Effect of Experimental Renal Hypertension on Experimental Thiouracil-Cholesterol Atherosclerosis in Dogs

Wakerlin, G. E.; Moss, W. G.; Kiely, J. P.; Fein, Gloria; Kejikawa, Frank

doi:10.1161/01.res.5.4.426

Cited by 46 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there are several significant morphologic and biochemical events that are characteristic of sustained hypertension. These include: (1) thickening and stiffening of the arteries; (2) hyperplasia and hypertrophy of arterial smooth muscle; (3) increased arterial tissue content of elastin, collagen, and acid mucopolysaccharides; and, (4) increased water and salt content, e.g., Na+, Ca++, and C1-. [6][7][8] All the data appear to indicate that changes in connective tissue metabolism and endothelial permeability associated with atherosclerosis are increased by hypertension.…”

Section: Experimental Studiesmentioning

confidence: 99%

Renin as a Predictor of Hypertensive Complications*

Kirkendall¹,

Hammond²,

Overturf³

1978

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

Section: Experimental Studiesmentioning

confidence: 99%

Renin as a Predictor of Hypertensive Complications*

Kirkendall¹,

Hammond²,

Overturf³

1978

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…A role for hypertension in atherogenesis is unequivocally based on the evidence that atherosclerotic plaques never develop in low‐pressure districts of the circulation. However, in some experimental models, atherosclerosis could be induced by hypertension only when high serum lipid levels were concomitant [3–5]. Moreover, reducing blood pressure levels did not by itself lead to regression of the atheromatous lesions, whereas this occurred when lipid concentrations were also lowered [6].…”

Section: Introductionmentioning

confidence: 99%

Coronary artery disease and arterial hypertension: clinical, angiographic and follow‐up data

Natali

Vichi

Landi

et al. 2000

Journal of Internal Medicine

View full text Add to dashboard Cite

Abstract. Natali A, Vichi S, Landi P, Toschi E, Severi S, L'Abbate A, Ferrannini E (C.N.R. Institute of Clinical Physiology and the University of Pisa, Pisa, Italy). Coronary artery disease and arterial hypertension: clinical, angiographic and follow-up data. J Intern Med 2000; 247: 219±230.Objectives. To evaluate how the presence of arterial hypertension affects coronary atherosclerosis and prognosis in patients with, or at high risk of, ischaemic heart disease. Design. Retrospective analysis of clinical records and follow-up data. Settings. Single referral centre for ischaemic heart disease. Subjects. All consecutive patients (n = 1700, 38% with hypertension) undergoing coronary angiography for the evaluation of ischaemic heart disease during 1983±92. Results. On angiography, the likelihood of having three-vessel disease was higher amongst hypertensives (odds ratio = 1.41; 95% confidence interval [CI] = 1.08±1.85) after adjustment for age, sex, and angina symptoms. The sum of all visible stenoses (an index of overall atherosclerotic involvement) was 19% higher in hypertensives (262 6 204 vs. 220 6 194 units, P , 0.005). By multivariate analysis, the presence of hypertension made a modest (+ 28 units), albeit statistically significant, independent contribution to the total atherosclerosis score. On follow-up (median = 96 months), cardiovascular mortality was slightly higher in the hypertensive patients than in the normotensive group (P , 0.05 in a Kaplan±Meier analysis), but a proportional hazard analysis adjusting for age and gender showed no significant independent contribution of hypertension. Hypertensive patients, however, remained at higher risk of non-fatal myocardial infarction following discharge (adjusted odds ratio = 1.21, 95% CI = 1.03±1.46; P , 0.05). Conclusions. In this referral population, hypertension is a risk factor for presence of three-vessel disease. Distribution, severity and extension of coronary stenosis are similar to those of normotensive patients, and prognosis is only marginally affected.

show abstract

“…The enhancing effect of hypertension on atherosclerosis in man and experimental animals is well recognized (1,2,3,4). However, the precise mechanism by which this occurs has not been well documented.…”

mentioning

confidence: 99%

Regional differences in cholesterol content of aorta in response to experimental coarctation in spontaneously atherosclerosis-susceptible pigeons

Subbiah

Kottke

et al. 1980

Basic Res Cardiol

View full text Add to dashboard Cite

The effect of experimental coarctation of the aorta at a site above the coeliac bifurcation (site of occurance of spontaneous atherosclerotic lesions) in White Carneau pigeons was examined. Cholesterol content of the aorta in the site where spontaneous atherosclerosis usually occurs (coeliac bifurcation = lesion site) was decreased in pigeons with aortic coarctation. On the other hand, in the region proximal to the site of coarctation which is usually free of atherosclerotic events cholesterol accumulation was increased. A decrease in percent composition of oleic acid (the major fatty acid which increases during atherosclerosis) was noted in the lesion site. These studies have shown regional differences in response of aorta to experimental coarctation in spontaneously atherosclerotic-susceptible pigeons and suggest that lowering of blood pressure at lesion site might decrease cholesterol accumulation and perhaps might retard subsequent atherogenic process.

show abstract

Effect of Experimental Renal Hypertension on Experimental Thiouracil-Cholesterol Atherosclerosis in Dogs

Cited by 46 publications

References 6 publications

Renin as a Predictor of Hypertensive Complications*

Renin as a Predictor of Hypertensive Complications*

Coronary artery disease and arterial hypertension: clinical, angiographic and follow‐up data

Regional differences in cholesterol content of aorta in response to experimental coarctation in spontaneously atherosclerosis-susceptible pigeons

Contact Info

Product

Resources

About