Effect of Fracture on Bone Turnover Markers: A Longitudinal Study Comparing Marker Levels Before and After Injury in 113 Elderly Women

Ivaska, Kaisa K.; Gerdhem, Paul; Åkesson, Kristina; Garnero, Patrick; Obrant, Karl

doi:10.1359/jbmr.070505

Cited by 154 publications

(107 citation statements)

References 42 publications

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“…In the primary analysis, we additionally excluded all women (n ¼ 65) who had suffered a fracture within 24 months prior to the baseline visit because bone turnover is elevated for up to a year in the aftermath of a fracture. (36) The promoter polymorphism (rs1800247) was found to be significantly associated with levels of S-TotalOC ( p ¼ .01). Even after controlling for BMI and TB BMD, the association remained significant ( p ¼ 0.012; Table 3).…”

Section: Resultsmentioning

confidence: 98%

Osteocalcin gene polymorphisms influence concentration of serum osteocalcin and enhance fracture identification

McGuigan

Kumar

Ivaska

et al. 2010

Journal of Bone and Mineral Research

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Osteoporosis is a major health problem affecting more than 75 million people throughout Europe, the United States, and Japan. Epidemiologic studies have determined that both genetic and environmental factors contribute to the pathogenesis of osteoporosis. We have investigated the association between polymorphisms at the osteocalcin locus and variables linked to bone health. Osteocalcin provides a link between bone and energy metabolism, hence its potential importance as an osteoporosis candidate gene. In this study, we included a total of 996 women (all aged 75 years) from the Osteoporosis Prospective Risk Assessment (OPRA) cohort. We sequenced the osteocalcin gene along with flanking regions to search for novel coding polymorphisms. We also analyzed four polymorphisms selected from within and flanking regions of the osteocalcin gene to study their association with serum total osteocalcin levels (STotalOC), total-body (TB) bone mineral density (BMD), fracture, TB fat mass, and body mass index (BMI). The promoter polymorphism rs1800247 was significantly associated with S-TotalOC ( p ¼ .012) after controlling for BMI and TB BMD. The polymorphism rs1543297 was significantly associated with prospectively occurring fractures ( p ¼ .008). In a model taking into account rs1543297 and rs1800247, along with TB BMD, BMI, smoking, and S-TotalOC, the polymorphisms together were able to identify an additional 6% of women who sustained a fracture ( p ¼ .02). We found no association between the polymorphisms and TB BMD, BMI, or TB fat mass. In conclusion, polymorphisms in and around the osteocalcin locus are significantly associated with S-TotalOC and fracture. Genotyping at the osteocalcin locus could add valuable information in the identification of women at risk of osteoporosis. ß

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Section: Resultsmentioning

confidence: 98%

Osteocalcin gene polymorphisms influence concentration of serum osteocalcin and enhance fracture identification

McGuigan

Kumar

Ivaska

et al. 2010

Journal of Bone and Mineral Research

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“…In addition, the inflammatory process, which is more with the increasing number of bones fractured, will result in an increase in blood flow to the fractured sites and more calcium resorption during the repair process. The study by Ivaska et al 8 showed that, during fracture repair, most bone turnover markers were significantly elevated with an early increase in the resorption markers and a somewhat later rise in the formation markers.…”

Section: Discussionmentioning

confidence: 99%

Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients

et al. 2015

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Hypercalcemia and hypercalciuria secondary to immobilization can be occasionally severe, producing an array of symptoms. This study looked at possible determinants of hypercalcemia and hypercalciuria in immobilized trauma patients. This is a prospective observational study carried out over a period of 7 months. Fifty-five immobilized trauma patients were evaluated weekly for 4 weeks for symptoms of hypercalcemia, total serum calcium and 24-h urinary calcium. The number of limbs immobilized had a significant relationship with hypercalcemia at the end of week 1 (Po0.001) and week 4 (P ¼ 0.008) and with hypercalciuria at the end of week 1 only (Po0.001). The number of bones fractured also had a significant relationship with hypercalcemia at the end of week 1 (P ¼ 0.005) and week 4 (P ¼ 0.019), as well as with hypercalciuria at the end of week 1 (Po0.001) and week 2 (P ¼ 0.036). Weight loss was significantly associated with hypercalcemia at the end of week 4 (P ¼ 0.014) and with hypercalciuria at the end of week 3 (Po0.001) and week 4 (Po0.001), whereas polyuria and polydipsia had a significant association with hypercalciuria at the end of week 2 (Po0.001) and week 3 (P ¼ 0.030). The number of limbs immobilized and bones fractured showed an early significant relationship with the development of hypercalcemia and hypercalciuria. Weight loss showed late association with hypercalcemia and hypercalciuria, whereas polyuria and polydipsia showed early association with hypercalciuria.

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“…A recently sustained fracture alters bone turnover. Bone formation and resorption markers increase as early as a minimum of 4 months after the fracture, reflecting bone healing (31).…”

Section: Bone-specific Alkaline Phosphatasementioning

confidence: 99%

Bone turnover assessment: a good surrogate marker?

Dreyer

Vieira

2010

Arq Bras Endocrinol Metab

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SummaryTo asses fracture risk, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the most commonly used tool. The search for clinical risk factors is also advised and can provide a 10-year fracture probability (FRAX model). Another important determinant of bone strength is bone remodeling. High bone remodeling rates have been associated with a higher fracture risk and bone turnover markers (BTM) may offer dynamic information about skeletal status independent of BMD. The efficacy of antiresorptive agents in fracture prevention goes beyond what can be predicted by BMD especially in the beginning of the treatment. Inhibition of bone remodeling itself is certainly an important mechanism by which antiresorptive agents can rapidly reduce fracture risk. Thus, it seems quite logical to use BTM in patients with bone disease. It can also become a valuable surrogate marker in fracture prediction. However, BTM's pre-analytical and analytical variability should always be considered. Arq Bras Endocrinol Metab. 2010;54(2):99-105 Keywords Bone turnover; biochemical markers; osteoporosis; fracture SumárioO método mais utilizado para avaliação do risco de fraturas é a densitometria óssea pela téc-nica de DXA (absorciometria por raios-X duo-energética). A pesquisa de condições clínicas de risco também é recomendada e fornece uma estimativa da probabilidade de fratura em 10 anos (modelo FRAX). Outro fator importante é o grau de remodelação óssea. Um aumento da taxa de remodelação tem sido associado a um maior risco de fraturas e aumento dos marcadores ósseos. A medida desses marcadores fornece informação adicional independente da densitometria. A eficiência das medicações antirreabsortivas na prevenção de fraturas não é explicada apenas pelo aumento da densidade óssea. A menor remodelação óssea é um mecanismo que pode explicar a redução da taxa de fraturas principalmente no início do tratamento. A utilização desses marcadores nas doenças ósseas e na predição de fraturas torna-se lógica. No entanto, para interpretá-los corretamente sua variação pré-analítica e analítica deve ser considerada. Arq Bras Endocrinol Metab. 2010;54(2):99-105 Descritores Remodelação óssea; marcadores ósseos; osteoporose; fratura

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Effect of Fracture on Bone Turnover Markers: A Longitudinal Study Comparing Marker Levels Before and After Injury in 113 Elderly Women

Cited by 154 publications

References 42 publications

Osteocalcin gene polymorphisms influence concentration of serum osteocalcin and enhance fracture identification

Osteocalcin gene polymorphisms influence concentration of serum osteocalcin and enhance fracture identification

Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients

Bone turnover assessment: a good surrogate marker?

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