Effect of extracts from pine needle against oxidative DNA damage and apoptosis induced by hydroxyl radical via antioxidant activity

DNA protection activity of a hydroethanol extract and six polyphenol monomers fromMorus alba L. (mulberry) twig

“…The results showed that UV irradiation did not induce obvious damage to OcDNA when polyphenols were present compared with solvent controls, but ScDNA was clearly damaged to some degree. When the concentration was lower than 0.500 mg/ mL, breaking of the superhelical structure of ScDNA was apparent, resulting in the appearance of LnDNA and an increase in OcDNA, consistent with the research of Jeong et al, [43] who studied the effects of extracts from pine needles against oxidative DNA damage by hydroxyl radicals. Meanwhile, at the optimal concentration of polyphenol monomers, the amount of OcDNA was lower than that in the solvent treatment, but greater than that in the solvent control.…”

Unexplained Perioperative Hypotension in a Patient Treated with Pine Needle Extract

“…One of the PNE components, proanthocyanidins are pharmacologically essential, which have shown anti-hypertensive effects as well as anti-oxidative effects by repairing oxidative DNA damage and apoptosis due to hydroxyl radicals [3]. A previous study reported that the ingestion of PNE by late-gestation beef cows increased premature delivery rates [7,8], perhaps due to progressively decreased uterine arterial blood flow (>50%) caused by the direct effects of arterial smooth muscle cells or by reduced secretion of estrogen due to low uterine blood flow.…”

“…Different parts of pine trees (Pinus densiflora) are consumed as foods or dietary supplements in East Asia [1,2]. Pine needle extracts (PNE) are especially known as potential anti-hypertensive [2], anti-oxidant [3,4], anti-inflammatory [5], and anti-lipidemic agents [6]. The causes of perioperative hypotension, such as hypovolemia, myocardial depression, anesthetic overdoses, immunologic alteration, endocrine disease, allergic reaction to some antibiotics or other drugs, are very complex.…”

Некоторые Химические Компоненты Сосны

“…Они показали широкий спектр биоло-гического и фармакологического действия, такие как противовоспалительное, антибактериальное, противовирусное, антидепрессантное, а также спо-собствуют уменьшению триглицеридов в организ-ме. Хвоя сосны обладает противогипертензивным эффектом, а также защитными свойствами в отно-шении окислительных повреждений ДНК и апоп-тозоиндуцирующих гидроксильных радикалов [3]. Сосновая кора имеет хорошее защитное свойство от коллагена при коллагенозах [4].…”