proliferation, migration, anchorage independent growth, 3D growth and morphogenesis and induction of COX-2 protein in breast cancer cells. A comparative analysis with eugenol, apigenin and ursolic acid showed that the inhibitory effects on chemotaxis and 3D morphogenesis of breast cancer cells were specific to OG extract. In addition, OG extracts reduced tumor size and neoangiogenesis in a MCF10 DCIS.com xenograft model of human DCIS. This is the first detailed report showing that OG leaf extract may be of value as a breast cancer preventive and therapeutic agent and might be considered as additional additive in the arsenal of components aimed at combating breast cancer progression and metastasis. ' 2007 Wiley-Liss, Inc.

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“…The ability of dietary factors to counteract the effects of aflatoxins has been studied. Rompelberg et al (1996) noted that phenolic compounds can metabolically enhance aflatoxin B1 conjugation and elimination. Galvano et al (2001) also noted that food components like fructose, phenolic compounds, coumarins, chlorophyll and food additives like piperine, aspartame, cyproheptadine and allyl sulfides can reduce the toxicity of mycotoxins by decreasing toxin formation and enhancing metabolism.…”

Section: To Prevent Aflatoxin C O N T a M I N A T I O N O F C O M M Omentioning

confidence: 99%

Strategies for the Prevention and Reduction of Mycotoxins in Developing Countries

Adegoke¹,

Letuma²

2013

Mycotoxin and Food Safety in Developing Countries

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Effect of eugenol on the genotoxicity of established mutagens in the liver

Cited by 51 publications

References 27 publications

Topical Eugenol Successfully Treats Experimental <b><i>Candida albicans</i></b>-Induced Keratitis

Topical Eugenol Successfully Treats Experimental <b><i>Candida albicans</i></b>-Induced Keratitis

Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum

Strategies for the Prevention and Reduction of Mycotoxins in Developing Countries

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