Effect of Excess Calcium Intake on Absorp-Tion of Nitrogen, Fat, Phosphorus and Calcium in Young Rats. The Use of Organic Calcium Salt

Goto, Susumu; Sawamura, Tsuneko

doi:10.3177/jnsv.19.355

Cited by 8 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, excess Ca does not affect the P concentration in the tissues. Goto and Sawamura (1973) showed that excess Ca decreased P absorption, but did not affect the P concentration in the femur and kidney. P mainly exists as a Ca complex, such as hydroxyapatite, in the skeletal tissue.…”

Section: Discussionmentioning

confidence: 99%

Effects of excess calcium as a different form on mineral metabolism in rats

Takasugi

Matsui

Yano

2005

Animal Science Journal

View full text Add to dashboard Cite

Excess calcium is known to affect the metabolism of other minerals. Calcium carbonate is the main source of calcium used in previous experiments that investigated excess calcium. Thus, it remains to be clarified whether other forms of calcium also have the same adverse effects. The effects of a high‐calcium carbonate diet or a high‐calcium citrate diet on mineral concentration in several tissues of rats were examined. Male rats aged 5 weeks were fed one of the experimental diets for 4 weeks. The control diet contained calcium as calcium carbonate at the requirement level. High‐calcium diets contained calcium carbonate or calcium citrate at a level of fivefold greater than the requirement level. In rats fed the high‐calcium diets, a similar decrease in phosphorus (in the plasma) and iron (in the testis, liver and femur) was observed. Hepatic copper increased in rats fed the high‐calcium diets, whereas renal copper decreased. Therefore, excess calcium affects these mineral metabolisms regardless of its form. In contrast, the high‐calcium carbonate diet increased femoral zinc and decreased femoral magnesium, but the high‐calcium citrate diet did not affect these minerals in the femur, which suggests that the effect of excess calcium on minerals partly depends on its form.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of excess calcium as a different form on mineral metabolism in rats

Takasugi

Matsui

Yano

2005

Animal Science Journal

View full text Add to dashboard Cite

show abstract

“…The negative hydroxyproline AID values are in agreement with previous work and may be related to increased turnover of the epithelium and or reduced gastrointestinal tract integrity . Work in rats has demonstrated that a high Ca diet is associated with reduced N retention (Goto and Sugai, 1975). Studies in broilers has shown that feed intake and the efficiency of N and amino acid digestion are negatively influenced with increasing dietary Ca concentration (Shafey and McDonald, 1991a).…”

Section: Tablementioning

confidence: 99%

Nutritional geometry of calcium and phosphorus nutrition in broiler chicks. The effect of different dietary calcium and phosphorus concentrations and ratios on nutrient digestibility

Wilkinson

Bradbury

Thomson

et al. 2014

animal

View full text Add to dashboard Cite

A total of 600 Ross 308-day-old male broiler chicks were used in a 28 day digestibility study to investigate the interaction between dietary calcium (Ca) and non-phytate phosphorus (nPP) on the digestibility of minerals and amino acids. Diets were formulated to be nutritionally adequate except for Ca and nPP. Fifteen mash diets based on corn and soya bean meal with varying concentrations of Ca (6.4 to 12.0 g/kg) and nPP (2.4 to 7.0 g/kg) were used. Diets were clustered around total densities of Ca and nPP of 12, 13.5 or 15.0 (g/kg) and within each density, a range of five Ca : nPP ratios (1.14 : 1, 1.5 : 1, 2.0 : 1, 2.75 : 1 and 4.0 : 1) were fed. Birds had free access to feed and water throughout the study. At day 28, birds were euthanised for the determination of apparent ileal mineral and amino acid digestibility. Data were modelled in R version 2.15 using a linear mixed-effects model and interrogation of the data was performed by fitting a low order polynomial function. At high Ca concentrations, increasing nPP led to an increase in the apparent digestibility of minerals. Apparent ileal digestibility of phosphorus (P) was enhanced with increasing dietary nPP up to 5.5 g/kg beyond which no improvements were found. Maximal Ca digestibility was found in diets with > 8.0 g/kg Ca with concomitant low concentrations of nPP. Diets with a broader Ca : nPP ratio improved the digestibility of Ca but were deleterious to the digestibility of P. In this study, apparent digestibility of amino acids was broadly unaffected by dietary Ca and nPP concentrations. However, interactions between Ca and nPP were observed for the digestibility of glutamine, tyrosine and methionine (all P < 0.001). Nitrogen digestibility showed discrete optima around 10.0 and 5.0 g/kg nPP and Na digestibility was maximised around 8 to 9.0 g/kg Ca and 4.5 to 5.4 g/kg nPP. These data show that the ratio of Ca : nPP is more influential to mineral digestibility than the absolute dietary concentration of each macro mineral.

