Effect of Exposure to Quran Recitation on Cell Viability, Cell Migration, and BCL2L12 Gene Expression of Human Prostate Adenocarcinoma Cell Line in Culture

Abstract

Introduction ne of the most frequent nondermatologic malignancies is prostate cancer (1). Different therapeutic methods, such as new treatment options, early diagnosis, and routine screening, have positive and important effects on the survival rate of prostate cancer patients (2). Based on the statistics, in 2012, about one million men were diagnosed with prostate cancer worldwide, 70% of whom were in developed countries. The incidence of prostate cancer in Iran is about 10 per 100,000 individuals (3). It is estimated that about 43% of male cancer survivors in the United States are survivors of prostate cancer, and the rate of 5-year survival across different stages is 99.7% (4). When sound travels through a medium, it can cause turbulence in it. Sound is defined as the compression of a waveform at a specific frequency that passes through air or materials (5). A number of studies have divided sound into three groups: 1) infrasound (below 20 Hz); 2) audible sound (20-20,000 Hz), and 3) ultrasound (above 20 kHz) (6). In the field of medicine, the use of ultrasound is well-known in the diagnosis and treatment of medical problems. Sound can also create mechanical stress and directly affect cells. The disturbance created by sound via the mechanism of particle interaction is probably the cause of such an effect (7).

Sonomechanobiology: Vibrational stimulation of cells and its therapeutic implications

“…Most of the work on acoustic cell stimuli in the infrasound and audible ranges has primarily been limited to cell proliferation, 134–138 cell migration, 138,139 and even apoptosis. 85 Neuronal degeneration has also been reported in astrocytes, neurons, and cardiomyocytes exposed to 16 Hz infrasound, 85,140 whereas upregulation in neuronal differentiation was observed with 1 kHz mechanostimulated bone marrow-derived stem cells (BMD-SCs), 141 although we note that the latter appeared to be dependent on the inclusion of specific biochemical additives, such as dexamethasone, ascorbate, -glycerophosphate, bone morphogenetic protein (BMP), 3-isobutyl-1-methylxanthine, insulin, transferrin, valproic acid, forskolin, neural supplement and human transforming growth factor 1, among others.…”

Music for Cells? A Systematic Review of Studies Investigating the Effects of Audible Sound Played Through Speaker-Based Systems on Cell Cultures

“…In Mehrafsar and Mokhtari (2018), four speakers were placed around the cell culture plate. A voice recording ( Surah Al-Fatina, voice by Sheikh Abdul Basit ) was played at 90 dB SPL for 2 h to the human cancer cell line (PC-3; Human Prostate Adenocarcinoma Cells).…”

Music for cells? A systematic review of studies investigating the effects of audible sound played through speaker-based systems to cell cultures

“…In Mehrafsar et al (35), four speakers were placed around the cell culture plate. A recording of Quran recitation ( Surah Al-Fatina, voice by Sheikh Abdul Basit ) was played at 90 dB SPL for 2 hours to the human cancer cell line (PC-3; Human Prostate Adenocarcinoma Cells).…”

“…For the complex sound stimulation studies, there are too little reports in the literature, but the results are intriguing. The tested music and human voice varied widely: Western classical music such as Mozart, Beethoven, and Ligeti (32), Hindustani classical music such as Ahir Bhairav, Piloo, and Raag Malhar (33,34), an African and Latin American percussive music and a voice of an actor (18), a contemporary composition such as Reminiscenza and Pioggia (7), and Quran recitation such as Surah Al-Fatina (35). The most present frequencies of the music and voices tested stayed between 40 and 840 Hz.…”