Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: A randomized clinical trial

Abstract

We determined the effects of 2 years of exercise training and soy isoflavone supplementation on bone mass and lipids in postmenopausal women provided with calcium and vitamin D. Women were randomized to four groups: exercise training (Ex); isoflavone supplementation (Iso: 165 mg/d [105 mg/d aglycone equivalent]); combined Ex and Iso (ExIso); and placebo (control). Exercise included resistance training (2 days/week) and walking (4 days/week). Our primary outcomes were lumbar spine and hip bone mineral density (BMD). Secondary outcomes included hip geometry, tibia and radius speed of sound (SOS), dynamic balance (6 m backward tandem walking), blood lipids, mammography, and endometrial thickness. Isoflavone supplementation did not increase endometrial thickness or abnormal mammograms. We conclude exercise training and isoflavone supplementation maintain hip BMD compared to control, but these two interventions interfere with each other when combined. Isoflavone supplementation decreased LDL and adverse events related to menopausal symptoms. ß

Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture

“…Coefficients of variation for these measures in our lab were 0.7 % for the lumbar spine and 1.0 % for the proximal femur [35]. Precision of aBMD has been reported as 1.9 % at the distal forearm [36].…”

Effects of Dietary Isoflavones from Puerariae Radix on Lipid and Bone Metabolism in Ovariectomized Rats

“…Although some studies have suggested that isoflavones have potential health benefits in postmenopausal women [9], a number of studies have also reported the absence of beneficial effects of isoflavones intake on classic metabolic parameters [10], such as body weight and serum lipid profiles. A number of randomized trials have also failed to show a sustained enhancement of bone by isoflavones supplements [11,12,13]. Since we currently lack consistent evidence to support any beneficial effect of isoflavones intake on menopausal symptoms, their efficacy needs to be scientifically evaluated in in vivo experiments.…”

Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling

“…102 The clinical application of this combined intervention further proved that the hip BMD of 351 postmenopausal women was well maintained in a study of 2-year exercise training (resistance training 2 d/week and walking 4 d/week) with dietary SI intake (165 mg/day). 103 This study is of clinical importance and may have valued implications for the prevention and treatment of postmenopausal osteoporosis.…”