show abstract

“…As noted, the depressant effect o f high dietary calcium on absorption o f fat has been recognized for many years (8)(9)(10)(11)(12)(13)(14). Although statistically significant in the present study, the decrease in fat absorption at the higher calcium intake was not large enough to be o f clinical significance.…”

Section: The Main Purpose O F This Study Was To Examine the Effect O mentioning

confidence: 99%

“…Thus, the findings are explainable in more than one way and do not necessarily demonstrate regulatory changes. (1)(2)(3)(4) and in human subjects (5-71, including the premature infant (8). High dietary intake of calcium also has been shown to depress absorption of fat in animals (9, 101, children ( I 1) and infants, both preterm (8, 12) and t e r n (13, 14).…”

mentioning

confidence: 99%

Effect of Dietary Calcium on Metabolic Balance of Normal Infants

et al. 1985

View full text Add to dashboard Cite

ABSTRACT. Metabolic balance studies were performed with six normal infants fed in a balanced cross-over design three formulas differing only in calcium concentration: 389, 659, and 1024 mgjliter, Absorption of phosplrorus was significantly affected by increasing calcium intake decreasing from 68 to 63 to 52% of intake. However, since urinary excretion of phosphorus also decreased, there was no significant effect on retention of phosphorus. Absorption of fat was slightly (but significantly) depressed by calcium, decreasing from 97.5 to 95.5 to 92.1% as calcium intake increased. 'The level of dietary calcium bad no significant effect on absorption or retention of nitrogen, magnesium, copper, and zinc. One of the subjects had consistently lower absorption of calcium and fat than the other subjects, suggesting an absorptive defect. The decrease in fractional absorption of calcium (57 to 47 to 39% of intake) with increasing intake of calcium is compatible with adaptive regulation. On the other hand, the observation that absorbed calcium (mg/kg/day) was linearly related to intake of salcium with a slope of 0.373 suggests an alternative explanation: constant passive, concentration-dependent (slope), and constant active (y-intercept) transport of calcium over the range of calcium intakes. Thus, the findings are explainable in more than one way and do not necessarily demonstrate regulatory changes. (1)(2)(3)(4) and in human subjects (5-71, including the premature infant (8). High dietary intake of calcium also has been shown to depress absorption of fat in animals (9, 101, children ( I 1) and infants, both preterm (8, 12) and t e r n (13, 14). A negative effect of high calcium intake on absorption of zinc has been demonstrated in animal studies (1 5-18), but balance studies in adult humans have not confirmed this effect (19)(20)(21)(22). Absorption of copper does not seem to be influenced by dietary calcium

show abstract

Effect of Excess Calcium Intake on Absorp-Tion of Nitrogen, Fat, Phosphorus and Calcium in Young Rats. The Use of Organic Calcium Salt

Cited by 8 publications

References 7 publications

Effects of excess calcium as a different form on mineral metabolism in rats

Effects of excess calcium as a different form on mineral metabolism in rats

Nutritional geometry of calcium and phosphorus nutrition in broiler chicks. The effect of different dietary calcium and phosphorus concentrations and ratios on nutrient digestibility

Effect of Dietary Calcium on Metabolic Balance of Normal Infants

Contact Info

Product

Resources

About