Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription

O’Leary, Karen A.; Pascual-Tereasa, Sonia De; Needs, Paul W.; Bao, Yongping; O’Brien, Nora M.; Williamson, Gary

doi:10.1016/j.mrfmmm.2004.01.015

Cited by 291 publications

(181 citation statements)

References 37 publications

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“…A previous study from our group showed that flavonoids suppressed COX-2 mRNA in human colon adenocarcinoma Caco-2 cells (18). Here, SFN at 5, 10 and 20 μM decreased COX-2 mRNA expression by 28, 69 and 87%, respectively after10-h treatment and by 18, 53 and 85%, respectively, after 24-h treatment.…”

Section: Resultssupporting

confidence: 50%

p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells

Shan

Wang

et al. 2010

Oncol Rep

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Abstract. Sulforaphane, a well-characterised dietary isothiocyanate, has been demonstrated to be a potent anticarcinogenic agent in numerous cancer models, including in bladder cancer cells. In the present study, sulforaphane upregulated the expression of two Nrf2-dependent enzymes, glutathione transferase (GSTA1-1) and thioredoxin reductase (TR-1), and down-regulated cyclooxygenase 2 (COX-2) in human bladder cancer T24 cells. This action of sulforaphane was associated with the p38 MAPK activity. When a specific p38 MAPK inhibitor, SB202190, was used, both sulforaphaneinduced up-regulation of GSTA1-1 and TR-1 and downregulation of COX-2 were eliminated; in contrast, an activator of p38 MAPK, anisomycin, enhanced the effect of sulforaphane on modulation of GST, TR-1 and COX-2 expression. Moreover, it was established that anisomycin increased nuclear translocation of Nrf2, whereas SB202190 abrogated sulforaphane-induced Nrf2 translocation into the nucleus. In summary, these data suggest that p38 MAPK activation can regulate Nrf2-antioxidant response element (ARE)-driven enzymes and COX-2 expression, thereby facilitating the role of sulforaphane in cancer prevention. This study strongly supports the contention that p38 MAPK is a pivotal and efficient target of sulforaphane in the chemoprevention of bladder cancer.

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Section: Resultssupporting

confidence: 50%

p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells

Shan

Wang

et al. 2010

Oncol Rep

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“…Some studies have found that Vitamin E and its metabolites have an anti-inflammatory and anti-COX2 property [43]. In our recent study we evaluated and verified the effectiveness of Vitamin E in the treatment of PD [17].…”

Section: Discussionmentioning

confidence: 80%

Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Patients with Peyronie's Disease. Results of a Controlled Study

Paulis¹,

Farina²,

Cavallini³

et al. 2014

Andrology(Los Angel)

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Objective: The study was made mainly to investigate the possible benefits of multimodal treatment using Pentoxifylline (PTX) with other antioxidants, in patients with PD enrolled for a conservative medical management. Methods: We carried out a controlled study on 240 patients diagnosed with Peyronie's Disease (PD). We have divided two treatment groups, which differ from each other only for the association with PTX-penile injection. Two groups (A and B) were totally composed by 160 PD patients (80 patients for each group): Group A=PTX injection (penile and peri-lesional) 100 mg, every two weeks for six months + PTX 400 mg /oral/ twice daily + propolis 600 mg / oral / daily + blueberries 160 mg /oral/ daily + Vitamin E 600 mg / oral / daily + topical Diclofenac sodium 4% gel / twice a day, for a period of 6 months. Group B=the same therapy of group A but without PTX penile injection. Patients who refused treatment, for various reasons, were included in the control group=Group C (80 patients). Results: In groups A and B after 6 months of treatment a reduction of penile plaque volume of 50.3% and 25.9% respectively was observed, while in group C a mean increase in plaque volume of 131% was observed. Furthermore, in groups A and B, the mean curvature decrease was -11.07° and -4.4° respectively, while in group C a mean increase of curvature =+14.09° was observed. Conclusion: Our results showed that multimodal treatment with PTX associated with antioxidants and topical Diclofenac is significantly effective in treating PD. Treatment outcomes obtained in the treatment-group A are statistically more significant than those achieved in group B. Pentoxifylline is more effective when the treatment program includes both routes of administration: oral + perilesional injection.

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“…The phytochemical study of the extract revealed the presence of saponins, alkaloids, cardiotonic-heterosids, steroids and terpenoïds as well as tannins (Bokia, 2016). The presence of the flavonoïds could explain the antiinflammatory effect (Bagli et al, 2004;O'Leary et al, 2004), flavonoïds and alkaloïds would explain the analgesic effect (Borgi et al, 2007;Sudo et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and analgesic effects of leaves of Chromolaena odorata L. (King and Robinson)

Itou¹,

Ossibi²,

Epa³

et al. 2017

Afr. J. Pharm. Pharmacol.

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This study was to evaluate anti-inflammatory and analgesic effects of the aqueous extract of leaves of Chromolaena odorata (Asteraceae) collected in Brazzaville-Congo. Acute inflammation was induced by using the carrageenan and formaldehyde models, and chronic inflammation by the cotton pellet induced granuloma model. Analgesic effect was evaluated by using the acetic acid-induced writhing, the pressure induced by the analgesymeter as well as the pain induced by formaldehyde. The results obtained show that aqueous extract (400 and 800 mg/kg) inhibits the edema induced by the carrageenan and formaldehyde. Moreover, this extract at the doses used (400 and 800 mg/kg) significantly inhibits granuloma fabric induced by cotton pellet. In addition, aqueous extract (400 and 800 mg/kg) inhibits significantly the pain induced by the three methods used. In conclusion, aqueous extract of C. odorata has anti-inflammatory and analgesic effects. These observations justify the traditional use of this plant in the treatment of inflammatory pathologies and the pain.

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Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription

Cited by 291 publications

References 37 publications

p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells

p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells

Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Patients with Peyronie's Disease. Results of a Controlled Study

Anti-inflammatory and analgesic effects of leaves of Chromolaena odorata L. (King and Robinson)

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